On the function of biosynthesized cellulose as barrier against bacterial colonization of VAD drivelines

Abstract Bacterial colonization of drivelines represents a major adverse event in the implantation of left ventricular assist devices (L-VADs) for the treatment of congestive heart failure. From the external driveline interface and through the skin breach, pathogens can ascend to the pump pocket, en...

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Autores principales:	Julius Kaemmel, Aldo Ferrari, Francesco Robotti, Simone Bottan, Fritz Eichenseher, Tanja Schmidt, Mercedes Gonzalez Moreno, Andrej Trampuz, Jaime-Jürgen Eulert-Grehn, Christoph Knosalla, Evgenij Potapov, Volkmar Falk, Christoph Starck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7c8dc7b562cb4dd2bd1713fc0840b21a
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spelling	oai:doaj.org-article:7c8dc7b562cb4dd2bd1713fc0840b21a2021-12-02T18:48:01ZOn the function of biosynthesized cellulose as barrier against bacterial colonization of VAD drivelines10.1038/s41598-021-98220-42045-2322https://doaj.org/article/7c8dc7b562cb4dd2bd1713fc0840b21a2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98220-4https://doaj.org/toc/2045-2322Abstract Bacterial colonization of drivelines represents a major adverse event in the implantation of left ventricular assist devices (L-VADs) for the treatment of congestive heart failure. From the external driveline interface and through the skin breach, pathogens can ascend to the pump pocket, endangering the device function and the patient’s life. Surface Micro-Engineered Biosynthesized cellulose (BC) is an implantable biomaterial, which minimizes fibrotic tissue deposition and promotes healthy tissue regeneration. The topographic arrangement of cellulose fibers and the typical material porosity support its potential protective function against bacterial permeation; however, this application has not been tested in clinically relevant animal models. Here, a goat model was adopted to evaluate the barrier function of BC membranes. The external silicone mantle of commercial L-VAD drivelines was implanted percutaneously with an intervening layer of BC to separate them from the surrounding soft tissue. End-point evaluation at 6 and 12 weeks of two separate animal groups revealed the local bacterial colonization at the different interfaces in comparison with unprotected driveline mantle controls. The results demonstrate that the BC membranes established an effective barrier against the bacterial colonization of the outer driveline interface. The containment of pathogen infiltration, in combination with the known anti-fibrotic effect of BC, may promote a more efficient immune clearance upon driveline implantation and support the efficacy of local antibiotic treatments, therefore mitigating the risk connected to their percutaneous deployment.Julius KaemmelAldo FerrariFrancesco RobottiSimone BottanFritz EichenseherTanja SchmidtMercedes Gonzalez MorenoAndrej TrampuzJaime-Jürgen Eulert-GrehnChristoph KnosallaEvgenij PotapovVolkmar FalkChristoph StarckNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julius Kaemmel Aldo Ferrari Francesco Robotti Simone Bottan Fritz Eichenseher Tanja Schmidt Mercedes Gonzalez Moreno Andrej Trampuz Jaime-Jürgen Eulert-Grehn Christoph Knosalla Evgenij Potapov Volkmar Falk Christoph Starck On the function of biosynthesized cellulose as barrier against bacterial colonization of VAD drivelines
description	Abstract Bacterial colonization of drivelines represents a major adverse event in the implantation of left ventricular assist devices (L-VADs) for the treatment of congestive heart failure. From the external driveline interface and through the skin breach, pathogens can ascend to the pump pocket, endangering the device function and the patient’s life. Surface Micro-Engineered Biosynthesized cellulose (BC) is an implantable biomaterial, which minimizes fibrotic tissue deposition and promotes healthy tissue regeneration. The topographic arrangement of cellulose fibers and the typical material porosity support its potential protective function against bacterial permeation; however, this application has not been tested in clinically relevant animal models. Here, a goat model was adopted to evaluate the barrier function of BC membranes. The external silicone mantle of commercial L-VAD drivelines was implanted percutaneously with an intervening layer of BC to separate them from the surrounding soft tissue. End-point evaluation at 6 and 12 weeks of two separate animal groups revealed the local bacterial colonization at the different interfaces in comparison with unprotected driveline mantle controls. The results demonstrate that the BC membranes established an effective barrier against the bacterial colonization of the outer driveline interface. The containment of pathogen infiltration, in combination with the known anti-fibrotic effect of BC, may promote a more efficient immune clearance upon driveline implantation and support the efficacy of local antibiotic treatments, therefore mitigating the risk connected to their percutaneous deployment.
format	article
author	Julius Kaemmel Aldo Ferrari Francesco Robotti Simone Bottan Fritz Eichenseher Tanja Schmidt Mercedes Gonzalez Moreno Andrej Trampuz Jaime-Jürgen Eulert-Grehn Christoph Knosalla Evgenij Potapov Volkmar Falk Christoph Starck
author_facet	Julius Kaemmel Aldo Ferrari Francesco Robotti Simone Bottan Fritz Eichenseher Tanja Schmidt Mercedes Gonzalez Moreno Andrej Trampuz Jaime-Jürgen Eulert-Grehn Christoph Knosalla Evgenij Potapov Volkmar Falk Christoph Starck
author_sort	Julius Kaemmel
title	On the function of biosynthesized cellulose as barrier against bacterial colonization of VAD drivelines
title_short	On the function of biosynthesized cellulose as barrier against bacterial colonization of VAD drivelines
title_full	On the function of biosynthesized cellulose as barrier against bacterial colonization of VAD drivelines
title_fullStr	On the function of biosynthesized cellulose as barrier against bacterial colonization of VAD drivelines
title_full_unstemmed	On the function of biosynthesized cellulose as barrier against bacterial colonization of VAD drivelines
title_sort	on the function of biosynthesized cellulose as barrier against bacterial colonization of vad drivelines
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7c8dc7b562cb4dd2bd1713fc0840b21a
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On the function of biosynthesized cellulose as barrier against bacterial colonization of VAD drivelines

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