Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo

Metabolites can distinguish pathogenic from healthy cells, but they are hard to couple to current photosensitizers without altering their biological activity. Here the authors design a new family of photosensitizers that retain metabolite function to target pathogenic cells and ablate them by photod...

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Autores principales:	Sam Benson, Fabio de Moliner, Antonio Fernandez, Erkin Kuru, Nicholas L. Asiimwe, Jun-Seok Lee, Lloyd Hamilton, Dirk Sieger, Isabel R. Bravo, Abigail M. Elliot, Yi Feng, Marc Vendrell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7c76d727336a4219a0b74bca92987546
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spelling	oai:doaj.org-article:7c76d727336a4219a0b74bca929875462021-12-02T13:39:46ZPhotoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo10.1038/s41467-021-22578-22041-1723https://doaj.org/article/7c76d727336a4219a0b74bca929875462021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22578-2https://doaj.org/toc/2041-1723Metabolites can distinguish pathogenic from healthy cells, but they are hard to couple to current photosensitizers without altering their biological activity. Here the authors design a new family of photosensitizers that retain metabolite function to target pathogenic cells and ablate them by photodynamic therapy.Sam BensonFabio de MolinerAntonio FernandezErkin KuruNicholas L. AsiimweJun-Seok LeeLloyd HamiltonDirk SiegerIsabel R. BravoAbigail M. ElliotYi FengMarc VendrellNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sam Benson Fabio de Moliner Antonio Fernandez Erkin Kuru Nicholas L. Asiimwe Jun-Seok Lee Lloyd Hamilton Dirk Sieger Isabel R. Bravo Abigail M. Elliot Yi Feng Marc Vendrell Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo
description	Metabolites can distinguish pathogenic from healthy cells, but they are hard to couple to current photosensitizers without altering their biological activity. Here the authors design a new family of photosensitizers that retain metabolite function to target pathogenic cells and ablate them by photodynamic therapy.
format	article
author	Sam Benson Fabio de Moliner Antonio Fernandez Erkin Kuru Nicholas L. Asiimwe Jun-Seok Lee Lloyd Hamilton Dirk Sieger Isabel R. Bravo Abigail M. Elliot Yi Feng Marc Vendrell
author_facet	Sam Benson Fabio de Moliner Antonio Fernandez Erkin Kuru Nicholas L. Asiimwe Jun-Seok Lee Lloyd Hamilton Dirk Sieger Isabel R. Bravo Abigail M. Elliot Yi Feng Marc Vendrell
author_sort	Sam Benson
title	Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo
title_short	Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo
title_full	Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo
title_fullStr	Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo
title_full_unstemmed	Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo
title_sort	photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7c76d727336a4219a0b74bca92987546
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Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo

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