Lepra Bubalorum, a Potential Reservoir of Mycobacterium leprae

In 1926, a mycobacterial skin disease was observed in water buffaloes by researchers in Indonesia. The disease was designated as skin tuberculosis, though it was hypothesized that it might be a form of leprosy or a leprosy-like disease. In a follow-up study (Ph.D. thesis Lobel, 1934, Utrecht Univers...

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Autores principales:	William R. Faber, Henk Menke, Victor Rutten, Toine Pieters
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	M. leprae M. leprae complex lepra bubalorum Indonesia animal reservoir water buffaloes Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/7c7055080da84da0ab27edbb2143c3c0
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id	oai:doaj.org-article:7c7055080da84da0ab27edbb2143c3c0
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spelling	oai:doaj.org-article:7c7055080da84da0ab27edbb2143c3c02021-12-02T10:01:14ZLepra Bubalorum, a Potential Reservoir of Mycobacterium leprae1664-302X10.3389/fmicb.2021.786921https://doaj.org/article/7c7055080da84da0ab27edbb2143c3c02021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmicb.2021.786921/fullhttps://doaj.org/toc/1664-302XIn 1926, a mycobacterial skin disease was observed in water buffaloes by researchers in Indonesia. The disease was designated as skin tuberculosis, though it was hypothesized that it might be a form of leprosy or a leprosy-like disease. In a follow-up study (Ph.D. thesis Lobel, 1934, Utrecht University, Netherlands) a similar nodular skin disease was described in Indonesian water buffaloes and named “lepra bubalorum” or “nodular leprosy.” Two decades later Kraneveld and Roza (1954) reported that, so far, the diagnosis lepra bubalorum had been made in 146 cases in Indonesia. After a final series of research reports by Indonesian veterinarians in 1961, no subsequent cases were published. Based on information from these reports, it can be concluded that, even though evidence of nerve involvement in buffaloes was not reported, similarities exist between lepra bubalorum and Hansen’s disease (leprosy), i.e., nodular skin lesions with a chronic course and microscopically granulomatous reactions with AFB in globi in vacuoles. This raises the question as to whether these historical cases might indeed have been caused by Mycobacterium leprae, Mycobacterium lepromatosis or another representative of the M. leprae complex. The future use of state-of-the-art molecular techniques may answer this question and may also help to answer the question whether water buffaloes should be considered as a potential natural reservoir of the causative pathogen of Hansen’s disease.William R. FaberHenk MenkeVictor RuttenVictor RuttenToine PietersFrontiers Media S.A.articleM. lepraeM. leprae complexlepra bubalorumIndonesiaanimal reservoirwater buffaloesMicrobiologyQR1-502ENFrontiers in Microbiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	M. leprae M. leprae complex lepra bubalorum Indonesia animal reservoir water buffaloes Microbiology QR1-502
spellingShingle	M. leprae M. leprae complex lepra bubalorum Indonesia animal reservoir water buffaloes Microbiology QR1-502 William R. Faber Henk Menke Victor Rutten Victor Rutten Toine Pieters Lepra Bubalorum, a Potential Reservoir of Mycobacterium leprae
description	In 1926, a mycobacterial skin disease was observed in water buffaloes by researchers in Indonesia. The disease was designated as skin tuberculosis, though it was hypothesized that it might be a form of leprosy or a leprosy-like disease. In a follow-up study (Ph.D. thesis Lobel, 1934, Utrecht University, Netherlands) a similar nodular skin disease was described in Indonesian water buffaloes and named “lepra bubalorum” or “nodular leprosy.” Two decades later Kraneveld and Roza (1954) reported that, so far, the diagnosis lepra bubalorum had been made in 146 cases in Indonesia. After a final series of research reports by Indonesian veterinarians in 1961, no subsequent cases were published. Based on information from these reports, it can be concluded that, even though evidence of nerve involvement in buffaloes was not reported, similarities exist between lepra bubalorum and Hansen’s disease (leprosy), i.e., nodular skin lesions with a chronic course and microscopically granulomatous reactions with AFB in globi in vacuoles. This raises the question as to whether these historical cases might indeed have been caused by Mycobacterium leprae, Mycobacterium lepromatosis or another representative of the M. leprae complex. The future use of state-of-the-art molecular techniques may answer this question and may also help to answer the question whether water buffaloes should be considered as a potential natural reservoir of the causative pathogen of Hansen’s disease.
format	article
author	William R. Faber Henk Menke Victor Rutten Victor Rutten Toine Pieters
author_facet	William R. Faber Henk Menke Victor Rutten Victor Rutten Toine Pieters
author_sort	William R. Faber
title	Lepra Bubalorum, a Potential Reservoir of Mycobacterium leprae
title_short	Lepra Bubalorum, a Potential Reservoir of Mycobacterium leprae
title_full	Lepra Bubalorum, a Potential Reservoir of Mycobacterium leprae
title_fullStr	Lepra Bubalorum, a Potential Reservoir of Mycobacterium leprae
title_full_unstemmed	Lepra Bubalorum, a Potential Reservoir of Mycobacterium leprae
title_sort	lepra bubalorum, a potential reservoir of mycobacterium leprae
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7c7055080da84da0ab27edbb2143c3c0
work_keys_str_mv	AT williamrfaber leprabubalorumapotentialreservoirofmycobacteriumleprae AT henkmenke leprabubalorumapotentialreservoirofmycobacteriumleprae AT victorrutten leprabubalorumapotentialreservoirofmycobacteriumleprae AT victorrutten leprabubalorumapotentialreservoirofmycobacteriumleprae AT toinepieters leprabubalorumapotentialreservoirofmycobacteriumleprae
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Lepra Bubalorum, a Potential Reservoir of Mycobacterium leprae

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