Metabonomics Approach to Assessing the Modulatory Effects of Kisspeptin-10 on Liver Injury Induced by Heat Stress in Rats

Abstract The protective effects of Kisspeptin on heat-induced oxidative stress in rats were investigated by using a combination of biochemical parameters and metabonomics. Metabonomic analyses were performed using gas chromatography/mass spectrometry in conjunction with multivariate and univariate s...

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Autores principales:	Yuanlong Hou, Xiaoyan Wang, Jihui Ping, Zhihai Lei, Yingdong Gao, Zhiyu Ma, Cuicui Jia, Zheng Zhang, Xiang Li, Mengmeng Jin, Xiaoliang Li, Chuan Suo, Ying Zhang, Juan Su
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7c5563ddd0fc49d89c7995b58a605b61
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spelling	oai:doaj.org-article:7c5563ddd0fc49d89c7995b58a605b612021-12-02T11:40:30ZMetabonomics Approach to Assessing the Modulatory Effects of Kisspeptin-10 on Liver Injury Induced by Heat Stress in Rats10.1038/s41598-017-06017-12045-2322https://doaj.org/article/7c5563ddd0fc49d89c7995b58a605b612017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06017-1https://doaj.org/toc/2045-2322Abstract The protective effects of Kisspeptin on heat-induced oxidative stress in rats were investigated by using a combination of biochemical parameters and metabonomics. Metabonomic analyses were performed using gas chromatography/mass spectrometry in conjunction with multivariate and univariate statistical analyses. At the end point of the heat stress experiment, histological observation, ultrastructural analysis and biochemical parameters were measured. Metabonomic analysis of liver tissue revealed that Kisspeptin mainly attenuated the alteration of purine metabolism and fatty acid metabolism pathways. Futhermore, Kisspeptin also increased the levels of GSH, T-AOC as well as SOD activities, and upregulated MDA levels. These results provide important mechanistic insights into the protective effects of Kisspeptin against heat-induced oxidative stress.Yuanlong HouXiaoyan WangJihui PingZhihai LeiYingdong GaoZhiyu MaCuicui JiaZheng ZhangXiang LiMengmeng JinXiaoliang LiChuan SuoYing ZhangJuan SuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuanlong Hou Xiaoyan Wang Jihui Ping Zhihai Lei Yingdong Gao Zhiyu Ma Cuicui Jia Zheng Zhang Xiang Li Mengmeng Jin Xiaoliang Li Chuan Suo Ying Zhang Juan Su Metabonomics Approach to Assessing the Modulatory Effects of Kisspeptin-10 on Liver Injury Induced by Heat Stress in Rats
description	Abstract The protective effects of Kisspeptin on heat-induced oxidative stress in rats were investigated by using a combination of biochemical parameters and metabonomics. Metabonomic analyses were performed using gas chromatography/mass spectrometry in conjunction with multivariate and univariate statistical analyses. At the end point of the heat stress experiment, histological observation, ultrastructural analysis and biochemical parameters were measured. Metabonomic analysis of liver tissue revealed that Kisspeptin mainly attenuated the alteration of purine metabolism and fatty acid metabolism pathways. Futhermore, Kisspeptin also increased the levels of GSH, T-AOC as well as SOD activities, and upregulated MDA levels. These results provide important mechanistic insights into the protective effects of Kisspeptin against heat-induced oxidative stress.
format	article
author	Yuanlong Hou Xiaoyan Wang Jihui Ping Zhihai Lei Yingdong Gao Zhiyu Ma Cuicui Jia Zheng Zhang Xiang Li Mengmeng Jin Xiaoliang Li Chuan Suo Ying Zhang Juan Su
author_facet	Yuanlong Hou Xiaoyan Wang Jihui Ping Zhihai Lei Yingdong Gao Zhiyu Ma Cuicui Jia Zheng Zhang Xiang Li Mengmeng Jin Xiaoliang Li Chuan Suo Ying Zhang Juan Su
author_sort	Yuanlong Hou
title	Metabonomics Approach to Assessing the Modulatory Effects of Kisspeptin-10 on Liver Injury Induced by Heat Stress in Rats
title_short	Metabonomics Approach to Assessing the Modulatory Effects of Kisspeptin-10 on Liver Injury Induced by Heat Stress in Rats
title_full	Metabonomics Approach to Assessing the Modulatory Effects of Kisspeptin-10 on Liver Injury Induced by Heat Stress in Rats
title_fullStr	Metabonomics Approach to Assessing the Modulatory Effects of Kisspeptin-10 on Liver Injury Induced by Heat Stress in Rats
title_full_unstemmed	Metabonomics Approach to Assessing the Modulatory Effects of Kisspeptin-10 on Liver Injury Induced by Heat Stress in Rats
title_sort	metabonomics approach to assessing the modulatory effects of kisspeptin-10 on liver injury induced by heat stress in rats
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7c5563ddd0fc49d89c7995b58a605b61
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Metabonomics Approach to Assessing the Modulatory Effects of Kisspeptin-10 on Liver Injury Induced by Heat Stress in Rats

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