Molecular principles underlying dual RNA specificity in the Drosophila SNF protein

It remains poorly understood how a single RNA-binding protein recognizes diverse RNA targets. Here the authors use an integrative approach to study the binding of spliceosomal SNF protein to U1 and U2 small nuclear RNAs in the presence or absence of auxiliary protein U2A’ and show how SNF’s conforma...

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Autores principales: Gert Weber, Gregory T. DeKoster, Nicole Holton, Kathleen B. Hall, Markus C. Wahl
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/7c88ead7df1b4767aff31b12d5ce5864
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spelling oai:doaj.org-article:7c88ead7df1b4767aff31b12d5ce58642021-12-02T15:33:53ZMolecular principles underlying dual RNA specificity in the Drosophila SNF protein10.1038/s41467-018-04561-62041-1723https://doaj.org/article/7c88ead7df1b4767aff31b12d5ce58642018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04561-6https://doaj.org/toc/2041-1723It remains poorly understood how a single RNA-binding protein recognizes diverse RNA targets. Here the authors use an integrative approach to study the binding of spliceosomal SNF protein to U1 and U2 small nuclear RNAs in the presence or absence of auxiliary protein U2A’ and show how SNF’s conformational dynamics are tuned to recognize different stem-loop structures.Gert WeberGregory T. DeKosterNicole HoltonKathleen B. HallMarkus C. WahlNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Gert Weber
Gregory T. DeKoster
Nicole Holton
Kathleen B. Hall
Markus C. Wahl
Molecular principles underlying dual RNA specificity in the Drosophila SNF protein
description It remains poorly understood how a single RNA-binding protein recognizes diverse RNA targets. Here the authors use an integrative approach to study the binding of spliceosomal SNF protein to U1 and U2 small nuclear RNAs in the presence or absence of auxiliary protein U2A’ and show how SNF’s conformational dynamics are tuned to recognize different stem-loop structures.
format article
author Gert Weber
Gregory T. DeKoster
Nicole Holton
Kathleen B. Hall
Markus C. Wahl
author_facet Gert Weber
Gregory T. DeKoster
Nicole Holton
Kathleen B. Hall
Markus C. Wahl
author_sort Gert Weber
title Molecular principles underlying dual RNA specificity in the Drosophila SNF protein
title_short Molecular principles underlying dual RNA specificity in the Drosophila SNF protein
title_full Molecular principles underlying dual RNA specificity in the Drosophila SNF protein
title_fullStr Molecular principles underlying dual RNA specificity in the Drosophila SNF protein
title_full_unstemmed Molecular principles underlying dual RNA specificity in the Drosophila SNF protein
title_sort molecular principles underlying dual rna specificity in the drosophila snf protein
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/7c88ead7df1b4767aff31b12d5ce5864
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AT nicoleholton molecularprinciplesunderlyingdualrnaspecificityinthedrosophilasnfprotein
AT kathleenbhall molecularprinciplesunderlyingdualrnaspecificityinthedrosophilasnfprotein
AT markuscwahl molecularprinciplesunderlyingdualrnaspecificityinthedrosophilasnfprotein
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