Immunological exhaustion: How to make a disparate concept operational?
In this essay, we show that 3 distinct approaches to immunological exhaustion coexist and that they only partially overlap, generating potential misunderstandings. Exploring cases ranging from viral infections to cancer, we propose that it is crucial, for experimental and therapeutic purposes, to cl...
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Public Library of Science (PLoS)
2021
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oai:doaj.org-article:7c9f7c7ca4b0450b9b0faa8c78f88d682021-12-02T20:00:07ZImmunological exhaustion: How to make a disparate concept operational?1553-73661553-737410.1371/journal.ppat.1009892https://doaj.org/article/7c9f7c7ca4b0450b9b0faa8c78f88d682021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.ppat.1009892https://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374In this essay, we show that 3 distinct approaches to immunological exhaustion coexist and that they only partially overlap, generating potential misunderstandings. Exploring cases ranging from viral infections to cancer, we propose that it is crucial, for experimental and therapeutic purposes, to clarify these approaches and their interconnections so as to make the concept of exhaustion genuinely operational.Hannah KaminskiMaël LemoineThomas PradeuPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 17, Iss 9, p e1009892 (2021) |
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Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 |
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Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Hannah Kaminski Maël Lemoine Thomas Pradeu Immunological exhaustion: How to make a disparate concept operational? |
description |
In this essay, we show that 3 distinct approaches to immunological exhaustion coexist and that they only partially overlap, generating potential misunderstandings. Exploring cases ranging from viral infections to cancer, we propose that it is crucial, for experimental and therapeutic purposes, to clarify these approaches and their interconnections so as to make the concept of exhaustion genuinely operational. |
format |
article |
author |
Hannah Kaminski Maël Lemoine Thomas Pradeu |
author_facet |
Hannah Kaminski Maël Lemoine Thomas Pradeu |
author_sort |
Hannah Kaminski |
title |
Immunological exhaustion: How to make a disparate concept operational? |
title_short |
Immunological exhaustion: How to make a disparate concept operational? |
title_full |
Immunological exhaustion: How to make a disparate concept operational? |
title_fullStr |
Immunological exhaustion: How to make a disparate concept operational? |
title_full_unstemmed |
Immunological exhaustion: How to make a disparate concept operational? |
title_sort |
immunological exhaustion: how to make a disparate concept operational? |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doaj.org/article/7c9f7c7ca4b0450b9b0faa8c78f88d68 |
work_keys_str_mv |
AT hannahkaminski immunologicalexhaustionhowtomakeadisparateconceptoperational AT maellemoine immunologicalexhaustionhowtomakeadisparateconceptoperational AT thomaspradeu immunologicalexhaustionhowtomakeadisparateconceptoperational |
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1718375731546816512 |