Novel platinum–palladium bimetallic nanoparticles synthesized by Dioscorea bulbifera: anticancer and antioxidant activities

Novel platinum–palladium bimetallic nanoparticles synthesized by Dioscorea bulbifera: anticancer and antioxidant activities

Sougata Ghosh,1 Rahul Nitnavare,1 Ankush Dewle,1 Geetanjali B Tomar,1 Rohan Chippalkatti,1 Piyush More,1 Rohini Kitture,2 Sangeeta Kale,2 Jayesh Bellare,3 Balu A Chopade4 1Institute of Bioinformatics and Biotechnology, University of Pune, 2Department of Applied Physics, Defense Institute of Advance...

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Autores principales: Ghosh S, Nitnavare R, Dewle A, Tomar GB, Chippalkatti R, More P, Kitture R, Kale S, Bellare J, Chopade BA
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
Materias:
Dioscorea bulbifera
platinum nanoparticles
palladium nanoparticles
platinum-palladium bimetallic nanoparticles
anticancer
antioxidant.
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/7c6eafc996a14dc7b3ad23213ee08495
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spelling oai:doaj.org-article:7c6eafc996a14dc7b3ad23213ee084952021-12-02T04:28:15ZNovel platinum–palladium bimetallic nanoparticles synthesized by Dioscorea bulbifera: anticancer and antioxidant activities1178-2013https://doaj.org/article/7c6eafc996a14dc7b3ad23213ee084952015-12-01T00:00:00Zhttps://www.dovepress.com/novel-platinumndashpalladium-bimetallic-nanoparticles-synthesized-by-d-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Sougata Ghosh,1 Rahul Nitnavare,1 Ankush Dewle,1 Geetanjali B Tomar,1 Rohan Chippalkatti,1 Piyush More,1 Rohini Kitture,2 Sangeeta Kale,2 Jayesh Bellare,3 Balu A Chopade4 1Institute of Bioinformatics and Biotechnology, University of Pune, 2Department of Applied Physics, Defense Institute of Advanced Technology, Pune, 3Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai, 4Department of Microbiology, University of Pune, Pune, India Abstract: Medicinal plants serve as rich sources of diverse bioactive phytochemicals that might even take part in bioreduction and stabilization of phytogenic nanoparticles with immense therapeutic properties. Herein, we report for the first time the rapid efficient synthesis of novel platinum–palladium bimetallic nanoparticles (Pt–PdNPs) along with individual platinum (PtNPs) and palladium (PdNPs) nanoparticles using a medicinal plant, Dioscorea bulbifera tuber extract (DBTE). High-resolution transmission electron microscopy revealed monodispersed PtNPs of size 2–5 nm, while PdNPs and Pt–PdNPs between 10 and 25 nm. Energy dispersive spectroscopy analysis confirmed 30.88%±1.73% elemental Pt and 68.96%±1.48% elemental Pd in the bimetallic nanoparticles. Fourier transform infrared spectra indicated strong peaks at 3,373 cm-1, attributed to hydroxyl group of polyphenolic compounds in DBTE that might play a key role in bioreduction in addition to the sharp peaks at 2,937, 1,647, 1,518, and 1,024 cm-1, associated with C–H stretching, N–H bending in primary amines, N–O stretching in nitro group, and C–C stretch, respectively. Anticancer activity against HeLa cells showed that Pt–PdNPs exhibited more pronounced cell death of 74.25% compared to individual PtNPs (12.6%) or PdNPs (33.15%). Further, Pt–PdNPs showed an enhanced scavenging activity against 2,2-diphenyl-1-picrylhydrazyl, superoxide, nitric oxide, and hydroxyl radicals. Keywords: Dioscorea bulbifera, platinum nanoparticles, palladium nanoparticles, platinum–palladium bimetallic nanoparticles, anticancer, antioxidantGhosh SNitnavare RDewle ATomar GBChippalkatti RMore PKitture RKale SBellare JChopade BADove Medical PressarticleDioscorea bulbiferaplatinum nanoparticlespalladium nanoparticlesplatinum-palladium bimetallic nanoparticlesanticancerantioxidant.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 7477-7490 (2015)
institution DOAJ
collection DOAJ
language EN
topic Dioscorea bulbifera
platinum nanoparticles
palladium nanoparticles
platinum-palladium bimetallic nanoparticles
anticancer
antioxidant.
Medicine (General)
R5-920
spellingShingle Dioscorea bulbifera
platinum nanoparticles
palladium nanoparticles
platinum-palladium bimetallic nanoparticles
anticancer
antioxidant.
Medicine (General)
R5-920
Ghosh S
Nitnavare R
Dewle A
Tomar GB
Chippalkatti R
More P
Kitture R
Kale S
Bellare J
Chopade BA
Novel platinum–palladium bimetallic nanoparticles synthesized by Dioscorea bulbifera: anticancer and antioxidant activities
description Sougata Ghosh,1 Rahul Nitnavare,1 Ankush Dewle,1 Geetanjali B Tomar,1 Rohan Chippalkatti,1 Piyush More,1 Rohini Kitture,2 Sangeeta Kale,2 Jayesh Bellare,3 Balu A Chopade4 1Institute of Bioinformatics and Biotechnology, University of Pune, 2Department of Applied Physics, Defense Institute of Advanced Technology, Pune, 3Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai, 4Department of Microbiology, University of Pune, Pune, India Abstract: Medicinal plants serve as rich sources of diverse bioactive phytochemicals that might even take part in bioreduction and stabilization of phytogenic nanoparticles with immense therapeutic properties. Herein, we report for the first time the rapid efficient synthesis of novel platinum–palladium bimetallic nanoparticles (Pt–PdNPs) along with individual platinum (PtNPs) and palladium (PdNPs) nanoparticles using a medicinal plant, Dioscorea bulbifera tuber extract (DBTE). High-resolution transmission electron microscopy revealed monodispersed PtNPs of size 2–5 nm, while PdNPs and Pt–PdNPs between 10 and 25 nm. Energy dispersive spectroscopy analysis confirmed 30.88%±1.73% elemental Pt and 68.96%±1.48% elemental Pd in the bimetallic nanoparticles. Fourier transform infrared spectra indicated strong peaks at 3,373 cm-1, attributed to hydroxyl group of polyphenolic compounds in DBTE that might play a key role in bioreduction in addition to the sharp peaks at 2,937, 1,647, 1,518, and 1,024 cm-1, associated with C–H stretching, N–H bending in primary amines, N–O stretching in nitro group, and C–C stretch, respectively. Anticancer activity against HeLa cells showed that Pt–PdNPs exhibited more pronounced cell death of 74.25% compared to individual PtNPs (12.6%) or PdNPs (33.15%). Further, Pt–PdNPs showed an enhanced scavenging activity against 2,2-diphenyl-1-picrylhydrazyl, superoxide, nitric oxide, and hydroxyl radicals. Keywords: Dioscorea bulbifera, platinum nanoparticles, palladium nanoparticles, platinum–palladium bimetallic nanoparticles, anticancer, antioxidant
format article
author Ghosh S
Nitnavare R
Dewle A
Tomar GB
Chippalkatti R
More P
Kitture R
Kale S
Bellare J
Chopade BA
author_facet Ghosh S
Nitnavare R
Dewle A
Tomar GB
Chippalkatti R
More P
Kitture R
Kale S
Bellare J
Chopade BA
author_sort Ghosh S
title Novel platinum–palladium bimetallic nanoparticles synthesized by Dioscorea bulbifera: anticancer and antioxidant activities
title_short Novel platinum–palladium bimetallic nanoparticles synthesized by Dioscorea bulbifera: anticancer and antioxidant activities
title_full Novel platinum–palladium bimetallic nanoparticles synthesized by Dioscorea bulbifera: anticancer and antioxidant activities
title_fullStr Novel platinum–palladium bimetallic nanoparticles synthesized by Dioscorea bulbifera: anticancer and antioxidant activities
title_full_unstemmed Novel platinum–palladium bimetallic nanoparticles synthesized by Dioscorea bulbifera: anticancer and antioxidant activities
title_sort novel platinum–palladium bimetallic nanoparticles synthesized by dioscorea bulbifera: anticancer and antioxidant activities
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/7c6eafc996a14dc7b3ad23213ee08495
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