New Method for Preparing Small-Caliber Artificial Blood Vessel with Controllable Microstructure on the Inner Wall Based on Additive Material Composite Molding

The diameter of most blood vessels in cardiovascular and peripheral vascular system is less than 6 mm. Because the inner diameter of such vessels is small, a built-in stent often leads to thrombosis and other problems. It is an important goal to replace it directly with artificial vessels. This pape...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Junchao Hu, Zhian Jian, Chunxiang Lu, Na Liu, Tao Yue, Weixia Lan, Yuanyuan Liu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	small caliber blood vessel composite molding micro-nano structure tissue repair 3D printing Mechanical engineering and machinery TJ1-1570
Acceso en línea:	https://doaj.org/article/7c4fa12a41ae43aa9782726d15791d69
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7c4fa12a41ae43aa9782726d15791d69
record_format	dspace
spelling	oai:doaj.org-article:7c4fa12a41ae43aa9782726d15791d692021-11-25T18:23:02ZNew Method for Preparing Small-Caliber Artificial Blood Vessel with Controllable Microstructure on the Inner Wall Based on Additive Material Composite Molding10.3390/mi121113122072-666Xhttps://doaj.org/article/7c4fa12a41ae43aa9782726d15791d692021-10-01T00:00:00Zhttps://www.mdpi.com/2072-666X/12/11/1312https://doaj.org/toc/2072-666XThe diameter of most blood vessels in cardiovascular and peripheral vascular system is less than 6 mm. Because the inner diameter of such vessels is small, a built-in stent often leads to thrombosis and other problems. It is an important goal to replace it directly with artificial vessels. This paper creatively proposed a preparation method of a small-diameter artificial vascular graft which can form a controllable microstructure on the inner wall and realize a multi-material composite. On the one hand, the inner wall of blood vessels containing direct writing structure is constructed by electrostatic direct writing and micro-imprinting technology to regulate cell behavior and promote endothelialization; on the other hand, the outer wall of blood vessels was prepared by electrospinning PCL to ensure the stability of mechanical properties of composite grafts. By optimizing the key parameters of the graft, a small-diameter artificial blood vessel with controllable microstructure on the inner wall is finally prepared. The corresponding performance characterization experimental results show that it has advantages in structure, mechanical properties, and promoting endothelialization.Junchao HuZhian JianChunxiang LuNa LiuTao YueWeixia LanYuanyuan LiuMDPI AGarticlesmall caliber blood vesselcomposite moldingmicro-nano structuretissue repair3D printingMechanical engineering and machineryTJ1-1570ENMicromachines, Vol 12, Iss 1312, p 1312 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	small caliber blood vessel composite molding micro-nano structure tissue repair 3D printing Mechanical engineering and machinery TJ1-1570
spellingShingle	small caliber blood vessel composite molding micro-nano structure tissue repair 3D printing Mechanical engineering and machinery TJ1-1570 Junchao Hu Zhian Jian Chunxiang Lu Na Liu Tao Yue Weixia Lan Yuanyuan Liu New Method for Preparing Small-Caliber Artificial Blood Vessel with Controllable Microstructure on the Inner Wall Based on Additive Material Composite Molding
description	The diameter of most blood vessels in cardiovascular and peripheral vascular system is less than 6 mm. Because the inner diameter of such vessels is small, a built-in stent often leads to thrombosis and other problems. It is an important goal to replace it directly with artificial vessels. This paper creatively proposed a preparation method of a small-diameter artificial vascular graft which can form a controllable microstructure on the inner wall and realize a multi-material composite. On the one hand, the inner wall of blood vessels containing direct writing structure is constructed by electrostatic direct writing and micro-imprinting technology to regulate cell behavior and promote endothelialization; on the other hand, the outer wall of blood vessels was prepared by electrospinning PCL to ensure the stability of mechanical properties of composite grafts. By optimizing the key parameters of the graft, a small-diameter artificial blood vessel with controllable microstructure on the inner wall is finally prepared. The corresponding performance characterization experimental results show that it has advantages in structure, mechanical properties, and promoting endothelialization.
format	article
author	Junchao Hu Zhian Jian Chunxiang Lu Na Liu Tao Yue Weixia Lan Yuanyuan Liu
author_facet	Junchao Hu Zhian Jian Chunxiang Lu Na Liu Tao Yue Weixia Lan Yuanyuan Liu
author_sort	Junchao Hu
title	New Method for Preparing Small-Caliber Artificial Blood Vessel with Controllable Microstructure on the Inner Wall Based on Additive Material Composite Molding
title_short	New Method for Preparing Small-Caliber Artificial Blood Vessel with Controllable Microstructure on the Inner Wall Based on Additive Material Composite Molding
title_full	New Method for Preparing Small-Caliber Artificial Blood Vessel with Controllable Microstructure on the Inner Wall Based on Additive Material Composite Molding
title_fullStr	New Method for Preparing Small-Caliber Artificial Blood Vessel with Controllable Microstructure on the Inner Wall Based on Additive Material Composite Molding
title_full_unstemmed	New Method for Preparing Small-Caliber Artificial Blood Vessel with Controllable Microstructure on the Inner Wall Based on Additive Material Composite Molding
title_sort	new method for preparing small-caliber artificial blood vessel with controllable microstructure on the inner wall based on additive material composite molding
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7c4fa12a41ae43aa9782726d15791d69
work_keys_str_mv	AT junchaohu newmethodforpreparingsmallcaliberartificialbloodvesselwithcontrollablemicrostructureontheinnerwallbasedonadditivematerialcompositemolding AT zhianjian newmethodforpreparingsmallcaliberartificialbloodvesselwithcontrollablemicrostructureontheinnerwallbasedonadditivematerialcompositemolding AT chunxianglu newmethodforpreparingsmallcaliberartificialbloodvesselwithcontrollablemicrostructureontheinnerwallbasedonadditivematerialcompositemolding AT naliu newmethodforpreparingsmallcaliberartificialbloodvesselwithcontrollablemicrostructureontheinnerwallbasedonadditivematerialcompositemolding AT taoyue newmethodforpreparingsmallcaliberartificialbloodvesselwithcontrollablemicrostructureontheinnerwallbasedonadditivematerialcompositemolding AT weixialan newmethodforpreparingsmallcaliberartificialbloodvesselwithcontrollablemicrostructureontheinnerwallbasedonadditivematerialcompositemolding AT yuanyuanliu newmethodforpreparingsmallcaliberartificialbloodvesselwithcontrollablemicrostructureontheinnerwallbasedonadditivematerialcompositemolding
_version_	1718411267678404608

New Method for Preparing Small-Caliber Artificial Blood Vessel with Controllable Microstructure on the Inner Wall Based on Additive Material Composite Molding

Ejemplares similares