Genomic Perspectives on Aeromonas salmonicida subsp. salmonicida Strain 890054 as a Model System for Pathogenicity Studies and Mitigation of Fish Infections

Aeromonas salmonicida subsp. salmonicida is a Gram-negative bacterium that causes furunculosis, a fish disease claiming substantial economic losses in the aquaculture industry. Major challenges exist in monitoring and controlling fish infections in aquaculture farms. Development of management practi...

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Autores principales:	Jeff Gauthier, Hélène Marquis, Valérie E. Paquet, Steve J. Charette, Roger C. Levesque, Nicolas Derome
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Aeromonas salmonicida host–pathogen models salmonid fish genome Science Q General. Including nature conservation, geographical distribution QH1-199.5
Acceso en línea:	https://doaj.org/article/7c5cf0000bd04b78ad77c93f158400e3
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spelling	oai:doaj.org-article:7c5cf0000bd04b78ad77c93f158400e32021-11-10T06:04:15ZGenomic Perspectives on Aeromonas salmonicida subsp. salmonicida Strain 890054 as a Model System for Pathogenicity Studies and Mitigation of Fish Infections2296-774510.3389/fmars.2021.744052https://doaj.org/article/7c5cf0000bd04b78ad77c93f158400e32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmars.2021.744052/fullhttps://doaj.org/toc/2296-7745Aeromonas salmonicida subsp. salmonicida is a Gram-negative bacterium that causes furunculosis, a fish disease claiming substantial economic losses in the aquaculture industry. Major challenges exist in monitoring and controlling fish infections in aquaculture farms. Development of management practices to improve the sustainability of fish farming with disease prevention necessitates studies using well-defined systems and well-characterized bacterial isolates. Even though several A. salmonicida subsp. salmonicida genomes have been completely assembled and thoroughly annotated, in vivo pathogenicity data are lacking. Here we present A. salmonicida subsp. salmonicida 890054 as a prototype strain for standardized furunculosis challenges with survival data. Computational analysis of sequencing results provided a complete circular genome with annotations of plasmids carrying virulence factors, antimicrobial resistance, and secondary metabolite coding genes. The analysis also revealed the presence of an IncU plasmid distinct from other IncU plasmids previously associated with Aeromonas.Jeff GauthierJeff GauthierJeff GauthierHélène MarquisValérie E. PaquetValérie E. PaquetValérie E. PaquetSteve J. CharetteSteve J. CharetteSteve J. CharetteRoger C. LevesqueRoger C. LevesqueNicolas DeromeNicolas DeromeFrontiers Media S.A.articleAeromonas salmonicidahost–pathogen modelssalmonidfishgenomeScienceQGeneral. Including nature conservation, geographical distributionQH1-199.5ENFrontiers in Marine Science, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Aeromonas salmonicida host–pathogen models salmonid fish genome Science Q General. Including nature conservation, geographical distribution QH1-199.5
spellingShingle	Aeromonas salmonicida host–pathogen models salmonid fish genome Science Q General. Including nature conservation, geographical distribution QH1-199.5 Jeff Gauthier Jeff Gauthier Jeff Gauthier Hélène Marquis Valérie E. Paquet Valérie E. Paquet Valérie E. Paquet Steve J. Charette Steve J. Charette Steve J. Charette Roger C. Levesque Roger C. Levesque Nicolas Derome Nicolas Derome Genomic Perspectives on Aeromonas salmonicida subsp. salmonicida Strain 890054 as a Model System for Pathogenicity Studies and Mitigation of Fish Infections
description	Aeromonas salmonicida subsp. salmonicida is a Gram-negative bacterium that causes furunculosis, a fish disease claiming substantial economic losses in the aquaculture industry. Major challenges exist in monitoring and controlling fish infections in aquaculture farms. Development of management practices to improve the sustainability of fish farming with disease prevention necessitates studies using well-defined systems and well-characterized bacterial isolates. Even though several A. salmonicida subsp. salmonicida genomes have been completely assembled and thoroughly annotated, in vivo pathogenicity data are lacking. Here we present A. salmonicida subsp. salmonicida 890054 as a prototype strain for standardized furunculosis challenges with survival data. Computational analysis of sequencing results provided a complete circular genome with annotations of plasmids carrying virulence factors, antimicrobial resistance, and secondary metabolite coding genes. The analysis also revealed the presence of an IncU plasmid distinct from other IncU plasmids previously associated with Aeromonas.
format	article
author	Jeff Gauthier Jeff Gauthier Jeff Gauthier Hélène Marquis Valérie E. Paquet Valérie E. Paquet Valérie E. Paquet Steve J. Charette Steve J. Charette Steve J. Charette Roger C. Levesque Roger C. Levesque Nicolas Derome Nicolas Derome
author_facet	Jeff Gauthier Jeff Gauthier Jeff Gauthier Hélène Marquis Valérie E. Paquet Valérie E. Paquet Valérie E. Paquet Steve J. Charette Steve J. Charette Steve J. Charette Roger C. Levesque Roger C. Levesque Nicolas Derome Nicolas Derome
author_sort	Jeff Gauthier
title	Genomic Perspectives on Aeromonas salmonicida subsp. salmonicida Strain 890054 as a Model System for Pathogenicity Studies and Mitigation of Fish Infections
title_short	Genomic Perspectives on Aeromonas salmonicida subsp. salmonicida Strain 890054 as a Model System for Pathogenicity Studies and Mitigation of Fish Infections
title_full	Genomic Perspectives on Aeromonas salmonicida subsp. salmonicida Strain 890054 as a Model System for Pathogenicity Studies and Mitigation of Fish Infections
title_fullStr	Genomic Perspectives on Aeromonas salmonicida subsp. salmonicida Strain 890054 as a Model System for Pathogenicity Studies and Mitigation of Fish Infections
title_full_unstemmed	Genomic Perspectives on Aeromonas salmonicida subsp. salmonicida Strain 890054 as a Model System for Pathogenicity Studies and Mitigation of Fish Infections
title_sort	genomic perspectives on aeromonas salmonicida subsp. salmonicida strain 890054 as a model system for pathogenicity studies and mitigation of fish infections
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7c5cf0000bd04b78ad77c93f158400e3
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Genomic Perspectives on Aeromonas salmonicida subsp. salmonicida Strain 890054 as a Model System for Pathogenicity Studies and Mitigation of Fish Infections

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