Interethnic analyses of blood pressure loci in populations of East Asian and European descent
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, the authors perform discovery GWAS for BP in East Asians and meta-analysis in East Asians and Europeans and report ancestry-specific BP SNPs and selection signals.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2018
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/7c763ccbcec74bc6b4f1c9dd802eadad |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:7c763ccbcec74bc6b4f1c9dd802eadad |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:7c763ccbcec74bc6b4f1c9dd802eadad2021-12-02T14:38:50ZInterethnic analyses of blood pressure loci in populations of East Asian and European descent10.1038/s41467-018-07345-02041-1723https://doaj.org/article/7c763ccbcec74bc6b4f1c9dd802eadad2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07345-0https://doaj.org/toc/2041-1723Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, the authors perform discovery GWAS for BP in East Asians and meta-analysis in East Asians and Europeans and report ancestry-specific BP SNPs and selection signals.Fumihiko TakeuchiMasato AkiyamaNana MatobaTomohiro KatsuyaMasahiro NakatochiYasuharu TabaraAkira NaritaWoei-Yuh SawSanghoon MoonCassandra N. SpracklenJin-Fang ChaiYoung-Jin KimLiang ZhangChaolong WangHuaixing LiHonglan LiJer-Yuarn WuRajkumar DorajooJovia L. NierenbergYa Xing WangJing HeDerrick A. BennettAtsushi TakahashiYukihide MomozawaMakoto HirataKoichi MatsudaHiromi RakugiEitaro NakashimaMasato IsonoMatsuyuki ShirotaAtsushi HozawaSahoko IchiharaTatsuaki MatsubaraKen YamamotoKatsuhiko KoharaMichiya IgaseSohee HanPenny Gordon-LarsenWei HuangNanette R. LeeLinda S. AdairMi Yeong HwangJuyoung LeeMiao Li CheeCharumathi SabanayagamWanting ZhaoJianjun LiuDermot F. ReillyLiang SunShaofeng HuoTodd L. EdwardsJirong LongLi-Ching ChangChien-Hsiun ChenJian-Min YuanWoon-Puay KohYechiel FriedlanderTanika N. KellyWen Bin WeiLiang XuHui CaiYong-Bing XiangKuang LinRobert ClarkeRobin G. WaltersIona Y. MillwoodLiming LiJohn C. ChambersJaspal S. KoonerPaul ElliottPim van der HarstThe International Genomics of Blood Pressure (iGEN-BP) ConsortiumZhengming ChenMakoto SasakiXiao-Ou ShuJost B. JonasJiang HeChew-Kiat HengYuan-Tsong ChenWei ZhengXu LinYik-Ying TeoE-Shyong TaiChing-Yu ChengTien Yin WongXueling SimKaren L. MohlkeMasayuki YamamotoBong-Jo KimTetsuro MikiToru NabikaMitsuhiro YokotaYoichiro KamataniMichiaki KuboNorihiro KatoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Fumihiko Takeuchi Masato Akiyama Nana Matoba Tomohiro Katsuya Masahiro Nakatochi Yasuharu Tabara Akira Narita Woei-Yuh Saw Sanghoon Moon Cassandra N. Spracklen Jin-Fang Chai Young-Jin Kim Liang Zhang Chaolong Wang Huaixing Li Honglan Li Jer-Yuarn Wu Rajkumar Dorajoo Jovia L. Nierenberg Ya Xing Wang Jing He Derrick A. Bennett Atsushi Takahashi Yukihide Momozawa Makoto Hirata Koichi Matsuda Hiromi Rakugi Eitaro Nakashima Masato Isono Matsuyuki Shirota Atsushi Hozawa Sahoko Ichihara Tatsuaki Matsubara Ken Yamamoto Katsuhiko Kohara Michiya Igase Sohee Han Penny Gordon-Larsen Wei Huang Nanette R. Lee Linda S. Adair Mi Yeong Hwang Juyoung Lee Miao Li Chee Charumathi Sabanayagam Wanting Zhao Jianjun Liu Dermot F. Reilly Liang Sun Shaofeng Huo Todd L. Edwards Jirong Long Li-Ching Chang Chien-Hsiun Chen Jian-Min Yuan Woon-Puay Koh Yechiel Friedlander Tanika N. Kelly Wen Bin Wei Liang Xu Hui Cai Yong-Bing Xiang Kuang Lin Robert Clarke Robin G. Walters Iona Y. Millwood Liming Li John C. Chambers Jaspal S. Kooner Paul Elliott Pim van der Harst The International Genomics of Blood Pressure (iGEN-BP) Consortium Zhengming Chen Makoto Sasaki Xiao-Ou Shu Jost B. Jonas Jiang He Chew-Kiat Heng Yuan-Tsong Chen Wei Zheng Xu Lin Yik-Ying Teo E-Shyong Tai Ching-Yu Cheng Tien Yin Wong Xueling Sim Karen L. Mohlke Masayuki Yamamoto Bong-Jo Kim Tetsuro Miki Toru Nabika Mitsuhiro Yokota Yoichiro Kamatani Michiaki Kubo Norihiro Kato Interethnic analyses of blood pressure loci in populations of East Asian and European descent |
| description |
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, the authors perform discovery GWAS for BP in East Asians and meta-analysis in East Asians and Europeans and report ancestry-specific BP SNPs and selection signals. |
| format |
article |
| author |
Fumihiko Takeuchi Masato Akiyama Nana Matoba Tomohiro Katsuya Masahiro Nakatochi Yasuharu Tabara Akira Narita Woei-Yuh Saw Sanghoon Moon Cassandra N. Spracklen Jin-Fang Chai Young-Jin Kim Liang Zhang Chaolong Wang Huaixing Li Honglan Li Jer-Yuarn Wu Rajkumar Dorajoo Jovia L. Nierenberg Ya Xing Wang Jing He Derrick A. Bennett Atsushi Takahashi Yukihide Momozawa Makoto Hirata Koichi Matsuda Hiromi Rakugi Eitaro Nakashima Masato Isono Matsuyuki Shirota Atsushi Hozawa Sahoko Ichihara Tatsuaki Matsubara Ken Yamamoto Katsuhiko Kohara Michiya Igase Sohee Han Penny Gordon-Larsen Wei Huang Nanette R. Lee Linda S. Adair Mi Yeong Hwang Juyoung Lee Miao Li Chee Charumathi Sabanayagam Wanting Zhao Jianjun Liu Dermot F. Reilly Liang Sun Shaofeng Huo Todd L. Edwards Jirong Long Li-Ching Chang Chien-Hsiun Chen Jian-Min Yuan Woon-Puay Koh Yechiel Friedlander Tanika N. Kelly Wen Bin Wei Liang Xu Hui Cai Yong-Bing Xiang Kuang Lin Robert Clarke Robin G. Walters Iona Y. Millwood Liming Li John C. Chambers Jaspal S. Kooner Paul Elliott Pim van der Harst The International Genomics of Blood Pressure (iGEN-BP) Consortium Zhengming Chen Makoto Sasaki Xiao-Ou Shu Jost B. Jonas Jiang He Chew-Kiat Heng Yuan-Tsong Chen Wei Zheng Xu Lin Yik-Ying Teo E-Shyong Tai Ching-Yu Cheng Tien Yin Wong Xueling Sim Karen L. Mohlke Masayuki Yamamoto Bong-Jo Kim Tetsuro Miki Toru Nabika Mitsuhiro Yokota Yoichiro Kamatani Michiaki Kubo Norihiro Kato |
| author_facet |
Fumihiko Takeuchi Masato Akiyama Nana Matoba Tomohiro Katsuya Masahiro Nakatochi Yasuharu Tabara Akira Narita Woei-Yuh Saw Sanghoon Moon Cassandra N. Spracklen Jin-Fang Chai Young-Jin Kim Liang Zhang Chaolong Wang Huaixing Li Honglan Li Jer-Yuarn Wu Rajkumar Dorajoo Jovia L. Nierenberg Ya Xing Wang Jing He Derrick A. Bennett Atsushi Takahashi Yukihide Momozawa Makoto Hirata Koichi Matsuda Hiromi Rakugi Eitaro Nakashima Masato Isono Matsuyuki Shirota Atsushi Hozawa Sahoko Ichihara Tatsuaki Matsubara Ken Yamamoto Katsuhiko Kohara Michiya Igase Sohee Han Penny Gordon-Larsen Wei Huang Nanette R. Lee Linda S. Adair Mi Yeong Hwang Juyoung Lee Miao Li Chee Charumathi Sabanayagam Wanting Zhao Jianjun Liu Dermot F. Reilly Liang Sun Shaofeng Huo Todd L. Edwards Jirong Long Li-Ching Chang Chien-Hsiun Chen Jian-Min Yuan Woon-Puay Koh Yechiel Friedlander Tanika N. Kelly Wen Bin Wei Liang Xu Hui Cai Yong-Bing Xiang Kuang Lin Robert Clarke Robin G. Walters Iona Y. Millwood Liming Li John C. Chambers Jaspal S. Kooner Paul Elliott Pim van der Harst The International Genomics of Blood Pressure (iGEN-BP) Consortium Zhengming Chen Makoto Sasaki Xiao-Ou Shu Jost B. Jonas Jiang He Chew-Kiat Heng Yuan-Tsong Chen Wei Zheng Xu Lin Yik-Ying Teo E-Shyong Tai Ching-Yu Cheng Tien Yin Wong Xueling Sim Karen L. Mohlke Masayuki Yamamoto Bong-Jo Kim Tetsuro Miki Toru Nabika Mitsuhiro Yokota Yoichiro Kamatani Michiaki Kubo Norihiro Kato |
| author_sort |
Fumihiko Takeuchi |
| title |
Interethnic analyses of blood pressure loci in populations of East Asian and European descent |
| title_short |
Interethnic analyses of blood pressure loci in populations of East Asian and European descent |
| title_full |
Interethnic analyses of blood pressure loci in populations of East Asian and European descent |
| title_fullStr |
Interethnic analyses of blood pressure loci in populations of East Asian and European descent |
| title_full_unstemmed |
Interethnic analyses of blood pressure loci in populations of East Asian and European descent |
| title_sort |
interethnic analyses of blood pressure loci in populations of east asian and european descent |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/7c763ccbcec74bc6b4f1c9dd802eadad |
| work_keys_str_mv |
AT fumihikotakeuchi interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT masatoakiyama interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT nanamatoba interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT tomohirokatsuya interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT masahironakatochi interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT yasuharutabara interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT akiranarita interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT woeiyuhsaw interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT sanghoonmoon interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT cassandranspracklen interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT jinfangchai interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT youngjinkim interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT liangzhang interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT chaolongwang interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT huaixingli interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT honglanli interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT jeryuarnwu interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT rajkumardorajoo interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT jovialnierenberg interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT yaxingwang interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT jinghe interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT derrickabennett interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT atsushitakahashi interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT yukihidemomozawa interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT makotohirata interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT koichimatsuda interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT hiromirakugi interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT eitaronakashima interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT masatoisono interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT matsuyukishirota interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT atsushihozawa interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT sahokoichihara interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT tatsuakimatsubara interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT kenyamamoto interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT katsuhikokohara interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT michiyaigase interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT soheehan interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT pennygordonlarsen interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT weihuang interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT nanetterlee interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT lindasadair interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT miyeonghwang interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT juyounglee interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT miaolichee interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT charumathisabanayagam interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT wantingzhao interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT jianjunliu interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT dermotfreilly interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT liangsun interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT shaofenghuo interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT toddledwards interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT jironglong interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT lichingchang interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT chienhsiunchen interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT jianminyuan interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT woonpuaykoh interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT yechielfriedlander interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT tanikankelly interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT wenbinwei interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT liangxu interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT huicai interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT yongbingxiang interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT kuanglin interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT robertclarke interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT robingwalters interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT ionaymillwood interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT limingli interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT johncchambers interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT jaspalskooner interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT paulelliott interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT pimvanderharst interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT theinternationalgenomicsofbloodpressureigenbpconsortium interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT zhengmingchen interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT makotosasaki interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT xiaooushu interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT jostbjonas interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT jianghe interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT chewkiatheng interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT yuantsongchen interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT weizheng interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT xulin interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT yikyingteo interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT eshyongtai interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT chingyucheng interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT tienyinwong interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT xuelingsim interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT karenlmohlke interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT masayukiyamamoto interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT bongjokim interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT tetsuromiki interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT torunabika interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT mitsuhiroyokota interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT yoichirokamatani interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT michiakikubo interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent AT norihirokato interethnicanalysesofbloodpressurelociinpopulationsofeastasianandeuropeandescent |
| _version_ |
1718390843747860480 |