NSAID use is not associated with Parkinson's disease incidence: A Norwegian Prescription Database study.

<h4>Objective</h4>Whether use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of incident Parkinson's disease (PD) remains unresolved. Here, we employed the Norwegian Prescription Database to examine whether NSAID use is associated with a lower incidence of PD.<h...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Brage Brakedal, Charalampos Tzoulis, Ole-Bjørn Tysnes, Kristoffer Haugarvoll
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7c73052c32f6488dbfdc3dbdd94c312b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7c73052c32f6488dbfdc3dbdd94c312b
record_format	dspace
spelling	oai:doaj.org-article:7c73052c32f6488dbfdc3dbdd94c312b2021-12-02T20:08:27ZNSAID use is not associated with Parkinson's disease incidence: A Norwegian Prescription Database study.1932-620310.1371/journal.pone.0256602https://doaj.org/article/7c73052c32f6488dbfdc3dbdd94c312b2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256602https://doaj.org/toc/1932-6203<h4>Objective</h4>Whether use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of incident Parkinson's disease (PD) remains unresolved. Here, we employed the Norwegian Prescription Database to examine whether NSAID use is associated with a lower incidence of PD.<h4>Methods</h4>We compared the incidence of PD among users of NSAIDs in a population-based retrospective study using the Norwegian Prescription Database from 2004 to 2017. In total 7580 PD patients were identified using dopaminergic therapy over time as proxy for PD diagnosis. Analyses were performed with minimum 90 and 365 defined daily dose (DDD) NSAID exposure, respectively. Time-dependent Cox regression model and a binary logistic regression analysis with a 5-year lag until PD diagnosis were performed for all NSAIDs.<h4>Results</h4>There was overall no decrease in incidence of PD among NSAID users compared to controls. Using a minimum of 90 or 365 DDD threshold of exposure produced similar results. Analysis of individual NSAIDs did not show difference in PD incidence compared to controls Age-specific incidence rates of PD were comparable to reported age-specific incidence rates in previous studies.<h4>Interpretation</h4>Our findings provide no evidence that cumulative high exposure to NSAIDs affects the risk of developing PD.Brage BrakedalCharalampos TzoulisOle-Bjørn TysnesKristoffer HaugarvollPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0256602 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Brage Brakedal Charalampos Tzoulis Ole-Bjørn Tysnes Kristoffer Haugarvoll NSAID use is not associated with Parkinson's disease incidence: A Norwegian Prescription Database study.
description	<h4>Objective</h4>Whether use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of incident Parkinson's disease (PD) remains unresolved. Here, we employed the Norwegian Prescription Database to examine whether NSAID use is associated with a lower incidence of PD.<h4>Methods</h4>We compared the incidence of PD among users of NSAIDs in a population-based retrospective study using the Norwegian Prescription Database from 2004 to 2017. In total 7580 PD patients were identified using dopaminergic therapy over time as proxy for PD diagnosis. Analyses were performed with minimum 90 and 365 defined daily dose (DDD) NSAID exposure, respectively. Time-dependent Cox regression model and a binary logistic regression analysis with a 5-year lag until PD diagnosis were performed for all NSAIDs.<h4>Results</h4>There was overall no decrease in incidence of PD among NSAID users compared to controls. Using a minimum of 90 or 365 DDD threshold of exposure produced similar results. Analysis of individual NSAIDs did not show difference in PD incidence compared to controls Age-specific incidence rates of PD were comparable to reported age-specific incidence rates in previous studies.<h4>Interpretation</h4>Our findings provide no evidence that cumulative high exposure to NSAIDs affects the risk of developing PD.
format	article
author	Brage Brakedal Charalampos Tzoulis Ole-Bjørn Tysnes Kristoffer Haugarvoll
author_facet	Brage Brakedal Charalampos Tzoulis Ole-Bjørn Tysnes Kristoffer Haugarvoll
author_sort	Brage Brakedal
title	NSAID use is not associated with Parkinson's disease incidence: A Norwegian Prescription Database study.
title_short	NSAID use is not associated with Parkinson's disease incidence: A Norwegian Prescription Database study.
title_full	NSAID use is not associated with Parkinson's disease incidence: A Norwegian Prescription Database study.
title_fullStr	NSAID use is not associated with Parkinson's disease incidence: A Norwegian Prescription Database study.
title_full_unstemmed	NSAID use is not associated with Parkinson's disease incidence: A Norwegian Prescription Database study.
title_sort	nsaid use is not associated with parkinson's disease incidence: a norwegian prescription database study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/7c73052c32f6488dbfdc3dbdd94c312b
work_keys_str_mv	AT bragebrakedal nsaiduseisnotassociatedwithparkinsonsdiseaseincidenceanorwegianprescriptiondatabasestudy AT charalampostzoulis nsaiduseisnotassociatedwithparkinsonsdiseaseincidenceanorwegianprescriptiondatabasestudy AT olebjørntysnes nsaiduseisnotassociatedwithparkinsonsdiseaseincidenceanorwegianprescriptiondatabasestudy AT kristofferhaugarvoll nsaiduseisnotassociatedwithparkinsonsdiseaseincidenceanorwegianprescriptiondatabasestudy
_version_	1718375191265935360

NSAID use is not associated with Parkinson's disease incidence: A Norwegian Prescription Database study.

Ejemplares similares