The use of GnRH analogs in preserving ovarian function during chemotherapy

Abstract Background The literature has always been controversial on the use of gonadotropin-releasing hormone agonists in preserving fertility in women of childbearing age after chemotherapy; thereby, in this article, we will be discussing its use in preserving fertility. Main body of abstract When...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Omar M. Odeh, Johnny Awwad, Dalia Khalife, Suleiman Ghunaim
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	GnRH agonists Fertility Chemotherapy Medicine (General) R5-920 Reproduction QH471-489
Acceso en línea:	https://doaj.org/article/7c4fe4d711f4490d89062e414857118b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7c4fe4d711f4490d89062e414857118b
record_format	dspace
spelling	oai:doaj.org-article:7c4fe4d711f4490d89062e414857118b2021-11-07T12:18:14ZThe use of GnRH analogs in preserving ovarian function during chemotherapy10.1186/s43043-021-00088-x2090-3251https://doaj.org/article/7c4fe4d711f4490d89062e414857118b2021-11-01T00:00:00Zhttps://doi.org/10.1186/s43043-021-00088-xhttps://doaj.org/toc/2090-3251Abstract Background The literature has always been controversial on the use of gonadotropin-releasing hormone agonists in preserving fertility in women of childbearing age after chemotherapy; thereby, in this article, we will be discussing its use in preserving fertility. Main body of abstract When it comes to preserving fertility, it is crucial to consider all available options in this topic due to its very sensitive nature, thereby we have found that while a lot of trials favor the use of gonadotropin-releasing hormone agonists, the lack of proper follow-up and long-term trials renders its use highly debatable, and since the longest follow-up trial showed non-significant results, it also opens the floor for debate on whether this short-term benefit is worth adding another drug to the regimen or not. Short conclusion As described in this review, while the use of gonadotropin-releasing hormone agonists is beneficial in a lot of studies, the lack of long-term reports still makes its use debatable, thereby more trials should be done.Omar M. OdehJohnny AwwadDalia KhalifeSuleiman GhunaimSpringerOpenarticleGnRH agonistsFertilityChemotherapyMedicine (General)R5-920ReproductionQH471-489ENMiddle East Fertility Society Journal, Vol 26, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	GnRH agonists Fertility Chemotherapy Medicine (General) R5-920 Reproduction QH471-489
spellingShingle	GnRH agonists Fertility Chemotherapy Medicine (General) R5-920 Reproduction QH471-489 Omar M. Odeh Johnny Awwad Dalia Khalife Suleiman Ghunaim The use of GnRH analogs in preserving ovarian function during chemotherapy
description	Abstract Background The literature has always been controversial on the use of gonadotropin-releasing hormone agonists in preserving fertility in women of childbearing age after chemotherapy; thereby, in this article, we will be discussing its use in preserving fertility. Main body of abstract When it comes to preserving fertility, it is crucial to consider all available options in this topic due to its very sensitive nature, thereby we have found that while a lot of trials favor the use of gonadotropin-releasing hormone agonists, the lack of proper follow-up and long-term trials renders its use highly debatable, and since the longest follow-up trial showed non-significant results, it also opens the floor for debate on whether this short-term benefit is worth adding another drug to the regimen or not. Short conclusion As described in this review, while the use of gonadotropin-releasing hormone agonists is beneficial in a lot of studies, the lack of long-term reports still makes its use debatable, thereby more trials should be done.
format	article
author	Omar M. Odeh Johnny Awwad Dalia Khalife Suleiman Ghunaim
author_facet	Omar M. Odeh Johnny Awwad Dalia Khalife Suleiman Ghunaim
author_sort	Omar M. Odeh
title	The use of GnRH analogs in preserving ovarian function during chemotherapy
title_short	The use of GnRH analogs in preserving ovarian function during chemotherapy
title_full	The use of GnRH analogs in preserving ovarian function during chemotherapy
title_fullStr	The use of GnRH analogs in preserving ovarian function during chemotherapy
title_full_unstemmed	The use of GnRH analogs in preserving ovarian function during chemotherapy
title_sort	use of gnrh analogs in preserving ovarian function during chemotherapy
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/7c4fe4d711f4490d89062e414857118b
work_keys_str_mv	AT omarmodeh theuseofgnrhanalogsinpreservingovarianfunctionduringchemotherapy AT johnnyawwad theuseofgnrhanalogsinpreservingovarianfunctionduringchemotherapy AT daliakhalife theuseofgnrhanalogsinpreservingovarianfunctionduringchemotherapy AT suleimanghunaim theuseofgnrhanalogsinpreservingovarianfunctionduringchemotherapy AT omarmodeh useofgnrhanalogsinpreservingovarianfunctionduringchemotherapy AT johnnyawwad useofgnrhanalogsinpreservingovarianfunctionduringchemotherapy AT daliakhalife useofgnrhanalogsinpreservingovarianfunctionduringchemotherapy AT suleimanghunaim useofgnrhanalogsinpreservingovarianfunctionduringchemotherapy
_version_	1718443497617358848

The use of GnRH analogs in preserving ovarian function during chemotherapy

Ejemplares similares