Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans.

The regulation of energy balance involves an intricate interplay between neural mechanisms that respond to internal and external cues of energy demand and food availability. Compelling data have implicated the neurotransmitter dopamine as an important part of body weight regulation. However, the pre...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Alexandre Guimarães de Almeida Barros, Jessika Cristina Bridi, Bruno Rezende de Souza, Célio de Castro Júnior, Karen Cecília de Lima Torres, Leandro Malard, Ado Jorio, Débora Marques de Miranda, Kaveh Ashrafi, Marco Aurélio Romano-Silva
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
R
Q
Acceso en línea:https://doaj.org/article/7c829fa902f843f0aff66846c60ce7d2
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:7c829fa902f843f0aff66846c60ce7d2
record_format dspace
spelling oai:doaj.org-article:7c829fa902f843f0aff66846c60ce7d22021-11-18T08:36:32ZDopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans.1932-620310.1371/journal.pone.0085874https://doaj.org/article/7c829fa902f843f0aff66846c60ce7d22014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24465759/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The regulation of energy balance involves an intricate interplay between neural mechanisms that respond to internal and external cues of energy demand and food availability. Compelling data have implicated the neurotransmitter dopamine as an important part of body weight regulation. However, the precise mechanisms through which dopamine regulates energy homeostasis remain poorly understood. Here, we investigate mechanisms through which dopamine modulates energy storage. We showed that dopamine signaling regulates fat reservoirs in Caenorhabditis elegans. We found that the fat reducing effects of dopamine were dependent on dopaminergic receptors and a set of fat oxidation enzymes. Our findings reveal an ancient role for dopaminergic regulation of fat and suggest that dopamine signaling elicits this outcome through cascades that ultimately mobilize peripheral fat depots.Alexandre Guimarães de Almeida BarrosJessika Cristina BridiBruno Rezende de SouzaCélio de Castro JúniorKaren Cecília de Lima TorresLeandro MalardAdo JorioDébora Marques de MirandaKaveh AshrafiMarco Aurélio Romano-SilvaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e85874 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Alexandre Guimarães de Almeida Barros
Jessika Cristina Bridi
Bruno Rezende de Souza
Célio de Castro Júnior
Karen Cecília de Lima Torres
Leandro Malard
Ado Jorio
Débora Marques de Miranda
Kaveh Ashrafi
Marco Aurélio Romano-Silva
Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans.
description The regulation of energy balance involves an intricate interplay between neural mechanisms that respond to internal and external cues of energy demand and food availability. Compelling data have implicated the neurotransmitter dopamine as an important part of body weight regulation. However, the precise mechanisms through which dopamine regulates energy homeostasis remain poorly understood. Here, we investigate mechanisms through which dopamine modulates energy storage. We showed that dopamine signaling regulates fat reservoirs in Caenorhabditis elegans. We found that the fat reducing effects of dopamine were dependent on dopaminergic receptors and a set of fat oxidation enzymes. Our findings reveal an ancient role for dopaminergic regulation of fat and suggest that dopamine signaling elicits this outcome through cascades that ultimately mobilize peripheral fat depots.
format article
author Alexandre Guimarães de Almeida Barros
Jessika Cristina Bridi
Bruno Rezende de Souza
Célio de Castro Júnior
Karen Cecília de Lima Torres
Leandro Malard
Ado Jorio
Débora Marques de Miranda
Kaveh Ashrafi
Marco Aurélio Romano-Silva
author_facet Alexandre Guimarães de Almeida Barros
Jessika Cristina Bridi
Bruno Rezende de Souza
Célio de Castro Júnior
Karen Cecília de Lima Torres
Leandro Malard
Ado Jorio
Débora Marques de Miranda
Kaveh Ashrafi
Marco Aurélio Romano-Silva
author_sort Alexandre Guimarães de Almeida Barros
title Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans.
title_short Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans.
title_full Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans.
title_fullStr Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans.
title_full_unstemmed Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans.
title_sort dopamine signaling regulates fat content through β-oxidation in caenorhabditis elegans.
publisher Public Library of Science (PLoS)
publishDate 2014
url https://doaj.org/article/7c829fa902f843f0aff66846c60ce7d2
work_keys_str_mv AT alexandreguimaraesdealmeidabarros dopaminesignalingregulatesfatcontentthroughboxidationincaenorhabditiselegans
AT jessikacristinabridi dopaminesignalingregulatesfatcontentthroughboxidationincaenorhabditiselegans
AT brunorezendedesouza dopaminesignalingregulatesfatcontentthroughboxidationincaenorhabditiselegans
AT celiodecastrojunior dopaminesignalingregulatesfatcontentthroughboxidationincaenorhabditiselegans
AT karenceciliadelimatorres dopaminesignalingregulatesfatcontentthroughboxidationincaenorhabditiselegans
AT leandromalard dopaminesignalingregulatesfatcontentthroughboxidationincaenorhabditiselegans
AT adojorio dopaminesignalingregulatesfatcontentthroughboxidationincaenorhabditiselegans
AT deboramarquesdemiranda dopaminesignalingregulatesfatcontentthroughboxidationincaenorhabditiselegans
AT kavehashrafi dopaminesignalingregulatesfatcontentthroughboxidationincaenorhabditiselegans
AT marcoaurelioromanosilva dopaminesignalingregulatesfatcontentthroughboxidationincaenorhabditiselegans
_version_ 1718421571259858944