Insights into the binding of Phenyltiocarbamide (PTC) agonist to its target human TAS2R38 bitter receptor.
Humans' bitter taste perception is mediated by the hTAS2R subfamily of the G protein-coupled membrane receptors (GPCRs). Structural information on these receptors is currently limited. Here we identify residues involved in the binding of phenylthiocarbamide (PTC) and in receptor activation in o...
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Autores principales: | Xevi Biarnés, Alessandro Marchiori, Alejandro Giorgetti, Carmela Lanzara, Paolo Gasparini, Paolo Carloni, Stephan Born, Anne Brockhoff, Maik Behrens, Wolfgang Meyerhof |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2010
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Materias: | |
Acceso en línea: | https://doaj.org/article/7c539980badb433aa3fb2d36290a2b4b |
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