The RNA-binding protein ARPP21 controls dendritic branching by functionally opposing the miRNA it hosts

Many microRNA encoding regions are within introns of other coding genes, and yet the molecular or functional interaction between the two is unclear. This study shows that miR-128′s function is opposed by its host gene ARPP21, and they have complementary effects on neuronal development.

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Autores principales:	Frederick Rehfeld, Daniel Maticzka, Sabine Grosser, Pina Knauff, Murat Eravci, Imre Vida, Rolf Backofen, F. Gregory Wulczyn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7c8b8c16051e47579746c26c47d7c3ac
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spelling	oai:doaj.org-article:7c8b8c16051e47579746c26c47d7c3ac2021-12-02T15:34:14ZThe RNA-binding protein ARPP21 controls dendritic branching by functionally opposing the miRNA it hosts10.1038/s41467-018-03681-32041-1723https://doaj.org/article/7c8b8c16051e47579746c26c47d7c3ac2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03681-3https://doaj.org/toc/2041-1723Many microRNA encoding regions are within introns of other coding genes, and yet the molecular or functional interaction between the two is unclear. This study shows that miR-128′s function is opposed by its host gene ARPP21, and they have complementary effects on neuronal development.Frederick RehfeldDaniel MaticzkaSabine GrosserPina KnauffMurat EravciImre VidaRolf BackofenF. Gregory WulczynNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Frederick Rehfeld Daniel Maticzka Sabine Grosser Pina Knauff Murat Eravci Imre Vida Rolf Backofen F. Gregory Wulczyn The RNA-binding protein ARPP21 controls dendritic branching by functionally opposing the miRNA it hosts
description	Many microRNA encoding regions are within introns of other coding genes, and yet the molecular or functional interaction between the two is unclear. This study shows that miR-128′s function is opposed by its host gene ARPP21, and they have complementary effects on neuronal development.
format	article
author	Frederick Rehfeld Daniel Maticzka Sabine Grosser Pina Knauff Murat Eravci Imre Vida Rolf Backofen F. Gregory Wulczyn
author_facet	Frederick Rehfeld Daniel Maticzka Sabine Grosser Pina Knauff Murat Eravci Imre Vida Rolf Backofen F. Gregory Wulczyn
author_sort	Frederick Rehfeld
title	The RNA-binding protein ARPP21 controls dendritic branching by functionally opposing the miRNA it hosts
title_short	The RNA-binding protein ARPP21 controls dendritic branching by functionally opposing the miRNA it hosts
title_full	The RNA-binding protein ARPP21 controls dendritic branching by functionally opposing the miRNA it hosts
title_fullStr	The RNA-binding protein ARPP21 controls dendritic branching by functionally opposing the miRNA it hosts
title_full_unstemmed	The RNA-binding protein ARPP21 controls dendritic branching by functionally opposing the miRNA it hosts
title_sort	rna-binding protein arpp21 controls dendritic branching by functionally opposing the mirna it hosts
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7c8b8c16051e47579746c26c47d7c3ac
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The RNA-binding protein ARPP21 controls dendritic branching by functionally opposing the miRNA it hosts

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