The Diagnostic, Prognostic and Therapeutic Role of miRNAs in Adrenocortical Carcinoma: A Systematic Review
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a dismal prognosis and a high rate of recurrence and mortality. Therapeutic options are limited. In some cases, the distinction of ACCs from benign adrenal neoplasms with the existing widely available pathological and histopathologic...
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oai:doaj.org-article:7c8bba912eb24955b4c6237e0e6d8def2021-11-25T16:48:19ZThe Diagnostic, Prognostic and Therapeutic Role of miRNAs in Adrenocortical Carcinoma: A Systematic Review10.3390/biomedicines91115012227-9059https://doaj.org/article/7c8bba912eb24955b4c6237e0e6d8def2021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1501https://doaj.org/toc/2227-9059Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a dismal prognosis and a high rate of recurrence and mortality. Therapeutic options are limited. In some cases, the distinction of ACCs from benign adrenal neoplasms with the existing widely available pathological and histopathological tools is difficult. Thus, new biomarkers have been tested. We conducted a review of the recent literature on the advances of the diagnostic, prognostic and therapeutic role of miRNAs on ACC patients. More than 10 miRNAs validated by multiple studies were found to present a diagnostic and prognostic role for ACC patients, from which miR-483-5p and miR-195 were the most frequently met biomarkers. In particular, upregulation of miR-483-5p and downregulation of miR-195 were the most commonly validated molecular alterations. Unfortunately, data on the therapeutic role of miRNA are still scarce and limited mainly at the experimental level. Thus, the role of miRNA regulation in ACC remains an area of active research.Chrysoula MytareliDanae A. DelivanisFani AthanassouliVassiliki KalotychouMarina MantzouraniEva KassiAnna AngelousiMDPI AGarticlemicroRNAsadrenocortical carcinomabiomarkersdiagnosisprognosistherapyBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1501, p 1501 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
microRNAs adrenocortical carcinoma biomarkers diagnosis prognosis therapy Biology (General) QH301-705.5 |
| spellingShingle |
microRNAs adrenocortical carcinoma biomarkers diagnosis prognosis therapy Biology (General) QH301-705.5 Chrysoula Mytareli Danae A. Delivanis Fani Athanassouli Vassiliki Kalotychou Marina Mantzourani Eva Kassi Anna Angelousi The Diagnostic, Prognostic and Therapeutic Role of miRNAs in Adrenocortical Carcinoma: A Systematic Review |
| description |
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a dismal prognosis and a high rate of recurrence and mortality. Therapeutic options are limited. In some cases, the distinction of ACCs from benign adrenal neoplasms with the existing widely available pathological and histopathological tools is difficult. Thus, new biomarkers have been tested. We conducted a review of the recent literature on the advances of the diagnostic, prognostic and therapeutic role of miRNAs on ACC patients. More than 10 miRNAs validated by multiple studies were found to present a diagnostic and prognostic role for ACC patients, from which miR-483-5p and miR-195 were the most frequently met biomarkers. In particular, upregulation of miR-483-5p and downregulation of miR-195 were the most commonly validated molecular alterations. Unfortunately, data on the therapeutic role of miRNA are still scarce and limited mainly at the experimental level. Thus, the role of miRNA regulation in ACC remains an area of active research. |
| format |
article |
| author |
Chrysoula Mytareli Danae A. Delivanis Fani Athanassouli Vassiliki Kalotychou Marina Mantzourani Eva Kassi Anna Angelousi |
| author_facet |
Chrysoula Mytareli Danae A. Delivanis Fani Athanassouli Vassiliki Kalotychou Marina Mantzourani Eva Kassi Anna Angelousi |
| author_sort |
Chrysoula Mytareli |
| title |
The Diagnostic, Prognostic and Therapeutic Role of miRNAs in Adrenocortical Carcinoma: A Systematic Review |
| title_short |
The Diagnostic, Prognostic and Therapeutic Role of miRNAs in Adrenocortical Carcinoma: A Systematic Review |
| title_full |
The Diagnostic, Prognostic and Therapeutic Role of miRNAs in Adrenocortical Carcinoma: A Systematic Review |
| title_fullStr |
The Diagnostic, Prognostic and Therapeutic Role of miRNAs in Adrenocortical Carcinoma: A Systematic Review |
| title_full_unstemmed |
The Diagnostic, Prognostic and Therapeutic Role of miRNAs in Adrenocortical Carcinoma: A Systematic Review |
| title_sort |
diagnostic, prognostic and therapeutic role of mirnas in adrenocortical carcinoma: a systematic review |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/7c8bba912eb24955b4c6237e0e6d8def |
| work_keys_str_mv |
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| _version_ |
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