Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue

Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue

RNA Polymerase II can detect and cleave mis-incorporated nucleotides by a proofreading mechanism that requires backtracking of the enzyme. Here the authors show that Pol II backtracking occurs in a stepwise mode that involves two intermediate states where the fraying of the terminal RNA nucleotide i...

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Autores principales: Lin-Tai Da, Fátima Pardo-Avila, Liang Xu, Daniel-Adriano Silva, Lu Zhang, Xin Gao, Dong Wang, Xuhui Huang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/7c5fe7e083564141977609a05600aadc
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spelling oai:doaj.org-article:7c5fe7e083564141977609a05600aadc2021-12-02T14:38:33ZBridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue10.1038/ncomms112442041-1723https://doaj.org/article/7c5fe7e083564141977609a05600aadc2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11244https://doaj.org/toc/2041-1723RNA Polymerase II can detect and cleave mis-incorporated nucleotides by a proofreading mechanism that requires backtracking of the enzyme. Here the authors show that Pol II backtracking occurs in a stepwise mode that involves two intermediate states where the fraying of the terminal RNA nucleotide is a prerequisite.Lin-Tai DaFátima Pardo-AvilaLiang XuDaniel-Adriano SilvaLu ZhangXin GaoDong WangXuhui HuangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lin-Tai Da
Fátima Pardo-Avila
Liang Xu
Daniel-Adriano Silva
Lu Zhang
Xin Gao
Dong Wang
Xuhui Huang
Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue
description RNA Polymerase II can detect and cleave mis-incorporated nucleotides by a proofreading mechanism that requires backtracking of the enzyme. Here the authors show that Pol II backtracking occurs in a stepwise mode that involves two intermediate states where the fraying of the terminal RNA nucleotide is a prerequisite.
format article
author Lin-Tai Da
Fátima Pardo-Avila
Liang Xu
Daniel-Adriano Silva
Lu Zhang
Xin Gao
Dong Wang
Xuhui Huang
author_facet Lin-Tai Da
Fátima Pardo-Avila
Liang Xu
Daniel-Adriano Silva
Lu Zhang
Xin Gao
Dong Wang
Xuhui Huang
author_sort Lin-Tai Da
title Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue
title_short Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue
title_full Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue
title_fullStr Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue
title_full_unstemmed Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue
title_sort bridge helix bending promotes rna polymerase ii backtracking through a critical and conserved threonine residue
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/7c5fe7e083564141977609a05600aadc
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