Follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia

Rehab Nabil Shamma, Mona Hassan AburahmaDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, EgyptAbstract: Spironolactone (SL) is a US Food and Drug Administration-approved drug for the treatment of hypertension and various edematous condition...

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Autores principales: Shamma RN, Aburahma MH
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Publicado: Dove Medical Press 2014
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spelling oai:doaj.org-article:7c655fd69f81415da22950fdaacee8052021-12-02T02:40:32ZFollicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia1178-2013https://doaj.org/article/7c655fd69f81415da22950fdaacee8052014-11-01T00:00:00Zhttp://www.dovepress.com/follicular-delivery-of-spironolactone-via-nanostructured-lipid-carrier-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Rehab Nabil Shamma, Mona Hassan AburahmaDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, EgyptAbstract: Spironolactone (SL) is a US Food and Drug Administration-approved drug for the treatment of hypertension and various edematous conditions. SL has gained a lot of attention for treating androgenic alopecia due to its potent antiandrogenic properties. Recently, there has been growing interest for follicular targeting of drug molecules for treatment of hair and scalp disorders using nanocolloidal lipid-based delivery systems to minimize unnecessary systemic side effects associated with oral drug administration. Accordingly, the objective of this study is to improve SL efficiency and safety in treating alopecia through the preparation of colloidal nanostructured lipid carriers (NLCs) for follicular drug delivery. SL-loaded NLCs were prepared by an emulsion solvent diffusion and evaporation method using 23 full factorial design. All of the prepared formulations were spherical in shape with nanometric size range (215.6–834.3 nm) and entrapment efficiency >74%. Differential scanning calorimetry thermograms and X-ray diffractograms revealed that SL exists in amorphous form within the NLC matrices. The drug release behavior from the NLCs displayed an initial burst release phase followed by sustained release of SL. Confocal laser scanning microscopy confirmed the potential of delivering the fluorolabeled NLCs within the follicles, suggesting the possibility of using SL-loaded NLCs for localized delivery of SL into the scalp hair follicles.Keywords: spironolactone, androgenic alopecia, nanostructured lipid carriers, follicular targeting, confocal laser scanning microscopyShamma RNAburahma MHDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 5449-5460 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Shamma RN
Aburahma MH
Follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia
description Rehab Nabil Shamma, Mona Hassan AburahmaDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, EgyptAbstract: Spironolactone (SL) is a US Food and Drug Administration-approved drug for the treatment of hypertension and various edematous conditions. SL has gained a lot of attention for treating androgenic alopecia due to its potent antiandrogenic properties. Recently, there has been growing interest for follicular targeting of drug molecules for treatment of hair and scalp disorders using nanocolloidal lipid-based delivery systems to minimize unnecessary systemic side effects associated with oral drug administration. Accordingly, the objective of this study is to improve SL efficiency and safety in treating alopecia through the preparation of colloidal nanostructured lipid carriers (NLCs) for follicular drug delivery. SL-loaded NLCs were prepared by an emulsion solvent diffusion and evaporation method using 23 full factorial design. All of the prepared formulations were spherical in shape with nanometric size range (215.6–834.3 nm) and entrapment efficiency >74%. Differential scanning calorimetry thermograms and X-ray diffractograms revealed that SL exists in amorphous form within the NLC matrices. The drug release behavior from the NLCs displayed an initial burst release phase followed by sustained release of SL. Confocal laser scanning microscopy confirmed the potential of delivering the fluorolabeled NLCs within the follicles, suggesting the possibility of using SL-loaded NLCs for localized delivery of SL into the scalp hair follicles.Keywords: spironolactone, androgenic alopecia, nanostructured lipid carriers, follicular targeting, confocal laser scanning microscopy
format article
author Shamma RN
Aburahma MH
author_facet Shamma RN
Aburahma MH
author_sort Shamma RN
title Follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia
title_short Follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia
title_full Follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia
title_fullStr Follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia
title_full_unstemmed Follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia
title_sort follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/7c655fd69f81415da22950fdaacee805
work_keys_str_mv AT shammarn folliculardeliveryofspironolactoneviananostructuredlipidcarriersformanagementofnbspalopecia
AT aburahmamh folliculardeliveryofspironolactoneviananostructuredlipidcarriersformanagementofnbspalopecia
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