CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis

CD103+ dendritic cells induce iTreg cells to maintain immune balance in the gut, but how CD40-signalling regulates this process is unclear. Here the authors show that mice with constitutive CD11c-specific CD40-signalling have altered CD103+dendritic cell migration, reduced iTreg cell induction, and...

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Autores principales:	Christian Barthels, Ana Ogrinc, Verena Steyer, Stefanie Meier, Ferdinand Simon, Maria Wimmer, Andreas Blutke, Tobias Straub, Ursula Zimber-Strobl, Esther Lutgens, Peggy Marconi, Caspar Ohnmacht, Debora Garzetti, Bärbel Stecher, Thomas Brocker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7c8b4bc021104cd99b9d6bf8099e2013
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spelling	oai:doaj.org-article:7c8b4bc021104cd99b9d6bf8099e20132021-12-02T15:37:07ZCD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis10.1038/ncomms147152041-1723https://doaj.org/article/7c8b4bc021104cd99b9d6bf8099e20132017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14715https://doaj.org/toc/2041-1723CD103+ dendritic cells induce iTreg cells to maintain immune balance in the gut, but how CD40-signalling regulates this process is unclear. Here the authors show that mice with constitutive CD11c-specific CD40-signalling have altered CD103+dendritic cell migration, reduced iTreg cell induction, and fatal colitis.Christian BarthelsAna OgrincVerena SteyerStefanie MeierFerdinand SimonMaria WimmerAndreas BlutkeTobias StraubUrsula Zimber-StroblEsther LutgensPeggy MarconiCaspar OhnmachtDebora GarzettiBärbel StecherThomas BrockerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christian Barthels Ana Ogrinc Verena Steyer Stefanie Meier Ferdinand Simon Maria Wimmer Andreas Blutke Tobias Straub Ursula Zimber-Strobl Esther Lutgens Peggy Marconi Caspar Ohnmacht Debora Garzetti Bärbel Stecher Thomas Brocker CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis
description	CD103+ dendritic cells induce iTreg cells to maintain immune balance in the gut, but how CD40-signalling regulates this process is unclear. Here the authors show that mice with constitutive CD11c-specific CD40-signalling have altered CD103+dendritic cell migration, reduced iTreg cell induction, and fatal colitis.
format	article
author	Christian Barthels Ana Ogrinc Verena Steyer Stefanie Meier Ferdinand Simon Maria Wimmer Andreas Blutke Tobias Straub Ursula Zimber-Strobl Esther Lutgens Peggy Marconi Caspar Ohnmacht Debora Garzetti Bärbel Stecher Thomas Brocker
author_facet	Christian Barthels Ana Ogrinc Verena Steyer Stefanie Meier Ferdinand Simon Maria Wimmer Andreas Blutke Tobias Straub Ursula Zimber-Strobl Esther Lutgens Peggy Marconi Caspar Ohnmacht Debora Garzetti Bärbel Stecher Thomas Brocker
author_sort	Christian Barthels
title	CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis
title_short	CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis
title_full	CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis
title_fullStr	CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis
title_full_unstemmed	CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis
title_sort	cd40-signalling abrogates induction of rorγt+ treg cells by intestinal cd103+ dcs and causes fatal colitis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7c8b4bc021104cd99b9d6bf8099e2013
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CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis

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