Small cell lung cancer transformation during antitumor therapies: A systematic review
Lung cancer is the most common cause of cancer-related death. Non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) are the two major histological categories of lung cancers. Drug resistance is a great challenge for cancer treatment, and histological transformation from NSCLC to SCLC...
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De Gruyter
2021
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oai:doaj.org-article:7c7b5d0ce5b64da0a7fff78444a2a7a82021-12-05T14:10:55ZSmall cell lung cancer transformation during antitumor therapies: A systematic review2391-546310.1515/med-2021-0321https://doaj.org/article/7c7b5d0ce5b64da0a7fff78444a2a7a82021-08-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0321https://doaj.org/toc/2391-5463Lung cancer is the most common cause of cancer-related death. Non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) are the two major histological categories of lung cancers. Drug resistance is a great challenge for cancer treatment, and histological transformation from NSCLC to SCLC is one of the mechanisms underlying drug resistance in NSCLC patients. SCLC-transformed patients show combined characteristics of NSCLC and SCLC; however, they lack timely diagnoses and effective treatment strategies. Thus, we reviewed the clinical characteristics of SCLC transformation patients with a literature search to enhance clinical consciousness, diagnosis, and personalized treatment for patients with it.Chai XingZhang XinruLi WenqianChai JinDe GruyterarticletransformationnsclcsclcMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 1160-1167 (2021) |
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transformation nsclc sclc Medicine R Chai Xing Zhang Xinru Li Wenqian Chai Jin Small cell lung cancer transformation during antitumor therapies: A systematic review |
description |
Lung cancer is the most common cause of cancer-related death. Non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) are the two major histological categories of lung cancers. Drug resistance is a great challenge for cancer treatment, and histological transformation from NSCLC to SCLC is one of the mechanisms underlying drug resistance in NSCLC patients. SCLC-transformed patients show combined characteristics of NSCLC and SCLC; however, they lack timely diagnoses and effective treatment strategies. Thus, we reviewed the clinical characteristics of SCLC transformation patients with a literature search to enhance clinical consciousness, diagnosis, and personalized treatment for patients with it. |
format |
article |
author |
Chai Xing Zhang Xinru Li Wenqian Chai Jin |
author_facet |
Chai Xing Zhang Xinru Li Wenqian Chai Jin |
author_sort |
Chai Xing |
title |
Small cell lung cancer transformation during antitumor therapies: A systematic review |
title_short |
Small cell lung cancer transformation during antitumor therapies: A systematic review |
title_full |
Small cell lung cancer transformation during antitumor therapies: A systematic review |
title_fullStr |
Small cell lung cancer transformation during antitumor therapies: A systematic review |
title_full_unstemmed |
Small cell lung cancer transformation during antitumor therapies: A systematic review |
title_sort |
small cell lung cancer transformation during antitumor therapies: a systematic review |
publisher |
De Gruyter |
publishDate |
2021 |
url |
https://doaj.org/article/7c7b5d0ce5b64da0a7fff78444a2a7a8 |
work_keys_str_mv |
AT chaixing smallcelllungcancertransformationduringantitumortherapiesasystematicreview AT zhangxinru smallcelllungcancertransformationduringantitumortherapiesasystematicreview AT liwenqian smallcelllungcancertransformationduringantitumortherapiesasystematicreview AT chaijin smallcelllungcancertransformationduringantitumortherapiesasystematicreview |
_version_ |
1718371613323296768 |