METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells

Post transcriptional modifications to RNA may be important in the function of NK cells but this is not fully known. Here the authors show that m6A-methyltransferase METTL3 deletion in NK cells leads to reduced function and protection against tumour challenge through suppressing response to IL-15.

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Autores principales:	Hao Song, Jiaxi Song, Ming Cheng, Meijuan Zheng, Tian Wang, Sha Tian, Richard A. Flavell, Shu Zhu, Hua-Bing Li, Chen Ding, Haiming Wei, Rui Sun, Hui Peng, Zhigang Tian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7c8a5352b1e0420daf32014d1ad232bd
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spelling	oai:doaj.org-article:7c8a5352b1e0420daf32014d1ad232bd2021-12-02T17:24:12ZMETTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells10.1038/s41467-021-25803-02041-1723https://doaj.org/article/7c8a5352b1e0420daf32014d1ad232bd2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25803-0https://doaj.org/toc/2041-1723Post transcriptional modifications to RNA may be important in the function of NK cells but this is not fully known. Here the authors show that m6A-methyltransferase METTL3 deletion in NK cells leads to reduced function and protection against tumour challenge through suppressing response to IL-15.Hao SongJiaxi SongMing ChengMeijuan ZhengTian WangSha TianRichard A. FlavellShu ZhuHua-Bing LiChen DingHaiming WeiRui SunHui PengZhigang TianNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hao Song Jiaxi Song Ming Cheng Meijuan Zheng Tian Wang Sha Tian Richard A. Flavell Shu Zhu Hua-Bing Li Chen Ding Haiming Wei Rui Sun Hui Peng Zhigang Tian METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells
description	Post transcriptional modifications to RNA may be important in the function of NK cells but this is not fully known. Here the authors show that m6A-methyltransferase METTL3 deletion in NK cells leads to reduced function and protection against tumour challenge through suppressing response to IL-15.
format	article
author	Hao Song Jiaxi Song Ming Cheng Meijuan Zheng Tian Wang Sha Tian Richard A. Flavell Shu Zhu Hua-Bing Li Chen Ding Haiming Wei Rui Sun Hui Peng Zhigang Tian
author_facet	Hao Song Jiaxi Song Ming Cheng Meijuan Zheng Tian Wang Sha Tian Richard A. Flavell Shu Zhu Hua-Bing Li Chen Ding Haiming Wei Rui Sun Hui Peng Zhigang Tian
author_sort	Hao Song
title	METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells
title_short	METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells
title_full	METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells
title_fullStr	METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells
title_full_unstemmed	METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells
title_sort	mettl3-mediated m6a rna methylation promotes the anti-tumour immunity of natural killer cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7c8a5352b1e0420daf32014d1ad232bd
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METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells

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