Tumor-Progressive Mechanisms Mediating miRNA–Protein Interaction

MicroRNAs (miRNAs) are single-stranded short-chain RNAs that are endogenously expressed in vertebrates; they are considered the fine-tuners of cellular protein expression that act by modifying mRNA translation. miRNAs control tissue development and differentiation, cell growth, and apoptosis in canc...

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Autores principales:	Hiroaki Konishi, Hiroki Sato, Kenji Takahashi, Mikihiro Fujiya
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	microRNA RNA-binding protein cancer therapy Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/7c71271d135449329031dda9ddc863a8
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id	oai:doaj.org-article:7c71271d135449329031dda9ddc863a8
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spelling	oai:doaj.org-article:7c71271d135449329031dda9ddc863a82021-11-25T17:55:15ZTumor-Progressive Mechanisms Mediating miRNA–Protein Interaction10.3390/ijms2222123031422-00671661-6596https://doaj.org/article/7c71271d135449329031dda9ddc863a82021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12303https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067MicroRNAs (miRNAs) are single-stranded short-chain RNAs that are endogenously expressed in vertebrates; they are considered the fine-tuners of cellular protein expression that act by modifying mRNA translation. miRNAs control tissue development and differentiation, cell growth, and apoptosis in cancer and non-cancer cells. Aberrant regulation of miRNAs is involved in the pathogenesis of various diseases including cancer. Numerous investigations have shown that the changes in cellular miRNA expression in cancerous tissues and extracellular miRNAs enclosed in exosomes are correlated with cancer prognosis. Therefore, miRNAs can be used as cancer biomarkers and therapeutic targets for cancer in clinical applications. In the previous decade, miRNAs have been shown to regulate cellular functions by directly binding to proteins and mRNAs, thereby controlling cancer progression. This regulatory system implies that cancer-associated miRNAs can be applied as molecular-targeted therapy. This review discusses the roles of miRNA–protein systems in cancer progression and its future applications in cancer treatment.Hiroaki KonishiHiroki SatoKenji TakahashiMikihiro FujiyaMDPI AGarticlemicroRNARNA-binding proteincancer therapyBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12303, p 12303 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microRNA RNA-binding protein cancer therapy Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	microRNA RNA-binding protein cancer therapy Biology (General) QH301-705.5 Chemistry QD1-999 Hiroaki Konishi Hiroki Sato Kenji Takahashi Mikihiro Fujiya Tumor-Progressive Mechanisms Mediating miRNA–Protein Interaction
description	MicroRNAs (miRNAs) are single-stranded short-chain RNAs that are endogenously expressed in vertebrates; they are considered the fine-tuners of cellular protein expression that act by modifying mRNA translation. miRNAs control tissue development and differentiation, cell growth, and apoptosis in cancer and non-cancer cells. Aberrant regulation of miRNAs is involved in the pathogenesis of various diseases including cancer. Numerous investigations have shown that the changes in cellular miRNA expression in cancerous tissues and extracellular miRNAs enclosed in exosomes are correlated with cancer prognosis. Therefore, miRNAs can be used as cancer biomarkers and therapeutic targets for cancer in clinical applications. In the previous decade, miRNAs have been shown to regulate cellular functions by directly binding to proteins and mRNAs, thereby controlling cancer progression. This regulatory system implies that cancer-associated miRNAs can be applied as molecular-targeted therapy. This review discusses the roles of miRNA–protein systems in cancer progression and its future applications in cancer treatment.
format	article
author	Hiroaki Konishi Hiroki Sato Kenji Takahashi Mikihiro Fujiya
author_facet	Hiroaki Konishi Hiroki Sato Kenji Takahashi Mikihiro Fujiya
author_sort	Hiroaki Konishi
title	Tumor-Progressive Mechanisms Mediating miRNA–Protein Interaction
title_short	Tumor-Progressive Mechanisms Mediating miRNA–Protein Interaction
title_full	Tumor-Progressive Mechanisms Mediating miRNA–Protein Interaction
title_fullStr	Tumor-Progressive Mechanisms Mediating miRNA–Protein Interaction
title_full_unstemmed	Tumor-Progressive Mechanisms Mediating miRNA–Protein Interaction
title_sort	tumor-progressive mechanisms mediating mirna–protein interaction
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7c71271d135449329031dda9ddc863a8
work_keys_str_mv	AT hiroakikonishi tumorprogressivemechanismsmediatingmirnaproteininteraction AT hirokisato tumorprogressivemechanismsmediatingmirnaproteininteraction AT kenjitakahashi tumorprogressivemechanismsmediatingmirnaproteininteraction AT mikihirofujiya tumorprogressivemechanismsmediatingmirnaproteininteraction
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Tumor-Progressive Mechanisms Mediating miRNA–Protein Interaction

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