HIV-1 and HIV-2 prevalence, risk factors and birth outcomes among pregnant women in Bissau, Guinea-Bissau: a retrospective cross-sectional hospital study

Abstract The human immunodeficiency virus (HIV) remains a leading cause of maternal morbidity and mortality in Sub-Saharan Africa. Prevention of mother-to-child transmission (PMTCT) has proven an effective strategy to end paediatric infections and ensure HIV-infected mothers access treatment. Based...

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Autores principales:	Dlama Nggida Rasmussen, Noel Vieira, Bo Langhoff Hønge, David da Silva Té, Sanne Jespersen, Morten Bjerregaard-Andersen, Inés Oliveira, Alcino Furtado, Magarida Alfredo Gomes, Morten Sodemann, Christian Wejse, Holger Werner Unger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7c990701cf024123a502cb96af61f289
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spelling	oai:doaj.org-article:7c990701cf024123a502cb96af61f2892021-12-02T17:55:13ZHIV-1 and HIV-2 prevalence, risk factors and birth outcomes among pregnant women in Bissau, Guinea-Bissau: a retrospective cross-sectional hospital study10.1038/s41598-020-68806-52045-2322https://doaj.org/article/7c990701cf024123a502cb96af61f2892020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-68806-5https://doaj.org/toc/2045-2322Abstract The human immunodeficiency virus (HIV) remains a leading cause of maternal morbidity and mortality in Sub-Saharan Africa. Prevention of mother-to-child transmission (PMTCT) has proven an effective strategy to end paediatric infections and ensure HIV-infected mothers access treatment. Based on cross-sectional data collected from June 2008 to May 2013, we assessed changes in HIV prevalence, risk factors for HIV, provision of PMTCT antiretroviral treatment (ART), and the association between HIV infection, birth outcomes and maternal characteristics at the Simão Mendes National Hospital, Guinea-Bissau’s largest maternity ward. Among 24,107 women, the HIV prevalence was 3.3% for HIV-1, 0.8% for HIV-2 and 0.9% for HIV-1/2. A significant decline in HIV-1, HIV-2, and HIV-1/2 prevalence was observed over time. HIV infection was associated with age and ethnicity. A total of 85% of HIV-infected women received ART as part of PMTCT, yet overall treatment coverage during labour and delivery declined significantly for both mothers and infants. Twenty-two percent of infants did not receive treatment, and 67% of HIV-2-infected mothers and 77% of their infants received ineffective non-nucleoside reverse transcriptase inhibitors for PMTCT. Maternal HIV was associated with low birth weight but not stillbirth. Inadequate continuity of care and ART coverage present challenges to optimal PMTCT in Guinea-Bissau.Dlama Nggida RasmussenNoel VieiraBo Langhoff HøngeDavid da Silva TéSanne JespersenMorten Bjerregaard-AndersenInés OliveiraAlcino FurtadoMagarida Alfredo GomesMorten SodemannChristian WejseHolger Werner UngerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dlama Nggida Rasmussen Noel Vieira Bo Langhoff Hønge David da Silva Té Sanne Jespersen Morten Bjerregaard-Andersen Inés Oliveira Alcino Furtado Magarida Alfredo Gomes Morten Sodemann Christian Wejse Holger Werner Unger HIV-1 and HIV-2 prevalence, risk factors and birth outcomes among pregnant women in Bissau, Guinea-Bissau: a retrospective cross-sectional hospital study
description	Abstract The human immunodeficiency virus (HIV) remains a leading cause of maternal morbidity and mortality in Sub-Saharan Africa. Prevention of mother-to-child transmission (PMTCT) has proven an effective strategy to end paediatric infections and ensure HIV-infected mothers access treatment. Based on cross-sectional data collected from June 2008 to May 2013, we assessed changes in HIV prevalence, risk factors for HIV, provision of PMTCT antiretroviral treatment (ART), and the association between HIV infection, birth outcomes and maternal characteristics at the Simão Mendes National Hospital, Guinea-Bissau’s largest maternity ward. Among 24,107 women, the HIV prevalence was 3.3% for HIV-1, 0.8% for HIV-2 and 0.9% for HIV-1/2. A significant decline in HIV-1, HIV-2, and HIV-1/2 prevalence was observed over time. HIV infection was associated with age and ethnicity. A total of 85% of HIV-infected women received ART as part of PMTCT, yet overall treatment coverage during labour and delivery declined significantly for both mothers and infants. Twenty-two percent of infants did not receive treatment, and 67% of HIV-2-infected mothers and 77% of their infants received ineffective non-nucleoside reverse transcriptase inhibitors for PMTCT. Maternal HIV was associated with low birth weight but not stillbirth. Inadequate continuity of care and ART coverage present challenges to optimal PMTCT in Guinea-Bissau.
format	article
author	Dlama Nggida Rasmussen Noel Vieira Bo Langhoff Hønge David da Silva Té Sanne Jespersen Morten Bjerregaard-Andersen Inés Oliveira Alcino Furtado Magarida Alfredo Gomes Morten Sodemann Christian Wejse Holger Werner Unger
author_facet	Dlama Nggida Rasmussen Noel Vieira Bo Langhoff Hønge David da Silva Té Sanne Jespersen Morten Bjerregaard-Andersen Inés Oliveira Alcino Furtado Magarida Alfredo Gomes Morten Sodemann Christian Wejse Holger Werner Unger
author_sort	Dlama Nggida Rasmussen
title	HIV-1 and HIV-2 prevalence, risk factors and birth outcomes among pregnant women in Bissau, Guinea-Bissau: a retrospective cross-sectional hospital study
title_short	HIV-1 and HIV-2 prevalence, risk factors and birth outcomes among pregnant women in Bissau, Guinea-Bissau: a retrospective cross-sectional hospital study
title_full	HIV-1 and HIV-2 prevalence, risk factors and birth outcomes among pregnant women in Bissau, Guinea-Bissau: a retrospective cross-sectional hospital study
title_fullStr	HIV-1 and HIV-2 prevalence, risk factors and birth outcomes among pregnant women in Bissau, Guinea-Bissau: a retrospective cross-sectional hospital study
title_full_unstemmed	HIV-1 and HIV-2 prevalence, risk factors and birth outcomes among pregnant women in Bissau, Guinea-Bissau: a retrospective cross-sectional hospital study
title_sort	hiv-1 and hiv-2 prevalence, risk factors and birth outcomes among pregnant women in bissau, guinea-bissau: a retrospective cross-sectional hospital study
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7c990701cf024123a502cb96af61f289
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HIV-1 and HIV-2 prevalence, risk factors and birth outcomes among pregnant women in Bissau, Guinea-Bissau: a retrospective cross-sectional hospital study

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