Molecular principles underlying dual RNA specificity in the Drosophila SNF protein
It remains poorly understood how a single RNA-binding protein recognizes diverse RNA targets. Here the authors use an integrative approach to study the binding of spliceosomal SNF protein to U1 and U2 small nuclear RNAs in the presence or absence of auxiliary protein U2A’ and show how SNF’s conforma...
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Nature Portfolio
2018
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oai:doaj.org-article:7c88ead7df1b4767aff31b12d5ce58642021-12-02T15:33:53ZMolecular principles underlying dual RNA specificity in the Drosophila SNF protein10.1038/s41467-018-04561-62041-1723https://doaj.org/article/7c88ead7df1b4767aff31b12d5ce58642018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04561-6https://doaj.org/toc/2041-1723It remains poorly understood how a single RNA-binding protein recognizes diverse RNA targets. Here the authors use an integrative approach to study the binding of spliceosomal SNF protein to U1 and U2 small nuclear RNAs in the presence or absence of auxiliary protein U2A’ and show how SNF’s conformational dynamics are tuned to recognize different stem-loop structures.Gert WeberGregory T. DeKosterNicole HoltonKathleen B. HallMarkus C. WahlNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018) |
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Science Q Gert Weber Gregory T. DeKoster Nicole Holton Kathleen B. Hall Markus C. Wahl Molecular principles underlying dual RNA specificity in the Drosophila SNF protein |
description |
It remains poorly understood how a single RNA-binding protein recognizes diverse RNA targets. Here the authors use an integrative approach to study the binding of spliceosomal SNF protein to U1 and U2 small nuclear RNAs in the presence or absence of auxiliary protein U2A’ and show how SNF’s conformational dynamics are tuned to recognize different stem-loop structures. |
format |
article |
author |
Gert Weber Gregory T. DeKoster Nicole Holton Kathleen B. Hall Markus C. Wahl |
author_facet |
Gert Weber Gregory T. DeKoster Nicole Holton Kathleen B. Hall Markus C. Wahl |
author_sort |
Gert Weber |
title |
Molecular principles underlying dual RNA specificity in the Drosophila SNF protein |
title_short |
Molecular principles underlying dual RNA specificity in the Drosophila SNF protein |
title_full |
Molecular principles underlying dual RNA specificity in the Drosophila SNF protein |
title_fullStr |
Molecular principles underlying dual RNA specificity in the Drosophila SNF protein |
title_full_unstemmed |
Molecular principles underlying dual RNA specificity in the Drosophila SNF protein |
title_sort |
molecular principles underlying dual rna specificity in the drosophila snf protein |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/7c88ead7df1b4767aff31b12d5ce5864 |
work_keys_str_mv |
AT gertweber molecularprinciplesunderlyingdualrnaspecificityinthedrosophilasnfprotein AT gregorytdekoster molecularprinciplesunderlyingdualrnaspecificityinthedrosophilasnfprotein AT nicoleholton molecularprinciplesunderlyingdualrnaspecificityinthedrosophilasnfprotein AT kathleenbhall molecularprinciplesunderlyingdualrnaspecificityinthedrosophilasnfprotein AT markuscwahl molecularprinciplesunderlyingdualrnaspecificityinthedrosophilasnfprotein |
_version_ |
1718386971223523328 |