Immunological exhaustion: How to make a disparate concept operational?

In this essay, we show that 3 distinct approaches to immunological exhaustion coexist and that they only partially overlap, generating potential misunderstandings. Exploring cases ranging from viral infections to cancer, we propose that it is crucial, for experimental and therapeutic purposes, to cl...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Hannah Kaminski, Maël Lemoine, Thomas Pradeu
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Acceso en línea:https://doaj.org/article/7c9f7c7ca4b0450b9b0faa8c78f88d68
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:7c9f7c7ca4b0450b9b0faa8c78f88d68
record_format dspace
spelling oai:doaj.org-article:7c9f7c7ca4b0450b9b0faa8c78f88d682021-12-02T20:00:07ZImmunological exhaustion: How to make a disparate concept operational?1553-73661553-737410.1371/journal.ppat.1009892https://doaj.org/article/7c9f7c7ca4b0450b9b0faa8c78f88d682021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.ppat.1009892https://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374In this essay, we show that 3 distinct approaches to immunological exhaustion coexist and that they only partially overlap, generating potential misunderstandings. Exploring cases ranging from viral infections to cancer, we propose that it is crucial, for experimental and therapeutic purposes, to clarify these approaches and their interconnections so as to make the concept of exhaustion genuinely operational.Hannah KaminskiMaël LemoineThomas PradeuPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 17, Iss 9, p e1009892 (2021)
institution DOAJ
collection DOAJ
language EN
topic Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
spellingShingle Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Hannah Kaminski
Maël Lemoine
Thomas Pradeu
Immunological exhaustion: How to make a disparate concept operational?
description In this essay, we show that 3 distinct approaches to immunological exhaustion coexist and that they only partially overlap, generating potential misunderstandings. Exploring cases ranging from viral infections to cancer, we propose that it is crucial, for experimental and therapeutic purposes, to clarify these approaches and their interconnections so as to make the concept of exhaustion genuinely operational.
format article
author Hannah Kaminski
Maël Lemoine
Thomas Pradeu
author_facet Hannah Kaminski
Maël Lemoine
Thomas Pradeu
author_sort Hannah Kaminski
title Immunological exhaustion: How to make a disparate concept operational?
title_short Immunological exhaustion: How to make a disparate concept operational?
title_full Immunological exhaustion: How to make a disparate concept operational?
title_fullStr Immunological exhaustion: How to make a disparate concept operational?
title_full_unstemmed Immunological exhaustion: How to make a disparate concept operational?
title_sort immunological exhaustion: how to make a disparate concept operational?
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/7c9f7c7ca4b0450b9b0faa8c78f88d68
work_keys_str_mv AT hannahkaminski immunologicalexhaustionhowtomakeadisparateconceptoperational
AT maellemoine immunologicalexhaustionhowtomakeadisparateconceptoperational
AT thomaspradeu immunologicalexhaustionhowtomakeadisparateconceptoperational
_version_ 1718375731546816512