ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1

Resistance to receptor tyrosine kinase inhibitors is a major obstacle in treatment of lung adenocarcinoma. Yamaguchi et al.identify the orphan receptor ROR1 as a potential target to overcome this resistance, by virtue of its role in promoting cell survival through stabilisation of caveolae.

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Autores principales:	Tomoya Yamaguchi, Can Lu, Lisa Ida, Kiyoshi Yanagisawa, Jiro Usukura, Jinglei Cheng, Naoe Hotta, Yukako Shimada, Hisanori Isomura, Motoshi Suzuki, Toyoshi Fujimoto, Takashi Takahashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7c75a87e81e0429b80dd4b3a91b33ba8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7c75a87e81e0429b80dd4b3a91b33ba8
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spelling	oai:doaj.org-article:7c75a87e81e0429b80dd4b3a91b33ba82021-12-02T14:39:52ZROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-110.1038/ncomms100602041-1723https://doaj.org/article/7c75a87e81e0429b80dd4b3a91b33ba82016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10060https://doaj.org/toc/2041-1723Resistance to receptor tyrosine kinase inhibitors is a major obstacle in treatment of lung adenocarcinoma. Yamaguchi et al.identify the orphan receptor ROR1 as a potential target to overcome this resistance, by virtue of its role in promoting cell survival through stabilisation of caveolae.Tomoya YamaguchiCan LuLisa IdaKiyoshi YanagisawaJiro UsukuraJinglei ChengNaoe HottaYukako ShimadaHisanori IsomuraMotoshi SuzukiToyoshi FujimotoTakashi TakahashiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tomoya Yamaguchi Can Lu Lisa Ida Kiyoshi Yanagisawa Jiro Usukura Jinglei Cheng Naoe Hotta Yukako Shimada Hisanori Isomura Motoshi Suzuki Toyoshi Fujimoto Takashi Takahashi ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1
description	Resistance to receptor tyrosine kinase inhibitors is a major obstacle in treatment of lung adenocarcinoma. Yamaguchi et al.identify the orphan receptor ROR1 as a potential target to overcome this resistance, by virtue of its role in promoting cell survival through stabilisation of caveolae.
format	article
author	Tomoya Yamaguchi Can Lu Lisa Ida Kiyoshi Yanagisawa Jiro Usukura Jinglei Cheng Naoe Hotta Yukako Shimada Hisanori Isomura Motoshi Suzuki Toyoshi Fujimoto Takashi Takahashi
author_facet	Tomoya Yamaguchi Can Lu Lisa Ida Kiyoshi Yanagisawa Jiro Usukura Jinglei Cheng Naoe Hotta Yukako Shimada Hisanori Isomura Motoshi Suzuki Toyoshi Fujimoto Takashi Takahashi
author_sort	Tomoya Yamaguchi
title	ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1
title_short	ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1
title_full	ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1
title_fullStr	ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1
title_full_unstemmed	ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1
title_sort	ror1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7c75a87e81e0429b80dd4b3a91b33ba8
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ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1

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