SPAK Deficiency Attenuates Chemotherapy-Induced Intestinal Mucositis

SPAK Deficiency Attenuates Chemotherapy-Induced Intestinal Mucositis

IntroductionSte20-related protein proline/alanine-rich kinase (SPAK) affects cell proliferation, differentiation, and transformation, and sodium and chloride transport in the gut. However, its role in gut injury pathogenesis is unclear.ObjectiveWe determined the role of SPAK in chemotherapy-induced...

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Auteurs principaux: Tien-Yu Huang, Sung-Sen Yang, Ching-Len Liao, Ming-Hong Lin, Hsuan-Hwai Lin, Jung-Chun Lin, Peng-Jen Chen, Yu-Lueng Shih, Wei-Kuo Chang, Tsai-Yuan Hsieh
Format: article
Langue:EN
Publié: Frontiers Media S.A. 2021
Sujets:
chemotherapy-induced intestinal mucositis
gut homeostasis
enterocytes
tight junctions
small intestine
5-fluorouracil
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Accès en ligne:https://doaj.org/article/7c8b75489e844c939db758682077c78e
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https://doaj.org/article/7c8b75489e844c939db758682077c78e

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