OCT angiography metrics predict intradialytic hypotension episodes in chronic hemodialysis patients: a pilot, prospective study

Abstract In chronic hemodialysis (HD) patients, intradialytic hypotension (IDH) is a complication that increases mortality risk. We run a pilot study to analyzing possible relationships between optical coherence tomography angiography (OCT-A) metrics and IDH with the aim of evaluating if OCT-A could...

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Autores principales:	Giuseppe Coppolino, Adriano Carnevali, Valentina Gatti, Caterina Battaglia, Giorgio Randazzo, Irma Figlia, Gemma Patella, Giorgio Fuiano, Michele Andreucci, Giuseppe Giannaccare, Vincenzo Scorcia, Davide Bolignano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7c64b36413fe4f10895868f9a0e29d61
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spelling	oai:doaj.org-article:7c64b36413fe4f10895868f9a0e29d612021-12-02T13:26:37ZOCT angiography metrics predict intradialytic hypotension episodes in chronic hemodialysis patients: a pilot, prospective study10.1038/s41598-021-86609-02045-2322https://doaj.org/article/7c64b36413fe4f10895868f9a0e29d612021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86609-0https://doaj.org/toc/2045-2322Abstract In chronic hemodialysis (HD) patients, intradialytic hypotension (IDH) is a complication that increases mortality risk. We run a pilot study to analyzing possible relationships between optical coherence tomography angiography (OCT-A) metrics and IDH with the aim of evaluating if OCT-A could represent a useful tool to stratify the hypotensive risk in dialysis patients. A total of 35 eyes (35 patients) were analyzed. OCT-A was performed before and after a single dialysis session. We performed OCT-A 3 × 3 mm and 6 × 6 mm scanning area focused on the fovea centralis. Patients were then followed up to 30 days (10 HD sessions) and a total of 73 IDHs were recorded, with 12 patients (60%) experiencing at least one IDH. Different OCT-A parameters were reduced after dialysis: central choroid thickness (CCT), 6 × 6 mm foveal whole vessel density (VD) of superficial capillary plexus (SPC) and 6 × 6 mm foveal VD of deep capillary plexus (DCP). At logistic regression analysis, IDH was positively associated with baseline foveal VD of SCP and DCP, while an inverse association was found with the choroid. In Kaplan–Meier analyses of patients categorized according to the ROC-derived optimal thresholds, CCT, the 3 × 3 foveal VD of SCP, the 3 × 3 mm and 6 × 6 mm foveal VD of DCP and the 6 × 6 mm foveal VD of SCP were strongly associated with a higher risk of IDH over the 30-days follow-up. In HD patients, a single OCT-A measurement may represent a non-invasive, rapid tool to evaluate the compliance of vascular bed to HD stress and to stratify the risk of IDH in the short term.Giuseppe CoppolinoAdriano CarnevaliValentina GattiCaterina BattagliaGiorgio RandazzoIrma FigliaGemma PatellaGiorgio FuianoMichele AndreucciGiuseppe GiannaccareVincenzo ScorciaDavide BolignanoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Giuseppe Coppolino Adriano Carnevali Valentina Gatti Caterina Battaglia Giorgio Randazzo Irma Figlia Gemma Patella Giorgio Fuiano Michele Andreucci Giuseppe Giannaccare Vincenzo Scorcia Davide Bolignano OCT angiography metrics predict intradialytic hypotension episodes in chronic hemodialysis patients: a pilot, prospective study
description	Abstract In chronic hemodialysis (HD) patients, intradialytic hypotension (IDH) is a complication that increases mortality risk. We run a pilot study to analyzing possible relationships between optical coherence tomography angiography (OCT-A) metrics and IDH with the aim of evaluating if OCT-A could represent a useful tool to stratify the hypotensive risk in dialysis patients. A total of 35 eyes (35 patients) were analyzed. OCT-A was performed before and after a single dialysis session. We performed OCT-A 3 × 3 mm and 6 × 6 mm scanning area focused on the fovea centralis. Patients were then followed up to 30 days (10 HD sessions) and a total of 73 IDHs were recorded, with 12 patients (60%) experiencing at least one IDH. Different OCT-A parameters were reduced after dialysis: central choroid thickness (CCT), 6 × 6 mm foveal whole vessel density (VD) of superficial capillary plexus (SPC) and 6 × 6 mm foveal VD of deep capillary plexus (DCP). At logistic regression analysis, IDH was positively associated with baseline foveal VD of SCP and DCP, while an inverse association was found with the choroid. In Kaplan–Meier analyses of patients categorized according to the ROC-derived optimal thresholds, CCT, the 3 × 3 foveal VD of SCP, the 3 × 3 mm and 6 × 6 mm foveal VD of DCP and the 6 × 6 mm foveal VD of SCP were strongly associated with a higher risk of IDH over the 30-days follow-up. In HD patients, a single OCT-A measurement may represent a non-invasive, rapid tool to evaluate the compliance of vascular bed to HD stress and to stratify the risk of IDH in the short term.
format	article
author	Giuseppe Coppolino Adriano Carnevali Valentina Gatti Caterina Battaglia Giorgio Randazzo Irma Figlia Gemma Patella Giorgio Fuiano Michele Andreucci Giuseppe Giannaccare Vincenzo Scorcia Davide Bolignano
author_facet	Giuseppe Coppolino Adriano Carnevali Valentina Gatti Caterina Battaglia Giorgio Randazzo Irma Figlia Gemma Patella Giorgio Fuiano Michele Andreucci Giuseppe Giannaccare Vincenzo Scorcia Davide Bolignano
author_sort	Giuseppe Coppolino
title	OCT angiography metrics predict intradialytic hypotension episodes in chronic hemodialysis patients: a pilot, prospective study
title_short	OCT angiography metrics predict intradialytic hypotension episodes in chronic hemodialysis patients: a pilot, prospective study
title_full	OCT angiography metrics predict intradialytic hypotension episodes in chronic hemodialysis patients: a pilot, prospective study
title_fullStr	OCT angiography metrics predict intradialytic hypotension episodes in chronic hemodialysis patients: a pilot, prospective study
title_full_unstemmed	OCT angiography metrics predict intradialytic hypotension episodes in chronic hemodialysis patients: a pilot, prospective study
title_sort	oct angiography metrics predict intradialytic hypotension episodes in chronic hemodialysis patients: a pilot, prospective study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7c64b36413fe4f10895868f9a0e29d61
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OCT angiography metrics predict intradialytic hypotension episodes in chronic hemodialysis patients: a pilot, prospective study

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