TAF1 plays a critical role in AML1-ETO driven leukemogenesis

AML1-ETO is a fusion protein in which acetylation of lysine-43 is critical to leukemogenesis. Here, they show that TAF1 is required for AML1-ETO mediated gene expression such that it binds to acetylated AML1-ETO to facilitate the association of AML1-ETO with chromatin, and consequently, promotes leu...

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Autores principales:	Ye Xu, Na Man, Daniel Karl, Concepcion Martinez, Fan Liu, Jun Sun, Camilo Jose Martinez, Gloria Mas Martin, Felipe Beckedorff, Fan Lai, Jingyin Yue, Alejandro Roisman, Sarah Greenblatt, Stephanie Duffort, Lan Wang, Xiaojian Sun, Maria Figueroa, Ramin Shiekhattar, Stephen Nimer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7c876bc2dac14cc194b471dadcb6299e
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spelling	oai:doaj.org-article:7c876bc2dac14cc194b471dadcb6299e2021-12-02T17:32:56ZTAF1 plays a critical role in AML1-ETO driven leukemogenesis10.1038/s41467-019-12735-z2041-1723https://doaj.org/article/7c876bc2dac14cc194b471dadcb6299e2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12735-zhttps://doaj.org/toc/2041-1723AML1-ETO is a fusion protein in which acetylation of lysine-43 is critical to leukemogenesis. Here, they show that TAF1 is required for AML1-ETO mediated gene expression such that it binds to acetylated AML1-ETO to facilitate the association of AML1-ETO with chromatin, and consequently, promotes leukemic self-renewal.Ye XuNa ManDaniel KarlConcepcion MartinezFan LiuJun SunCamilo Jose MartinezGloria Mas MartinFelipe BeckedorffFan LaiJingyin YueAlejandro RoismanSarah GreenblattStephanie DuffortLan WangXiaojian SunMaria FigueroaRamin ShiekhattarStephen NimerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ye Xu Na Man Daniel Karl Concepcion Martinez Fan Liu Jun Sun Camilo Jose Martinez Gloria Mas Martin Felipe Beckedorff Fan Lai Jingyin Yue Alejandro Roisman Sarah Greenblatt Stephanie Duffort Lan Wang Xiaojian Sun Maria Figueroa Ramin Shiekhattar Stephen Nimer TAF1 plays a critical role in AML1-ETO driven leukemogenesis
description	AML1-ETO is a fusion protein in which acetylation of lysine-43 is critical to leukemogenesis. Here, they show that TAF1 is required for AML1-ETO mediated gene expression such that it binds to acetylated AML1-ETO to facilitate the association of AML1-ETO with chromatin, and consequently, promotes leukemic self-renewal.
format	article
author	Ye Xu Na Man Daniel Karl Concepcion Martinez Fan Liu Jun Sun Camilo Jose Martinez Gloria Mas Martin Felipe Beckedorff Fan Lai Jingyin Yue Alejandro Roisman Sarah Greenblatt Stephanie Duffort Lan Wang Xiaojian Sun Maria Figueroa Ramin Shiekhattar Stephen Nimer
author_facet	Ye Xu Na Man Daniel Karl Concepcion Martinez Fan Liu Jun Sun Camilo Jose Martinez Gloria Mas Martin Felipe Beckedorff Fan Lai Jingyin Yue Alejandro Roisman Sarah Greenblatt Stephanie Duffort Lan Wang Xiaojian Sun Maria Figueroa Ramin Shiekhattar Stephen Nimer
author_sort	Ye Xu
title	TAF1 plays a critical role in AML1-ETO driven leukemogenesis
title_short	TAF1 plays a critical role in AML1-ETO driven leukemogenesis
title_full	TAF1 plays a critical role in AML1-ETO driven leukemogenesis
title_fullStr	TAF1 plays a critical role in AML1-ETO driven leukemogenesis
title_full_unstemmed	TAF1 plays a critical role in AML1-ETO driven leukemogenesis
title_sort	taf1 plays a critical role in aml1-eto driven leukemogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7c876bc2dac14cc194b471dadcb6299e
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TAF1 plays a critical role in AML1-ETO driven leukemogenesis

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