Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans.
The regulation of energy balance involves an intricate interplay between neural mechanisms that respond to internal and external cues of energy demand and food availability. Compelling data have implicated the neurotransmitter dopamine as an important part of body weight regulation. However, the pre...
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2014
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oai:doaj.org-article:7c829fa902f843f0aff66846c60ce7d22021-11-18T08:36:32ZDopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans.1932-620310.1371/journal.pone.0085874https://doaj.org/article/7c829fa902f843f0aff66846c60ce7d22014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24465759/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The regulation of energy balance involves an intricate interplay between neural mechanisms that respond to internal and external cues of energy demand and food availability. Compelling data have implicated the neurotransmitter dopamine as an important part of body weight regulation. However, the precise mechanisms through which dopamine regulates energy homeostasis remain poorly understood. Here, we investigate mechanisms through which dopamine modulates energy storage. We showed that dopamine signaling regulates fat reservoirs in Caenorhabditis elegans. We found that the fat reducing effects of dopamine were dependent on dopaminergic receptors and a set of fat oxidation enzymes. Our findings reveal an ancient role for dopaminergic regulation of fat and suggest that dopamine signaling elicits this outcome through cascades that ultimately mobilize peripheral fat depots.Alexandre Guimarães de Almeida BarrosJessika Cristina BridiBruno Rezende de SouzaCélio de Castro JúniorKaren Cecília de Lima TorresLeandro MalardAdo JorioDébora Marques de MirandaKaveh AshrafiMarco Aurélio Romano-SilvaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e85874 (2014) |
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Medicine R Science Q Alexandre Guimarães de Almeida Barros Jessika Cristina Bridi Bruno Rezende de Souza Célio de Castro Júnior Karen Cecília de Lima Torres Leandro Malard Ado Jorio Débora Marques de Miranda Kaveh Ashrafi Marco Aurélio Romano-Silva Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans. |
description |
The regulation of energy balance involves an intricate interplay between neural mechanisms that respond to internal and external cues of energy demand and food availability. Compelling data have implicated the neurotransmitter dopamine as an important part of body weight regulation. However, the precise mechanisms through which dopamine regulates energy homeostasis remain poorly understood. Here, we investigate mechanisms through which dopamine modulates energy storage. We showed that dopamine signaling regulates fat reservoirs in Caenorhabditis elegans. We found that the fat reducing effects of dopamine were dependent on dopaminergic receptors and a set of fat oxidation enzymes. Our findings reveal an ancient role for dopaminergic regulation of fat and suggest that dopamine signaling elicits this outcome through cascades that ultimately mobilize peripheral fat depots. |
format |
article |
author |
Alexandre Guimarães de Almeida Barros Jessika Cristina Bridi Bruno Rezende de Souza Célio de Castro Júnior Karen Cecília de Lima Torres Leandro Malard Ado Jorio Débora Marques de Miranda Kaveh Ashrafi Marco Aurélio Romano-Silva |
author_facet |
Alexandre Guimarães de Almeida Barros Jessika Cristina Bridi Bruno Rezende de Souza Célio de Castro Júnior Karen Cecília de Lima Torres Leandro Malard Ado Jorio Débora Marques de Miranda Kaveh Ashrafi Marco Aurélio Romano-Silva |
author_sort |
Alexandre Guimarães de Almeida Barros |
title |
Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans. |
title_short |
Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans. |
title_full |
Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans. |
title_fullStr |
Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans. |
title_full_unstemmed |
Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans. |
title_sort |
dopamine signaling regulates fat content through β-oxidation in caenorhabditis elegans. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doaj.org/article/7c829fa902f843f0aff66846c60ce7d2 |
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