Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice

Mutations in the translational activator of cytochrome c oxidase subunit I (TACO1) causes cytochrome c oxidase deficiency and Leigh Syndrome in patients. Here, the authors characterize mice with a mutation that causes lack of TACO1 expression, identifying a mouse model that could be useful for precl...

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Autores principales:	Tara R. Richman, Henrik Spåhr, Judith A. Ermer, Stefan M. K. Davies, Helena M. Viola, Kristyn A. Bates, John Papadimitriou, Livia C. Hool, Jennifer Rodger, Nils-Göran Larsson, Oliver Rackham, Aleksandra Filipovska
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7c8e652660f64c7ba9ff15b23fd6d83c
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spelling	oai:doaj.org-article:7c8e652660f64c7ba9ff15b23fd6d83c2021-12-02T14:38:34ZLoss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice10.1038/ncomms118842041-1723https://doaj.org/article/7c8e652660f64c7ba9ff15b23fd6d83c2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11884https://doaj.org/toc/2041-1723Mutations in the translational activator of cytochrome c oxidase subunit I (TACO1) causes cytochrome c oxidase deficiency and Leigh Syndrome in patients. Here, the authors characterize mice with a mutation that causes lack of TACO1 expression, identifying a mouse model that could be useful for preclinical trials.Tara R. RichmanHenrik SpåhrJudith A. ErmerStefan M. K. DaviesHelena M. ViolaKristyn A. BatesJohn PapadimitriouLivia C. HoolJennifer RodgerNils-Göran LarssonOliver RackhamAleksandra FilipovskaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tara R. Richman Henrik Spåhr Judith A. Ermer Stefan M. K. Davies Helena M. Viola Kristyn A. Bates John Papadimitriou Livia C. Hool Jennifer Rodger Nils-Göran Larsson Oliver Rackham Aleksandra Filipovska Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice
description	Mutations in the translational activator of cytochrome c oxidase subunit I (TACO1) causes cytochrome c oxidase deficiency and Leigh Syndrome in patients. Here, the authors characterize mice with a mutation that causes lack of TACO1 expression, identifying a mouse model that could be useful for preclinical trials.
format	article
author	Tara R. Richman Henrik Spåhr Judith A. Ermer Stefan M. K. Davies Helena M. Viola Kristyn A. Bates John Papadimitriou Livia C. Hool Jennifer Rodger Nils-Göran Larsson Oliver Rackham Aleksandra Filipovska
author_facet	Tara R. Richman Henrik Spåhr Judith A. Ermer Stefan M. K. Davies Helena M. Viola Kristyn A. Bates John Papadimitriou Livia C. Hool Jennifer Rodger Nils-Göran Larsson Oliver Rackham Aleksandra Filipovska
author_sort	Tara R. Richman
title	Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice
title_short	Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice
title_full	Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice
title_fullStr	Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice
title_full_unstemmed	Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice
title_sort	loss of the rna-binding protein taco1 causes late-onset mitochondrial dysfunction in mice
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7c8e652660f64c7ba9ff15b23fd6d83c
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Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice

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