Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer

Knatko et al. examined the importance of Nrf2 activity in the development of colorectal adenomas by performing genetic and pharmacological analyses. The authors found that Keap1 knockdown and Nrf2 activation impacted the metabolism of the non-tumoral colon, but did not affect colorectal adenoma form...

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Autores principales:	Elena V. Knatko, Cecilia Castro, Maureen Higgins, Ying Zhang, Tadashi Honda, Colin J. Henderson, C. Roland Wolf, Julian L. Griffin, Albena T. Dinkova-Kostova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7c780740b0f74743a3772c55d2dbaca7
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spelling	oai:doaj.org-article:7c780740b0f74743a3772c55d2dbaca72021-12-02T18:02:14ZNrf2 activation does not affect adenoma development in a mouse model of colorectal cancer10.1038/s42003-021-02552-w2399-3642https://doaj.org/article/7c780740b0f74743a3772c55d2dbaca72021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02552-whttps://doaj.org/toc/2399-3642Knatko et al. examined the importance of Nrf2 activity in the development of colorectal adenomas by performing genetic and pharmacological analyses. The authors found that Keap1 knockdown and Nrf2 activation impacted the metabolism of the non-tumoral colon, but did not affect colorectal adenoma formation in this model.Elena V. KnatkoCecilia CastroMaureen HigginsYing ZhangTadashi HondaColin J. HendersonC. Roland WolfJulian L. GriffinAlbena T. Dinkova-KostovaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Elena V. Knatko Cecilia Castro Maureen Higgins Ying Zhang Tadashi Honda Colin J. Henderson C. Roland Wolf Julian L. Griffin Albena T. Dinkova-Kostova Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer
description	Knatko et al. examined the importance of Nrf2 activity in the development of colorectal adenomas by performing genetic and pharmacological analyses. The authors found that Keap1 knockdown and Nrf2 activation impacted the metabolism of the non-tumoral colon, but did not affect colorectal adenoma formation in this model.
format	article
author	Elena V. Knatko Cecilia Castro Maureen Higgins Ying Zhang Tadashi Honda Colin J. Henderson C. Roland Wolf Julian L. Griffin Albena T. Dinkova-Kostova
author_facet	Elena V. Knatko Cecilia Castro Maureen Higgins Ying Zhang Tadashi Honda Colin J. Henderson C. Roland Wolf Julian L. Griffin Albena T. Dinkova-Kostova
author_sort	Elena V. Knatko
title	Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer
title_short	Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer
title_full	Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer
title_fullStr	Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer
title_full_unstemmed	Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer
title_sort	nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7c780740b0f74743a3772c55d2dbaca7
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Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer

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