First description of behavior and immune system relationship in fish

Abstract Considering the intriguing relationship between immune system and behavior recently described in mammals, and the lack of information of this relationship in fish, here we describe for the first time the interaction between the immune system and social and exploratory behavior in zebrafish....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Karina Kirsten, Débora Fior, Luiz Carlos Kreutz, Leonardo José Gil Barcellos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7c72b8df372d4972976a7e01e3ad0f2a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7c72b8df372d4972976a7e01e3ad0f2a
record_format	dspace
spelling	oai:doaj.org-article:7c72b8df372d4972976a7e01e3ad0f2a2021-12-02T15:08:16ZFirst description of behavior and immune system relationship in fish10.1038/s41598-018-19276-32045-2322https://doaj.org/article/7c72b8df372d4972976a7e01e3ad0f2a2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19276-3https://doaj.org/toc/2045-2322Abstract Considering the intriguing relationship between immune system and behavior recently described in mammals, and the lack of information of this relationship in fish, here we describe for the first time the interaction between the immune system and social and exploratory behavior in zebrafish. Fish high responders to novelty (HRN) presented a proinflammatory profile, with increased IL-1β and reduced IL-10 expression compared to fish low responders to novelty (LRN). Likewise, fish less responsive to social stimuli have a reduced expression of INF-γ. We show that fish with different behavior patterns have differences in the immune response. Our findings indicate that the interplay between immune system and behavior in zebrafish is similar to that found in mammalian models and that zebrafish should be considered as a potential model organism to study the relationship between immune system and behavior.Karina KirstenDébora FiorLuiz Carlos KreutzLeonardo José Gil BarcellosNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Karina Kirsten Débora Fior Luiz Carlos Kreutz Leonardo José Gil Barcellos First description of behavior and immune system relationship in fish
description	Abstract Considering the intriguing relationship between immune system and behavior recently described in mammals, and the lack of information of this relationship in fish, here we describe for the first time the interaction between the immune system and social and exploratory behavior in zebrafish. Fish high responders to novelty (HRN) presented a proinflammatory profile, with increased IL-1β and reduced IL-10 expression compared to fish low responders to novelty (LRN). Likewise, fish less responsive to social stimuli have a reduced expression of INF-γ. We show that fish with different behavior patterns have differences in the immune response. Our findings indicate that the interplay between immune system and behavior in zebrafish is similar to that found in mammalian models and that zebrafish should be considered as a potential model organism to study the relationship between immune system and behavior.
format	article
author	Karina Kirsten Débora Fior Luiz Carlos Kreutz Leonardo José Gil Barcellos
author_facet	Karina Kirsten Débora Fior Luiz Carlos Kreutz Leonardo José Gil Barcellos
author_sort	Karina Kirsten
title	First description of behavior and immune system relationship in fish
title_short	First description of behavior and immune system relationship in fish
title_full	First description of behavior and immune system relationship in fish
title_fullStr	First description of behavior and immune system relationship in fish
title_full_unstemmed	First description of behavior and immune system relationship in fish
title_sort	first description of behavior and immune system relationship in fish
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7c72b8df372d4972976a7e01e3ad0f2a
work_keys_str_mv	AT karinakirsten firstdescriptionofbehaviorandimmunesystemrelationshipinfish AT deborafior firstdescriptionofbehaviorandimmunesystemrelationshipinfish AT luizcarloskreutz firstdescriptionofbehaviorandimmunesystemrelationshipinfish AT leonardojosegilbarcellos firstdescriptionofbehaviorandimmunesystemrelationshipinfish
_version_	1718388196368187392

First description of behavior and immune system relationship in fish

Ejemplares similares