Molecular principles underlying dual RNA specificity in the Drosophila SNF protein

It remains poorly understood how a single RNA-binding protein recognizes diverse RNA targets. Here the authors use an integrative approach to study the binding of spliceosomal SNF protein to U1 and U2 small nuclear RNAs in the presence or absence of auxiliary protein U2A’ and show how SNF’s conforma...

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Auteurs principaux:	Gert Weber, Gregory T. DeKoster, Nicole Holton, Kathleen B. Hall, Markus C. Wahl
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/7c88ead7df1b4767aff31b12d5ce5864
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spelling	oai:doaj.org-article:7c88ead7df1b4767aff31b12d5ce58642021-12-02T15:33:53ZMolecular principles underlying dual RNA specificity in the Drosophila SNF protein10.1038/s41467-018-04561-62041-1723https://doaj.org/article/7c88ead7df1b4767aff31b12d5ce58642018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04561-6https://doaj.org/toc/2041-1723It remains poorly understood how a single RNA-binding protein recognizes diverse RNA targets. Here the authors use an integrative approach to study the binding of spliceosomal SNF protein to U1 and U2 small nuclear RNAs in the presence or absence of auxiliary protein U2A’ and show how SNF’s conformational dynamics are tuned to recognize different stem-loop structures.Gert WeberGregory T. DeKosterNicole HoltonKathleen B. HallMarkus C. WahlNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gert Weber Gregory T. DeKoster Nicole Holton Kathleen B. Hall Markus C. Wahl Molecular principles underlying dual RNA specificity in the Drosophila SNF protein
description	It remains poorly understood how a single RNA-binding protein recognizes diverse RNA targets. Here the authors use an integrative approach to study the binding of spliceosomal SNF protein to U1 and U2 small nuclear RNAs in the presence or absence of auxiliary protein U2A’ and show how SNF’s conformational dynamics are tuned to recognize different stem-loop structures.
format	article
author	Gert Weber Gregory T. DeKoster Nicole Holton Kathleen B. Hall Markus C. Wahl
author_facet	Gert Weber Gregory T. DeKoster Nicole Holton Kathleen B. Hall Markus C. Wahl
author_sort	Gert Weber
title	Molecular principles underlying dual RNA specificity in the Drosophila SNF protein
title_short	Molecular principles underlying dual RNA specificity in the Drosophila SNF protein
title_full	Molecular principles underlying dual RNA specificity in the Drosophila SNF protein
title_fullStr	Molecular principles underlying dual RNA specificity in the Drosophila SNF protein
title_full_unstemmed	Molecular principles underlying dual RNA specificity in the Drosophila SNF protein
title_sort	molecular principles underlying dual rna specificity in the drosophila snf protein
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7c88ead7df1b4767aff31b12d5ce5864
work_keys_str_mv	AT gertweber molecularprinciplesunderlyingdualrnaspecificityinthedrosophilasnfprotein AT gregorytdekoster molecularprinciplesunderlyingdualrnaspecificityinthedrosophilasnfprotein AT nicoleholton molecularprinciplesunderlyingdualrnaspecificityinthedrosophilasnfprotein AT kathleenbhall molecularprinciplesunderlyingdualrnaspecificityinthedrosophilasnfprotein AT markuscwahl molecularprinciplesunderlyingdualrnaspecificityinthedrosophilasnfprotein
_version_	1718386971223523328

Molecular principles underlying dual RNA specificity in the Drosophila SNF protein

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