Correlation between Preoperative Serum Levels of Calcium, Phosphate, and Intact Parathyroid Hormone and Radiological Outcomes in Spinal Interbody Fusion among End-Stage Renal Disease Patients

Spinal fusion surgery for end-stage renal disease (ESRD) patients is a clinical challenge. This study aimed to investigate whether postoperative radiological outcomes are related to preoperative serum calcium, phosphate, or intact parathyroid hormone (iPTH) levels in patients with ESRD who underwent...

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Autores principales:	Ting-Yu Shih, Yun-Che Wu, Sheng-Chieh Tseng, Kun-Hui Chen, Chien-Chou Pan, Cheng-Hung Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	end-stage renal disease transforaminal lumbar interbody fusion anterior cervical discectomy and fusion cage subsidence implants loosening adjacent segment disease Medicine R
Acceso en línea:	https://doaj.org/article/7ca7742c465b4c55a5a6351149bdb73d
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spelling	oai:doaj.org-article:7ca7742c465b4c55a5a6351149bdb73d2021-11-25T18:02:55ZCorrelation between Preoperative Serum Levels of Calcium, Phosphate, and Intact Parathyroid Hormone and Radiological Outcomes in Spinal Interbody Fusion among End-Stage Renal Disease Patients10.3390/jcm102254472077-0383https://doaj.org/article/7ca7742c465b4c55a5a6351149bdb73d2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5447https://doaj.org/toc/2077-0383Spinal fusion surgery for end-stage renal disease (ESRD) patients is a clinical challenge. This study aimed to investigate whether postoperative radiological outcomes are related to preoperative serum calcium, phosphate, or intact parathyroid hormone (iPTH) levels in patients with ESRD who underwent spinal interbody fusion surgery. This study included 62-consecutive patients with ESRD who underwent anterior cervical discectomy and fusion (ACDF) or transforaminal lumbar interbody fusion (TLIF) surgery for symptomatic spinal disorder. The most recent preoperative serum calcium, phosphate, and iPTH levels were recorded, and the postoperative radiographic outcomes were assessed. A significant correlation was found between the occurrence of cage subsidence and higher blood phosphate, calcium–phosphate product (Ca × P), and iPTH levels in the TLIF group. The occurrence of pedicle screw loosening was related to higher blood phosphate and Ca × P product in the TLIF group. However, no correlation was found between the fusion grades and the serum levels in either the TLIF or ACDF groups. These results indicated that higher preoperative serum phosphate and Ca × P product are risk factors for both cage subsidence and screw loosening in patients with ESRD who underwent TLIF surgery. Higher iPTH levels are also a possible risk factor for cage subsidence.Ting-Yu ShihYun-Che WuSheng-Chieh TsengKun-Hui ChenChien-Chou PanCheng-Hung LeeMDPI AGarticleend-stage renal diseasetransforaminal lumbar interbody fusionanterior cervical discectomy and fusioncage subsidenceimplants looseningadjacent segment diseaseMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5447, p 5447 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	end-stage renal disease transforaminal lumbar interbody fusion anterior cervical discectomy and fusion cage subsidence implants loosening adjacent segment disease Medicine R
spellingShingle	end-stage renal disease transforaminal lumbar interbody fusion anterior cervical discectomy and fusion cage subsidence implants loosening adjacent segment disease Medicine R Ting-Yu Shih Yun-Che Wu Sheng-Chieh Tseng Kun-Hui Chen Chien-Chou Pan Cheng-Hung Lee Correlation between Preoperative Serum Levels of Calcium, Phosphate, and Intact Parathyroid Hormone and Radiological Outcomes in Spinal Interbody Fusion among End-Stage Renal Disease Patients
description	Spinal fusion surgery for end-stage renal disease (ESRD) patients is a clinical challenge. This study aimed to investigate whether postoperative radiological outcomes are related to preoperative serum calcium, phosphate, or intact parathyroid hormone (iPTH) levels in patients with ESRD who underwent spinal interbody fusion surgery. This study included 62-consecutive patients with ESRD who underwent anterior cervical discectomy and fusion (ACDF) or transforaminal lumbar interbody fusion (TLIF) surgery for symptomatic spinal disorder. The most recent preoperative serum calcium, phosphate, and iPTH levels were recorded, and the postoperative radiographic outcomes were assessed. A significant correlation was found between the occurrence of cage subsidence and higher blood phosphate, calcium–phosphate product (Ca × P), and iPTH levels in the TLIF group. The occurrence of pedicle screw loosening was related to higher blood phosphate and Ca × P product in the TLIF group. However, no correlation was found between the fusion grades and the serum levels in either the TLIF or ACDF groups. These results indicated that higher preoperative serum phosphate and Ca × P product are risk factors for both cage subsidence and screw loosening in patients with ESRD who underwent TLIF surgery. Higher iPTH levels are also a possible risk factor for cage subsidence.
format	article
author	Ting-Yu Shih Yun-Che Wu Sheng-Chieh Tseng Kun-Hui Chen Chien-Chou Pan Cheng-Hung Lee
author_facet	Ting-Yu Shih Yun-Che Wu Sheng-Chieh Tseng Kun-Hui Chen Chien-Chou Pan Cheng-Hung Lee
author_sort	Ting-Yu Shih
title	Correlation between Preoperative Serum Levels of Calcium, Phosphate, and Intact Parathyroid Hormone and Radiological Outcomes in Spinal Interbody Fusion among End-Stage Renal Disease Patients
title_short	Correlation between Preoperative Serum Levels of Calcium, Phosphate, and Intact Parathyroid Hormone and Radiological Outcomes in Spinal Interbody Fusion among End-Stage Renal Disease Patients
title_full	Correlation between Preoperative Serum Levels of Calcium, Phosphate, and Intact Parathyroid Hormone and Radiological Outcomes in Spinal Interbody Fusion among End-Stage Renal Disease Patients
title_fullStr	Correlation between Preoperative Serum Levels of Calcium, Phosphate, and Intact Parathyroid Hormone and Radiological Outcomes in Spinal Interbody Fusion among End-Stage Renal Disease Patients
title_full_unstemmed	Correlation between Preoperative Serum Levels of Calcium, Phosphate, and Intact Parathyroid Hormone and Radiological Outcomes in Spinal Interbody Fusion among End-Stage Renal Disease Patients
title_sort	correlation between preoperative serum levels of calcium, phosphate, and intact parathyroid hormone and radiological outcomes in spinal interbody fusion among end-stage renal disease patients
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7ca7742c465b4c55a5a6351149bdb73d
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Correlation between Preoperative Serum Levels of Calcium, Phosphate, and Intact Parathyroid Hormone and Radiological Outcomes in Spinal Interbody Fusion among End-Stage Renal Disease Patients

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