The potential of Zishen Yutai pills to facilitate endometrial recovery and restore fertility after induced abortion in rats

Context Abortions damage the endometrium in women. Currently, therapeutic options for endometrial recovery are limited. Zishen Yutai Pill (ZYP) was found to promote endometrial blood supply as a traditional Chinese medicine. However, whether ZYP promotes endometrial recovery post-abortion has not ye...

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Autores principales:	Mianmian Li, Na Ning, Yu Liu, Xiaohui Li, Qiaojuan Mei, Jiebin Zhou, Qiuling Huang, Wenpei Xiang, Ling Zhang, Xiaoyan Xu
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	intrauterine injuries endometrium fibrosis endometrial receptivity pinopodes Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/7c99ae06a9bb49969619e05313154f4d
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spelling	oai:doaj.org-article:7c99ae06a9bb49969619e05313154f4d2021-11-04T15:00:42ZThe potential of Zishen Yutai pills to facilitate endometrial recovery and restore fertility after induced abortion in rats1388-02091744-511610.1080/13880209.2021.1993272https://doaj.org/article/7c99ae06a9bb49969619e05313154f4d2021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13880209.2021.1993272https://doaj.org/toc/1388-0209https://doaj.org/toc/1744-5116Context Abortions damage the endometrium in women. Currently, therapeutic options for endometrial recovery are limited. Zishen Yutai Pill (ZYP) was found to promote endometrial blood supply as a traditional Chinese medicine. However, whether ZYP promotes endometrial recovery post-abortion has not yet been explored. Objective This study evaluated the role of ZYP in rat endometrial recovery after induced abortion and explored its mechanism of action. Materials and methods Sprague–Dawley rats were divided into three groups: no-operation group, control group, and ZYP group. The rats in the control and ZYP group were induced abortion, and then treated with normal saline or ZYPs, respectively, for 1–3 oestrous cycles. Morphological changes in the endometrium were examined. Expression levels of the factors related to endometrial recovery were analyzed. The duration of this study was almost seven months. Results The endometrial thickness (7.3 ± 0.17 mm) and number of glands (5.5 ± 0.20) increased significantly in the ZYP group compared with those in the control group (5.5 ± 0.15 mm and 3.5 ± 0.18; p < 0.05). Fibrosis of the endometrium was ameliorated by ZYP administration (45 ± 6% vs. 58 ± 7%; p < 0.05). ZYPs treatment increased the expression of VEGF, ER, MMP-9, LIF, and HB-EGF, but decreased TGF-β expression. Moreover, the average number of pups in the ZYP group (9.0 ± 1.5) was greater than that in the control (4 ± 1.3). Discussion and conclusion ZYPs accelerate endometrial recovery and restored fertility in rats, suggesting its potential to promote human endometrial repair.Mianmian LiNa NingYu LiuXiaohui LiQiaojuan MeiJiebin ZhouQiuling HuangWenpei XiangLing ZhangXiaoyan XuTaylor & Francis Grouparticleintrauterine injuriesendometriumfibrosisendometrial receptivitypinopodesTherapeutics. PharmacologyRM1-950ENPharmaceutical Biology, Vol 59, Iss 1, Pp 1505-1516 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	intrauterine injuries endometrium fibrosis endometrial receptivity pinopodes Therapeutics. Pharmacology RM1-950
spellingShingle	intrauterine injuries endometrium fibrosis endometrial receptivity pinopodes Therapeutics. Pharmacology RM1-950 Mianmian Li Na Ning Yu Liu Xiaohui Li Qiaojuan Mei Jiebin Zhou Qiuling Huang Wenpei Xiang Ling Zhang Xiaoyan Xu The potential of Zishen Yutai pills to facilitate endometrial recovery and restore fertility after induced abortion in rats
description	Context Abortions damage the endometrium in women. Currently, therapeutic options for endometrial recovery are limited. Zishen Yutai Pill (ZYP) was found to promote endometrial blood supply as a traditional Chinese medicine. However, whether ZYP promotes endometrial recovery post-abortion has not yet been explored. Objective This study evaluated the role of ZYP in rat endometrial recovery after induced abortion and explored its mechanism of action. Materials and methods Sprague–Dawley rats were divided into three groups: no-operation group, control group, and ZYP group. The rats in the control and ZYP group were induced abortion, and then treated with normal saline or ZYPs, respectively, for 1–3 oestrous cycles. Morphological changes in the endometrium were examined. Expression levels of the factors related to endometrial recovery were analyzed. The duration of this study was almost seven months. Results The endometrial thickness (7.3 ± 0.17 mm) and number of glands (5.5 ± 0.20) increased significantly in the ZYP group compared with those in the control group (5.5 ± 0.15 mm and 3.5 ± 0.18; p < 0.05). Fibrosis of the endometrium was ameliorated by ZYP administration (45 ± 6% vs. 58 ± 7%; p < 0.05). ZYPs treatment increased the expression of VEGF, ER, MMP-9, LIF, and HB-EGF, but decreased TGF-β expression. Moreover, the average number of pups in the ZYP group (9.0 ± 1.5) was greater than that in the control (4 ± 1.3). Discussion and conclusion ZYPs accelerate endometrial recovery and restored fertility in rats, suggesting its potential to promote human endometrial repair.
format	article
author	Mianmian Li Na Ning Yu Liu Xiaohui Li Qiaojuan Mei Jiebin Zhou Qiuling Huang Wenpei Xiang Ling Zhang Xiaoyan Xu
author_facet	Mianmian Li Na Ning Yu Liu Xiaohui Li Qiaojuan Mei Jiebin Zhou Qiuling Huang Wenpei Xiang Ling Zhang Xiaoyan Xu
author_sort	Mianmian Li
title	The potential of Zishen Yutai pills to facilitate endometrial recovery and restore fertility after induced abortion in rats
title_short	The potential of Zishen Yutai pills to facilitate endometrial recovery and restore fertility after induced abortion in rats
title_full	The potential of Zishen Yutai pills to facilitate endometrial recovery and restore fertility after induced abortion in rats
title_fullStr	The potential of Zishen Yutai pills to facilitate endometrial recovery and restore fertility after induced abortion in rats
title_full_unstemmed	The potential of Zishen Yutai pills to facilitate endometrial recovery and restore fertility after induced abortion in rats
title_sort	potential of zishen yutai pills to facilitate endometrial recovery and restore fertility after induced abortion in rats
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/7c99ae06a9bb49969619e05313154f4d
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The potential of Zishen Yutai pills to facilitate endometrial recovery and restore fertility after induced abortion in rats

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