Correlation between brain function and ADHD symptom changes in children with ADHD following a few-foods diet: an open-label intervention trial

Abstract Research into the effect of nutrition on attention-deficit hyperactivity disorder (ADHD) in children has shown that the few-foods diet (FFD) substantially decreases ADHD symptoms in 60% of children. However, the underlying mechanism is unknown. In this open-label nutritional intervention st...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Saartje Hontelez, Tim Stobernack, Lidy M. Pelsser, Peter van Baarlen, Klaas Frankena, Martine M. Groefsema, Michiel Kleerebezem, Rob Rodrigues Pereira, Elbrich M. Postma, Paul A. M. Smeets, Marion A. Stopyra, Marcel P. Zwiers, Esther Aarts
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7c84c9e5de5347cbb200d55355c4de10
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7c84c9e5de5347cbb200d55355c4de10
record_format	dspace
spelling	oai:doaj.org-article:7c84c9e5de5347cbb200d55355c4de102021-11-14T12:21:42ZCorrelation between brain function and ADHD symptom changes in children with ADHD following a few-foods diet: an open-label intervention trial10.1038/s41598-021-01684-72045-2322https://doaj.org/article/7c84c9e5de5347cbb200d55355c4de102021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01684-7https://doaj.org/toc/2045-2322Abstract Research into the effect of nutrition on attention-deficit hyperactivity disorder (ADHD) in children has shown that the few-foods diet (FFD) substantially decreases ADHD symptoms in 60% of children. However, the underlying mechanism is unknown. In this open-label nutritional intervention study we investigated whether behavioural changes after following an FFD are associated with changes in brain function during inhibitory control in 79 boys with ADHD, aged 8–10 years. Parents completed the ADHD Rating Scale before (t1) and after the FFD (t2). Functional magnetic resonance imaging (fMRI) scans were acquired during a stop-signal task at t1 and t2, and initial subject-level analyses were done blinded for ARS scores. Fifty (63%) participants were diet responders, showing a decrease of ADHD symptoms of at least 40%. Fifty-three children had fMRI scans of sufficient quality for further analysis. Region-of-interest analyses demonstrated that brain activation in regions implicated in the stop-signal task was not associated with ADHD symptom change. However, whole-brain analyses revealed a correlation between ADHD symptom decrease and increased precuneus activation (pFWE(cluster) = 0.015 for StopSuccess > Go trials and pFWE(cluster) < 0.001 for StopSuccess > StopFail trials). These results provide evidence for a neurocognitive mechanism underlying the efficacy of a few-foods diet in children with ADHD.Saartje HontelezTim StobernackLidy M. PelsserPeter van BaarlenKlaas FrankenaMartine M. GroefsemaMichiel KleerebezemRob Rodrigues PereiraElbrich M. PostmaPaul A. M. SmeetsMarion A. StopyraMarcel P. ZwiersEsther AartsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Saartje Hontelez Tim Stobernack Lidy M. Pelsser Peter van Baarlen Klaas Frankena Martine M. Groefsema Michiel Kleerebezem Rob Rodrigues Pereira Elbrich M. Postma Paul A. M. Smeets Marion A. Stopyra Marcel P. Zwiers Esther Aarts Correlation between brain function and ADHD symptom changes in children with ADHD following a few-foods diet: an open-label intervention trial
description	Abstract Research into the effect of nutrition on attention-deficit hyperactivity disorder (ADHD) in children has shown that the few-foods diet (FFD) substantially decreases ADHD symptoms in 60% of children. However, the underlying mechanism is unknown. In this open-label nutritional intervention study we investigated whether behavioural changes after following an FFD are associated with changes in brain function during inhibitory control in 79 boys with ADHD, aged 8–10 years. Parents completed the ADHD Rating Scale before (t1) and after the FFD (t2). Functional magnetic resonance imaging (fMRI) scans were acquired during a stop-signal task at t1 and t2, and initial subject-level analyses were done blinded for ARS scores. Fifty (63%) participants were diet responders, showing a decrease of ADHD symptoms of at least 40%. Fifty-three children had fMRI scans of sufficient quality for further analysis. Region-of-interest analyses demonstrated that brain activation in regions implicated in the stop-signal task was not associated with ADHD symptom change. However, whole-brain analyses revealed a correlation between ADHD symptom decrease and increased precuneus activation (pFWE(cluster) = 0.015 for StopSuccess > Go trials and pFWE(cluster) < 0.001 for StopSuccess > StopFail trials). These results provide evidence for a neurocognitive mechanism underlying the efficacy of a few-foods diet in children with ADHD.
format	article
author	Saartje Hontelez Tim Stobernack Lidy M. Pelsser Peter van Baarlen Klaas Frankena Martine M. Groefsema Michiel Kleerebezem Rob Rodrigues Pereira Elbrich M. Postma Paul A. M. Smeets Marion A. Stopyra Marcel P. Zwiers Esther Aarts
author_facet	Saartje Hontelez Tim Stobernack Lidy M. Pelsser Peter van Baarlen Klaas Frankena Martine M. Groefsema Michiel Kleerebezem Rob Rodrigues Pereira Elbrich M. Postma Paul A. M. Smeets Marion A. Stopyra Marcel P. Zwiers Esther Aarts
author_sort	Saartje Hontelez
title	Correlation between brain function and ADHD symptom changes in children with ADHD following a few-foods diet: an open-label intervention trial
title_short	Correlation between brain function and ADHD symptom changes in children with ADHD following a few-foods diet: an open-label intervention trial
title_full	Correlation between brain function and ADHD symptom changes in children with ADHD following a few-foods diet: an open-label intervention trial
title_fullStr	Correlation between brain function and ADHD symptom changes in children with ADHD following a few-foods diet: an open-label intervention trial
title_full_unstemmed	Correlation between brain function and ADHD symptom changes in children with ADHD following a few-foods diet: an open-label intervention trial
title_sort	correlation between brain function and adhd symptom changes in children with adhd following a few-foods diet: an open-label intervention trial
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7c84c9e5de5347cbb200d55355c4de10
work_keys_str_mv	AT saartjehontelez correlationbetweenbrainfunctionandadhdsymptomchangesinchildrenwithadhdfollowingafewfoodsdietanopenlabelinterventiontrial AT timstobernack correlationbetweenbrainfunctionandadhdsymptomchangesinchildrenwithadhdfollowingafewfoodsdietanopenlabelinterventiontrial AT lidympelsser correlationbetweenbrainfunctionandadhdsymptomchangesinchildrenwithadhdfollowingafewfoodsdietanopenlabelinterventiontrial AT petervanbaarlen correlationbetweenbrainfunctionandadhdsymptomchangesinchildrenwithadhdfollowingafewfoodsdietanopenlabelinterventiontrial AT klaasfrankena correlationbetweenbrainfunctionandadhdsymptomchangesinchildrenwithadhdfollowingafewfoodsdietanopenlabelinterventiontrial AT martinemgroefsema correlationbetweenbrainfunctionandadhdsymptomchangesinchildrenwithadhdfollowingafewfoodsdietanopenlabelinterventiontrial AT michielkleerebezem correlationbetweenbrainfunctionandadhdsymptomchangesinchildrenwithadhdfollowingafewfoodsdietanopenlabelinterventiontrial AT robrodriguespereira correlationbetweenbrainfunctionandadhdsymptomchangesinchildrenwithadhdfollowingafewfoodsdietanopenlabelinterventiontrial AT elbrichmpostma correlationbetweenbrainfunctionandadhdsymptomchangesinchildrenwithadhdfollowingafewfoodsdietanopenlabelinterventiontrial AT paulamsmeets correlationbetweenbrainfunctionandadhdsymptomchangesinchildrenwithadhdfollowingafewfoodsdietanopenlabelinterventiontrial AT marionastopyra correlationbetweenbrainfunctionandadhdsymptomchangesinchildrenwithadhdfollowingafewfoodsdietanopenlabelinterventiontrial AT marcelpzwiers correlationbetweenbrainfunctionandadhdsymptomchangesinchildrenwithadhdfollowingafewfoodsdietanopenlabelinterventiontrial AT estheraarts correlationbetweenbrainfunctionandadhdsymptomchangesinchildrenwithadhdfollowingafewfoodsdietanopenlabelinterventiontrial
_version_	1718429236845346816

Correlation between brain function and ADHD symptom changes in children with ADHD following a few-foods diet: an open-label intervention trial

Ejemplares similares