Cesarean section delivery is a risk factor of autism-related behaviors in mice

Abstract Cesarean section (C/S) is one way of delivering babies, and is chosen when mothers or babies are facing problems or life-threatening conditions during pregnancy. Many meta-analyses have suggested an etiological relationship between C/S delivery and autism spectrum disorders (ASDs). However,...

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Autores principales:	Masatoshi Nagano, Fumihito Saitow, Shinpei Higo, Makoto Uzuki, Yasunori Mikahara, Toshio Akimoto, Hitoshi Ozawa, Katsuhiko Nishimori, Hidenori Suzuki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7c7854fce09a4fc88b38632b81184079
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spelling	oai:doaj.org-article:7c7854fce09a4fc88b38632b811840792021-12-02T17:15:33ZCesarean section delivery is a risk factor of autism-related behaviors in mice10.1038/s41598-021-88437-82045-2322https://doaj.org/article/7c7854fce09a4fc88b38632b811840792021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88437-8https://doaj.org/toc/2045-2322Abstract Cesarean section (C/S) is one way of delivering babies, and is chosen when mothers or babies are facing problems or life-threatening conditions during pregnancy. Many meta-analyses have suggested an etiological relationship between C/S delivery and autism spectrum disorders (ASDs). However, as a risk factor for ASDs, C/S delivery has not yet been well studied. Because C/S deliveries have been increasing, it is very important to investigate the causal association between C/S and ASDs. Here, using three approaches, we showed experimentally that C/S delivery induced ASD-like traits in offspring mice, and that some of these changes were ameliorated by one-time oxytocin (OXT) treatment. Treatment with OXT receptor antagonists before natural delivery also induced ASD-related behaviors. Moreover, wild-type mice born to OXT-KO dams showed similar changes. Thus, insufficient OXT exposure from dams to offspring during delivery may be a trigger for ASD-related behaviors.Masatoshi NaganoFumihito SaitowShinpei HigoMakoto UzukiYasunori MikaharaToshio AkimotoHitoshi OzawaKatsuhiko NishimoriHidenori SuzukiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masatoshi Nagano Fumihito Saitow Shinpei Higo Makoto Uzuki Yasunori Mikahara Toshio Akimoto Hitoshi Ozawa Katsuhiko Nishimori Hidenori Suzuki Cesarean section delivery is a risk factor of autism-related behaviors in mice
description	Abstract Cesarean section (C/S) is one way of delivering babies, and is chosen when mothers or babies are facing problems or life-threatening conditions during pregnancy. Many meta-analyses have suggested an etiological relationship between C/S delivery and autism spectrum disorders (ASDs). However, as a risk factor for ASDs, C/S delivery has not yet been well studied. Because C/S deliveries have been increasing, it is very important to investigate the causal association between C/S and ASDs. Here, using three approaches, we showed experimentally that C/S delivery induced ASD-like traits in offspring mice, and that some of these changes were ameliorated by one-time oxytocin (OXT) treatment. Treatment with OXT receptor antagonists before natural delivery also induced ASD-related behaviors. Moreover, wild-type mice born to OXT-KO dams showed similar changes. Thus, insufficient OXT exposure from dams to offspring during delivery may be a trigger for ASD-related behaviors.
format	article
author	Masatoshi Nagano Fumihito Saitow Shinpei Higo Makoto Uzuki Yasunori Mikahara Toshio Akimoto Hitoshi Ozawa Katsuhiko Nishimori Hidenori Suzuki
author_facet	Masatoshi Nagano Fumihito Saitow Shinpei Higo Makoto Uzuki Yasunori Mikahara Toshio Akimoto Hitoshi Ozawa Katsuhiko Nishimori Hidenori Suzuki
author_sort	Masatoshi Nagano
title	Cesarean section delivery is a risk factor of autism-related behaviors in mice
title_short	Cesarean section delivery is a risk factor of autism-related behaviors in mice
title_full	Cesarean section delivery is a risk factor of autism-related behaviors in mice
title_fullStr	Cesarean section delivery is a risk factor of autism-related behaviors in mice
title_full_unstemmed	Cesarean section delivery is a risk factor of autism-related behaviors in mice
title_sort	cesarean section delivery is a risk factor of autism-related behaviors in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7c7854fce09a4fc88b38632b81184079
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Cesarean section delivery is a risk factor of autism-related behaviors in mice

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