Synthesis of pH stable, blue light-emitting diode-excited, fluorescent silica nanoparticles and effects on cell behavior

Shin-Woo Ha,1 Jin-Kyu Lee,2 George R Beck Jr1,3,4 1Division of Endocrinology, Department of Medicine, Emory University, Atlanta, GA, USA; 2Department of Chemistry, Seoul National University, Seoul, South Korea; 3The Atlanta Department of Veterans Affairs Medical Center, Decatur, 4The Winship Cancer...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ha SW, Lee JK, Beck GR Jr
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Silica nanoparticles Blue LED Fluorescence Cell migration Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7c6dc3ce69dd47a68fdd4d2640ecab58
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7c6dc3ce69dd47a68fdd4d2640ecab58
record_format	dspace
spelling	oai:doaj.org-article:7c6dc3ce69dd47a68fdd4d2640ecab582021-12-02T01:04:57ZSynthesis of pH stable, blue light-emitting diode-excited, fluorescent silica nanoparticles and effects on cell behavior1178-2013https://doaj.org/article/7c6dc3ce69dd47a68fdd4d2640ecab582017-12-01T00:00:00Zhttps://www.dovepress.com/synthesis-of-ph-stable-blue-light-emitting-diode-excited-fluorescent---peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Shin-Woo Ha,1 Jin-Kyu Lee,2 George R Beck Jr1,3,4 1Division of Endocrinology, Department of Medicine, Emory University, Atlanta, GA, USA; 2Department of Chemistry, Seoul National University, Seoul, South Korea; 3The Atlanta Department of Veterans Affairs Medical Center, Decatur, 4The Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA Abstract: To date, delivery of light-emitting diode (LED)-activated compounds to cells and tissue remains a challenge. Silica-based materials possess good biocompatibility and have advantages of control of size and shape. Fluorescent silica nanoparticles (NPs) have been synthesized and used for applications such as cell tracking and tumor identification. Here, we report the synthesis and optimization of fluorescent silica NPs, which incorporate a naphthalimide dye with triethoxysilanes that are excited by the blue LED wavelength (LEDex NPs). The NPs can be imaged in the 420–470 nm wavelength, demonstrate a high quantum yield, are stable in a range of pH, and are taken into the cells. Therefore, these NPs represent a novel imaging technology for biomedical applications. Keywords: naphthalimide, imaging, bone marrow stromal cell migration, reduced toxicity Ha SWLee JKBeck GR JrDove Medical PressarticleSilica nanoparticlesBlue LEDFluorescenceCell migrationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 8699-8710 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Silica nanoparticles Blue LED Fluorescence Cell migration Medicine (General) R5-920
spellingShingle	Silica nanoparticles Blue LED Fluorescence Cell migration Medicine (General) R5-920 Ha SW Lee JK Beck GR Jr Synthesis of pH stable, blue light-emitting diode-excited, fluorescent silica nanoparticles and effects on cell behavior
description	Shin-Woo Ha,1 Jin-Kyu Lee,2 George R Beck Jr1,3,4 1Division of Endocrinology, Department of Medicine, Emory University, Atlanta, GA, USA; 2Department of Chemistry, Seoul National University, Seoul, South Korea; 3The Atlanta Department of Veterans Affairs Medical Center, Decatur, 4The Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA Abstract: To date, delivery of light-emitting diode (LED)-activated compounds to cells and tissue remains a challenge. Silica-based materials possess good biocompatibility and have advantages of control of size and shape. Fluorescent silica nanoparticles (NPs) have been synthesized and used for applications such as cell tracking and tumor identification. Here, we report the synthesis and optimization of fluorescent silica NPs, which incorporate a naphthalimide dye with triethoxysilanes that are excited by the blue LED wavelength (LEDex NPs). The NPs can be imaged in the 420–470 nm wavelength, demonstrate a high quantum yield, are stable in a range of pH, and are taken into the cells. Therefore, these NPs represent a novel imaging technology for biomedical applications. Keywords: naphthalimide, imaging, bone marrow stromal cell migration, reduced toxicity
format	article
author	Ha SW Lee JK Beck GR Jr
author_facet	Ha SW Lee JK Beck GR Jr
author_sort	Ha SW
title	Synthesis of pH stable, blue light-emitting diode-excited, fluorescent silica nanoparticles and effects on cell behavior
title_short	Synthesis of pH stable, blue light-emitting diode-excited, fluorescent silica nanoparticles and effects on cell behavior
title_full	Synthesis of pH stable, blue light-emitting diode-excited, fluorescent silica nanoparticles and effects on cell behavior
title_fullStr	Synthesis of pH stable, blue light-emitting diode-excited, fluorescent silica nanoparticles and effects on cell behavior
title_full_unstemmed	Synthesis of pH stable, blue light-emitting diode-excited, fluorescent silica nanoparticles and effects on cell behavior
title_sort	synthesis of ph stable, blue light-emitting diode-excited, fluorescent silica nanoparticles and effects on cell behavior
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/7c6dc3ce69dd47a68fdd4d2640ecab58
work_keys_str_mv	AT hasw synthesisofphstablebluelightemittingdiodeexcitedfluorescentsilicananoparticlesandeffectsoncellbehavior AT leejk synthesisofphstablebluelightemittingdiodeexcitedfluorescentsilicananoparticlesandeffectsoncellbehavior AT beckgrjr synthesisofphstablebluelightemittingdiodeexcitedfluorescentsilicananoparticlesandeffectsoncellbehavior
_version_	1718403324625027072

Synthesis of pH stable, blue light-emitting diode-excited, fluorescent silica nanoparticles and effects on cell behavior

Ejemplares similares