A New Role for Extracellular Vesicles in Cardiac Tissue Engineering and Regenerative Medicine

Cardiovascular diseases are the leading cause of death worldwide. Discovering new therapies to treat heart disease requires improved understanding of cardiac physiology at a cellular level. Extracellular vesicles (EVs) are plasma membrane‐bound nano‐ and microparticles secreted by cells and known to...

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Autores principales:	Karl T. Wagner, Milica Radisic
Formato:	article
Lenguaje:	EN
Publicado:	Wiley-VCH 2021
Materias:	cardiomyocytes exosomes extracellular vesicles heart myocardium regeneration Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/7c9a275171c2487d98971ea80d426150
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spelling	oai:doaj.org-article:7c9a275171c2487d98971ea80d4261502021-11-06T04:12:26ZA New Role for Extracellular Vesicles in Cardiac Tissue Engineering and Regenerative Medicine2699-930710.1002/anbr.202100047https://doaj.org/article/7c9a275171c2487d98971ea80d4261502021-11-01T00:00:00Zhttps://doi.org/10.1002/anbr.202100047https://doaj.org/toc/2699-9307Cardiovascular diseases are the leading cause of death worldwide. Discovering new therapies to treat heart disease requires improved understanding of cardiac physiology at a cellular level. Extracellular vesicles (EVs) are plasma membrane‐bound nano‐ and microparticles secreted by cells and known to play key roles in intercellular communication, often through transfer of biomolecular cargo. Advances in EV research have established techniques for EV isolation from tissue culture media or biofluids, as well as standards for quantitation and biomolecular characterization. EVs released by cardiac cells are known to be involved in regulating cardiac physiology as well as in the progression of myocardial diseases. Due to difficulty accessing the heart in vivo, advanced in vitro cardiac “tissues‐on‐a‐chip” have become a recent focus for studying EVs in the heart. These physiologically relevant models are producing new insight into the role of EVs in cardiac physiology and disease while providing a useful platform for screening novel EV‐based therapeutics for cardiac tissue regeneration post‐injury. Numerous hurdles have stalled the clinical translation of EV therapeutics for heart patients, but tissue‐on‐a‐chip models are playing an important role in bridging the translational gap, improving mechanistic understanding of EV signaling in cardiac physiology, disease, and repair.Karl T. WagnerMilica RadisicWiley-VCHarticlecardiomyocytesexosomesextracellular vesiclesheartmyocardiumregenerationBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENAdvanced NanoBiomed Research, Vol 1, Iss 11, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiomyocytes exosomes extracellular vesicles heart myocardium regeneration Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	cardiomyocytes exosomes extracellular vesicles heart myocardium regeneration Biotechnology TP248.13-248.65 Medical technology R855-855.5 Karl T. Wagner Milica Radisic A New Role for Extracellular Vesicles in Cardiac Tissue Engineering and Regenerative Medicine
description	Cardiovascular diseases are the leading cause of death worldwide. Discovering new therapies to treat heart disease requires improved understanding of cardiac physiology at a cellular level. Extracellular vesicles (EVs) are plasma membrane‐bound nano‐ and microparticles secreted by cells and known to play key roles in intercellular communication, often through transfer of biomolecular cargo. Advances in EV research have established techniques for EV isolation from tissue culture media or biofluids, as well as standards for quantitation and biomolecular characterization. EVs released by cardiac cells are known to be involved in regulating cardiac physiology as well as in the progression of myocardial diseases. Due to difficulty accessing the heart in vivo, advanced in vitro cardiac “tissues‐on‐a‐chip” have become a recent focus for studying EVs in the heart. These physiologically relevant models are producing new insight into the role of EVs in cardiac physiology and disease while providing a useful platform for screening novel EV‐based therapeutics for cardiac tissue regeneration post‐injury. Numerous hurdles have stalled the clinical translation of EV therapeutics for heart patients, but tissue‐on‐a‐chip models are playing an important role in bridging the translational gap, improving mechanistic understanding of EV signaling in cardiac physiology, disease, and repair.
format	article
author	Karl T. Wagner Milica Radisic
author_facet	Karl T. Wagner Milica Radisic
author_sort	Karl T. Wagner
title	A New Role for Extracellular Vesicles in Cardiac Tissue Engineering and Regenerative Medicine
title_short	A New Role for Extracellular Vesicles in Cardiac Tissue Engineering and Regenerative Medicine
title_full	A New Role for Extracellular Vesicles in Cardiac Tissue Engineering and Regenerative Medicine
title_fullStr	A New Role for Extracellular Vesicles in Cardiac Tissue Engineering and Regenerative Medicine
title_full_unstemmed	A New Role for Extracellular Vesicles in Cardiac Tissue Engineering and Regenerative Medicine
title_sort	new role for extracellular vesicles in cardiac tissue engineering and regenerative medicine
publisher	Wiley-VCH
publishDate	2021
url	https://doaj.org/article/7c9a275171c2487d98971ea80d426150
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A New Role for Extracellular Vesicles in Cardiac Tissue Engineering and Regenerative Medicine

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