Cell Systems Bioelectricity: How Different Intercellular Gap Junctions Could Regionalize a Multicellular Aggregate

Electric potential distributions can act as instructive pre-patterns for development, regeneration, and tumorigenesis in cell systems. The biophysical states influence transcription, proliferation, cell shape, migration, and differentiation through biochemical and biomechanical downstream transducti...

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Autores principales:	Alejandro Riol, Javier Cervera, Michael Levin, Salvador Mafe
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cell bioelectricity electric potential patterns ion channels intercellular gap junctions tumorigenesis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/7c76c4a1471f459ca93b032e1c261fa5
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spelling	oai:doaj.org-article:7c76c4a1471f459ca93b032e1c261fa52021-11-11T15:27:39ZCell Systems Bioelectricity: How Different Intercellular Gap Junctions Could Regionalize a Multicellular Aggregate10.3390/cancers132153002072-6694https://doaj.org/article/7c76c4a1471f459ca93b032e1c261fa52021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5300https://doaj.org/toc/2072-6694Electric potential distributions can act as instructive pre-patterns for development, regeneration, and tumorigenesis in cell systems. The biophysical states influence transcription, proliferation, cell shape, migration, and differentiation through biochemical and biomechanical downstream transduction processes. A major knowledge gap is the origin of spatial patterns in vivo, and their relationship to the ion channels and the electrical synapses known as gap junctions. Understanding this is critical for basic evolutionary developmental biology as well as for regenerative medicine. We computationally show that cells may express connexin proteins with different voltage-gated gap junction conductances as a way to maintain multicellular regions at distinct membrane potentials. We show that increasing the multicellular connectivity via enhanced junction function does not always contribute to the bioelectrical normalization of abnormally depolarized multicellular patches. From a purely electrical junction view, this result suggests that the reduction rather than the increase of specific connexin levels can also be a suitable bioelectrical approach in some cases and time stages. We offer a minimum model that incorporates effective conductances ultimately related to specific ion channel and junction proteins that are amenable to external regulation. We suggest that the bioelectrical patterns and their encoded instructive information can be externally modulated by acting on the mean fields of cell systems, a complementary approach to that of acting on the molecular characteristics of individual cells. We believe that despite the limitations of a biophysically focused model, our approach can offer useful qualitative insights into the collective dynamics of cell system bioelectricity.Alejandro RiolJavier CerveraMichael LevinSalvador MafeMDPI AGarticlecell bioelectricityelectric potential patternsion channelsintercellular gap junctionstumorigenesisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5300, p 5300 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cell bioelectricity electric potential patterns ion channels intercellular gap junctions tumorigenesis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	cell bioelectricity electric potential patterns ion channels intercellular gap junctions tumorigenesis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Alejandro Riol Javier Cervera Michael Levin Salvador Mafe Cell Systems Bioelectricity: How Different Intercellular Gap Junctions Could Regionalize a Multicellular Aggregate
description	Electric potential distributions can act as instructive pre-patterns for development, regeneration, and tumorigenesis in cell systems. The biophysical states influence transcription, proliferation, cell shape, migration, and differentiation through biochemical and biomechanical downstream transduction processes. A major knowledge gap is the origin of spatial patterns in vivo, and their relationship to the ion channels and the electrical synapses known as gap junctions. Understanding this is critical for basic evolutionary developmental biology as well as for regenerative medicine. We computationally show that cells may express connexin proteins with different voltage-gated gap junction conductances as a way to maintain multicellular regions at distinct membrane potentials. We show that increasing the multicellular connectivity via enhanced junction function does not always contribute to the bioelectrical normalization of abnormally depolarized multicellular patches. From a purely electrical junction view, this result suggests that the reduction rather than the increase of specific connexin levels can also be a suitable bioelectrical approach in some cases and time stages. We offer a minimum model that incorporates effective conductances ultimately related to specific ion channel and junction proteins that are amenable to external regulation. We suggest that the bioelectrical patterns and their encoded instructive information can be externally modulated by acting on the mean fields of cell systems, a complementary approach to that of acting on the molecular characteristics of individual cells. We believe that despite the limitations of a biophysically focused model, our approach can offer useful qualitative insights into the collective dynamics of cell system bioelectricity.
format	article
author	Alejandro Riol Javier Cervera Michael Levin Salvador Mafe
author_facet	Alejandro Riol Javier Cervera Michael Levin Salvador Mafe
author_sort	Alejandro Riol
title	Cell Systems Bioelectricity: How Different Intercellular Gap Junctions Could Regionalize a Multicellular Aggregate
title_short	Cell Systems Bioelectricity: How Different Intercellular Gap Junctions Could Regionalize a Multicellular Aggregate
title_full	Cell Systems Bioelectricity: How Different Intercellular Gap Junctions Could Regionalize a Multicellular Aggregate
title_fullStr	Cell Systems Bioelectricity: How Different Intercellular Gap Junctions Could Regionalize a Multicellular Aggregate
title_full_unstemmed	Cell Systems Bioelectricity: How Different Intercellular Gap Junctions Could Regionalize a Multicellular Aggregate
title_sort	cell systems bioelectricity: how different intercellular gap junctions could regionalize a multicellular aggregate
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7c76c4a1471f459ca93b032e1c261fa5
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Cell Systems Bioelectricity: How Different Intercellular Gap Junctions Could Regionalize a Multicellular Aggregate

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