Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice

Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice

Mutations in the translational activator of cytochrome c oxidase subunit I (TACO1) causes cytochrome c oxidase deficiency and Leigh Syndrome in patients. Here, the authors characterize mice with a mutation that causes lack of TACO1 expression, identifying a mouse model that could be useful for precl...

Full description

Saved in:
Bibliographic Details
Main Authors: Tara R. Richman, Henrik Spåhr, Judith A. Ermer, Stefan M. K. Davies, Helena M. Viola, Kristyn A. Bates, John Papadimitriou, Livia C. Hool, Jennifer Rodger, Nils-Göran Larsson, Oliver Rackham, Aleksandra Filipovska
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
Q
Online Access:https://doaj.org/article/7c8e652660f64c7ba9ff15b23fd6d83c
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mutations in the translational activator of cytochrome c oxidase subunit I (TACO1) causes cytochrome c oxidase deficiency and Leigh Syndrome in patients. Here, the authors characterize mice with a mutation that causes lack of TACO1 expression, identifying a mouse model that could be useful for preclinical trials.

Similar Items