The H/ACA complex disrupts triplex in hTR precursor to permit processing by RRP6 and PARN

Telomerase RNA (hTR) is transcribed as a 3′-extended precursor. Here the authors examine the processing of hTR precursors of various lengths and show that processing occurs in distinct steps involving different nucleases PARN and RRP6.

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Autores principales: Chi-Kang Tseng, Hui-Fang Wang, Morgan R. Schroeder, Peter Baumann
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/7c53ca334961462392633af0c6271d1f
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Sumario:Telomerase RNA (hTR) is transcribed as a 3′-extended precursor. Here the authors examine the processing of hTR precursors of various lengths and show that processing occurs in distinct steps involving different nucleases PARN and RRP6.