The Effect of shape on Cellular Uptake of Gold Nanoparticles in the forms of Stars, Rods, and Triangles

Abstract Gold nanomaterials have attracted considerable interest as vehicles for intracellular drug delivery. In our study, we synthesized three different shapes of methylpolyethylene glycol coated-anisotropic gold nanoparticles: stars, rods, and triangles. The cellular internalization of these nano...

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Autores principales:	Xueping Xie, Jinfeng Liao, Xiaoru Shao, Qianshun Li, Yunfeng Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7c793b53c879492b9a8ce9ad17f490af
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spelling	oai:doaj.org-article:7c793b53c879492b9a8ce9ad17f490af2021-12-02T11:52:42ZThe Effect of shape on Cellular Uptake of Gold Nanoparticles in the forms of Stars, Rods, and Triangles10.1038/s41598-017-04229-z2045-2322https://doaj.org/article/7c793b53c879492b9a8ce9ad17f490af2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04229-zhttps://doaj.org/toc/2045-2322Abstract Gold nanomaterials have attracted considerable interest as vehicles for intracellular drug delivery. In our study, we synthesized three different shapes of methylpolyethylene glycol coated-anisotropic gold nanoparticles: stars, rods, and triangles. The cellular internalization of these nanoparticles by RAW264.7 cells was analyzed, providing a parametric evaluation of the effect of shape. The efficiency of cellular uptake of the gold nanoparticles was found to rank in the following order from lowest to highest: stars, rods, and triangles. The possible mechanisms of cellular uptake for the three types of gold nanoparticles were examined, and it was found that different shapes tended to use the various endocytosis pathways in different proportions. Our study, which has demonstrated that shape can modulate the uptake of nanoparticles into RAW264.7 cells and that triangles were the shape with the most efficient cellular uptake, provides useful guidance toward the design of nanomaterials for drug delivery.Xueping XieJinfeng LiaoXiaoru ShaoQianshun LiYunfeng LinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xueping Xie Jinfeng Liao Xiaoru Shao Qianshun Li Yunfeng Lin The Effect of shape on Cellular Uptake of Gold Nanoparticles in the forms of Stars, Rods, and Triangles
description	Abstract Gold nanomaterials have attracted considerable interest as vehicles for intracellular drug delivery. In our study, we synthesized three different shapes of methylpolyethylene glycol coated-anisotropic gold nanoparticles: stars, rods, and triangles. The cellular internalization of these nanoparticles by RAW264.7 cells was analyzed, providing a parametric evaluation of the effect of shape. The efficiency of cellular uptake of the gold nanoparticles was found to rank in the following order from lowest to highest: stars, rods, and triangles. The possible mechanisms of cellular uptake for the three types of gold nanoparticles were examined, and it was found that different shapes tended to use the various endocytosis pathways in different proportions. Our study, which has demonstrated that shape can modulate the uptake of nanoparticles into RAW264.7 cells and that triangles were the shape with the most efficient cellular uptake, provides useful guidance toward the design of nanomaterials for drug delivery.
format	article
author	Xueping Xie Jinfeng Liao Xiaoru Shao Qianshun Li Yunfeng Lin
author_facet	Xueping Xie Jinfeng Liao Xiaoru Shao Qianshun Li Yunfeng Lin
author_sort	Xueping Xie
title	The Effect of shape on Cellular Uptake of Gold Nanoparticles in the forms of Stars, Rods, and Triangles
title_short	The Effect of shape on Cellular Uptake of Gold Nanoparticles in the forms of Stars, Rods, and Triangles
title_full	The Effect of shape on Cellular Uptake of Gold Nanoparticles in the forms of Stars, Rods, and Triangles
title_fullStr	The Effect of shape on Cellular Uptake of Gold Nanoparticles in the forms of Stars, Rods, and Triangles
title_full_unstemmed	The Effect of shape on Cellular Uptake of Gold Nanoparticles in the forms of Stars, Rods, and Triangles
title_sort	effect of shape on cellular uptake of gold nanoparticles in the forms of stars, rods, and triangles
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7c793b53c879492b9a8ce9ad17f490af
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The Effect of shape on Cellular Uptake of Gold Nanoparticles in the forms of Stars, Rods, and Triangles

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