Loss of β-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice

Understanding the mechanisms causing cardiac fibrosis is key to prevention and therapy development of many heart diseases. Here, the authors show that Wnt/β-catenin signaling in resident cardiac fibroblasts is required for deposition of fibrotic extracellular matrix and the regulation of cardiomyocy...

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Autores principales:	Fu-Li Xiang, Ming Fang, Katherine E. Yutzey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7c7af10691964b558bca3ee7f73cc0f5
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spelling	oai:doaj.org-article:7c7af10691964b558bca3ee7f73cc0f52021-12-02T14:42:43ZLoss of β-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice10.1038/s41467-017-00840-w2041-1723https://doaj.org/article/7c7af10691964b558bca3ee7f73cc0f52017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00840-whttps://doaj.org/toc/2041-1723Understanding the mechanisms causing cardiac fibrosis is key to prevention and therapy development of many heart diseases. Here, the authors show that Wnt/β-catenin signaling in resident cardiac fibroblasts is required for deposition of fibrotic extracellular matrix and the regulation of cardiomyocyte hypertrophy in a mouse model of heart fibrosis.Fu-Li XiangMing FangKatherine E. YutzeyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fu-Li Xiang Ming Fang Katherine E. Yutzey Loss of β-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice
description	Understanding the mechanisms causing cardiac fibrosis is key to prevention and therapy development of many heart diseases. Here, the authors show that Wnt/β-catenin signaling in resident cardiac fibroblasts is required for deposition of fibrotic extracellular matrix and the regulation of cardiomyocyte hypertrophy in a mouse model of heart fibrosis.
format	article
author	Fu-Li Xiang Ming Fang Katherine E. Yutzey
author_facet	Fu-Li Xiang Ming Fang Katherine E. Yutzey
author_sort	Fu-Li Xiang
title	Loss of β-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice
title_short	Loss of β-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice
title_full	Loss of β-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice
title_fullStr	Loss of β-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice
title_full_unstemmed	Loss of β-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice
title_sort	loss of β-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7c7af10691964b558bca3ee7f73cc0f5
work_keys_str_mv	AT fulixiang lossofbcatenininresidentcardiacfibroblastsattenuatesfibrosisinducedbypressureoverloadinmice AT mingfang lossofbcatenininresidentcardiacfibroblastsattenuatesfibrosisinducedbypressureoverloadinmice AT katherineeyutzey lossofbcatenininresidentcardiacfibroblastsattenuatesfibrosisinducedbypressureoverloadinmice
_version_	1718389637719785472

Loss of β-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice

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