Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice

Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice

Mutations in the translational activator of cytochrome c oxidase subunit I (TACO1) causes cytochrome c oxidase deficiency and Leigh Syndrome in patients. Here, the authors characterize mice with a mutation that causes lack of TACO1 expression, identifying a mouse model that could be useful for precl...

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Autores principales: Tara R. Richman, Henrik Spåhr, Judith A. Ermer, Stefan M. K. Davies, Helena M. Viola, Kristyn A. Bates, John Papadimitriou, Livia C. Hool, Jennifer Rodger, Nils-Göran Larsson, Oliver Rackham, Aleksandra Filipovska
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/7c8e652660f64c7ba9ff15b23fd6d83c
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