Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors

Although Capicua (Cic), a transcriptional repressor, is linked to cancer, little is known about its function in the non-diseased brain. Here, authors show that Cic is strongly expressed in astrocytic and neuronal lineage cells during development and regulates proliferation and lineage selection via...

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Autores principales:	Shiekh Tanveer Ahmad, Alexandra D. Rogers, Myra J. Chen, Rajiv Dixit, Lata Adnani, Luke S. Frankiw, Samuel O. Lawn, Michael D. Blough, Mana Alshehri, Wei Wu, Marco A. Marra, Stephen M. Robbins, J. Gregory Cairncross, Carol Schuurmans, Jennifer A. Chan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7c701ae587344f44b0639d92de89cde9
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spelling	oai:doaj.org-article:7c701ae587344f44b0639d92de89cde92021-12-02T16:57:35ZCapicua regulates neural stem cell proliferation and lineage specification through control of Ets factors10.1038/s41467-019-09949-62041-1723https://doaj.org/article/7c701ae587344f44b0639d92de89cde92019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09949-6https://doaj.org/toc/2041-1723Although Capicua (Cic), a transcriptional repressor, is linked to cancer, little is known about its function in the non-diseased brain. Here, authors show that Cic is strongly expressed in astrocytic and neuronal lineage cells during development and regulates proliferation and lineage selection via de-repression of Ets transcription factors.Shiekh Tanveer AhmadAlexandra D. RogersMyra J. ChenRajiv DixitLata AdnaniLuke S. FrankiwSamuel O. LawnMichael D. BloughMana AlshehriWei WuMarco A. MarraStephen M. RobbinsJ. Gregory CairncrossCarol SchuurmansJennifer A. ChanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shiekh Tanveer Ahmad Alexandra D. Rogers Myra J. Chen Rajiv Dixit Lata Adnani Luke S. Frankiw Samuel O. Lawn Michael D. Blough Mana Alshehri Wei Wu Marco A. Marra Stephen M. Robbins J. Gregory Cairncross Carol Schuurmans Jennifer A. Chan Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors
description	Although Capicua (Cic), a transcriptional repressor, is linked to cancer, little is known about its function in the non-diseased brain. Here, authors show that Cic is strongly expressed in astrocytic and neuronal lineage cells during development and regulates proliferation and lineage selection via de-repression of Ets transcription factors.
format	article
author	Shiekh Tanveer Ahmad Alexandra D. Rogers Myra J. Chen Rajiv Dixit Lata Adnani Luke S. Frankiw Samuel O. Lawn Michael D. Blough Mana Alshehri Wei Wu Marco A. Marra Stephen M. Robbins J. Gregory Cairncross Carol Schuurmans Jennifer A. Chan
author_facet	Shiekh Tanveer Ahmad Alexandra D. Rogers Myra J. Chen Rajiv Dixit Lata Adnani Luke S. Frankiw Samuel O. Lawn Michael D. Blough Mana Alshehri Wei Wu Marco A. Marra Stephen M. Robbins J. Gregory Cairncross Carol Schuurmans Jennifer A. Chan
author_sort	Shiekh Tanveer Ahmad
title	Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors
title_short	Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors
title_full	Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors
title_fullStr	Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors
title_full_unstemmed	Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors
title_sort	capicua regulates neural stem cell proliferation and lineage specification through control of ets factors
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7c701ae587344f44b0639d92de89cde9
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Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors

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