Validation and verification of the OPI 2.0 System

Richard Abelson1,2, Keith J Lane3, John Rodriguez3, Patrick Johnston3, Endri Angjeli3, George Ousler3, Douglas Montgomery11School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, Tempe, AZ, 2Statistics and Data Corporation, Tempe, AZ, 3Ora, Inc, Andover, MA, USA...

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Autores principales:	Abelson R, Lane KJ, Rodriguez J, Johnston P, Angjeli E, Ousler G, Montgomery D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/7c507a53b602492982bb9452c13b9e8a
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spelling	oai:doaj.org-article:7c507a53b602492982bb9452c13b9e8a2021-12-02T01:55:46ZValidation and verification of the OPI 2.0 System1177-54671177-5483https://doaj.org/article/7c507a53b602492982bb9452c13b9e8a2012-04-01T00:00:00Zhttp://www.dovepress.com/validation-and-verification-of-the-opi-20-system-a9768https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Richard Abelson1,2, Keith J Lane3, John Rodriguez3, Patrick Johnston3, Endri Angjeli3, George Ousler3, Douglas Montgomery11School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, Tempe, AZ, 2Statistics and Data Corporation, Tempe, AZ, 3Ora, Inc, Andover, MA, USAPurpose: The Ocular Protection Index (OPI) 2.0 System was developed to evaluate ocular surface protection under a natural blink pattern and normal visual conditions. The OPI 2.0 System implements fully automated software algorithms which provide a real-time measurement of corneal exposure (breakup area) for each interblink interval during a 1-minute video. Utilizing this method, the mean breakup area (MBA) and OPI 2.0 (MBA/interblink interval) were calculated and analyzed. The purpose of this study was to verify and validate the OPI 2.0 System for its ability to distinguish between dry eye and normal subjects, and to accurately identify breakup area.Methods: In order to verify and validate the OPI 2.0 System, a series of artificial images and a series of still image frames captured during an actual clinical session using fluorescein staining videography were analyzed. Finally, a clinical validation process was completed to determine the effectiveness and clinical relevance of the OPI 2.0 System to differentiate between dry eye and normal subjects.Results: Software analysis verification conducted in a set of artificially constructed images and in actual videos both saw minimal error rates. MBA and OPI 2.0 calculations were able to distinguish between the qualifying eyes of dry eye and normal subjects in a statistically significant fashion (P &lt; 0.001 for both outcomes). As expected, dry eye subjects had a higher MBA and OPI 2.0 than normal subjects (0.232, dry eye; 0.040, normal and 0.039, dry eye; 0.006, normal, respectively). Results for the worst eyes and all qualifying analyses based on staining, forced-stare tear film breakup time, and MBA were numerically similar.Conclusion: The OPI 2.0 System accurately identifies the degree of breakup area on the cornea and represents an efficient, clinically relevant measurement of the pathophysiology of the ocular surface.Keywords: tear film breakup time, interblink interval, natural blink conditions, Ocular Protection IndexAbelson RLane KJRodriguez JJohnston PAngjeli EOusler GMontgomery DDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 613-622 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Abelson R Lane KJ Rodriguez J Johnston P Angjeli E Ousler G Montgomery D Validation and verification of the OPI 2.0 System
description	Richard Abelson1,2, Keith J Lane3, John Rodriguez3, Patrick Johnston3, Endri Angjeli3, George Ousler3, Douglas Montgomery11School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, Tempe, AZ, 2Statistics and Data Corporation, Tempe, AZ, 3Ora, Inc, Andover, MA, USAPurpose: The Ocular Protection Index (OPI) 2.0 System was developed to evaluate ocular surface protection under a natural blink pattern and normal visual conditions. The OPI 2.0 System implements fully automated software algorithms which provide a real-time measurement of corneal exposure (breakup area) for each interblink interval during a 1-minute video. Utilizing this method, the mean breakup area (MBA) and OPI 2.0 (MBA/interblink interval) were calculated and analyzed. The purpose of this study was to verify and validate the OPI 2.0 System for its ability to distinguish between dry eye and normal subjects, and to accurately identify breakup area.Methods: In order to verify and validate the OPI 2.0 System, a series of artificial images and a series of still image frames captured during an actual clinical session using fluorescein staining videography were analyzed. Finally, a clinical validation process was completed to determine the effectiveness and clinical relevance of the OPI 2.0 System to differentiate between dry eye and normal subjects.Results: Software analysis verification conducted in a set of artificially constructed images and in actual videos both saw minimal error rates. MBA and OPI 2.0 calculations were able to distinguish between the qualifying eyes of dry eye and normal subjects in a statistically significant fashion (P &lt; 0.001 for both outcomes). As expected, dry eye subjects had a higher MBA and OPI 2.0 than normal subjects (0.232, dry eye; 0.040, normal and 0.039, dry eye; 0.006, normal, respectively). Results for the worst eyes and all qualifying analyses based on staining, forced-stare tear film breakup time, and MBA were numerically similar.Conclusion: The OPI 2.0 System accurately identifies the degree of breakup area on the cornea and represents an efficient, clinically relevant measurement of the pathophysiology of the ocular surface.Keywords: tear film breakup time, interblink interval, natural blink conditions, Ocular Protection Index
format	article
author	Abelson R Lane KJ Rodriguez J Johnston P Angjeli E Ousler G Montgomery D
author_facet	Abelson R Lane KJ Rodriguez J Johnston P Angjeli E Ousler G Montgomery D
author_sort	Abelson R
title	Validation and verification of the OPI 2.0 System
title_short	Validation and verification of the OPI 2.0 System
title_full	Validation and verification of the OPI 2.0 System
title_fullStr	Validation and verification of the OPI 2.0 System
title_full_unstemmed	Validation and verification of the OPI 2.0 System
title_sort	validation and verification of the opi 2.0 system
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/7c507a53b602492982bb9452c13b9e8a
work_keys_str_mv	AT abelsonr validationandverificationoftheopi20system AT lanekj validationandverificationoftheopi20system AT rodriguezj validationandverificationoftheopi20system AT johnstonp validationandverificationoftheopi20system AT angjelie validationandverificationoftheopi20system AT ouslerg validationandverificationoftheopi20system AT montgomeryd validationandverificationoftheopi20system
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Validation and verification of the OPI 2.0 System

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