Could Positive Feedback Enable Bacterial Pheromone Signaling To Coordinate Behaviors in Response to Heterogeneous Environmental Cues?

ABSTRACT Pheromone signaling (PS) underlies many important bacterial behaviors, yet its ecological functions remain unresolved. Because pheromone-mediated behaviors require high cell density, the term “quorum sensing” is widely used to describe and make sense of PS. However, while this term has unif...

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Autor principal:	Eric V. Stabb
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	cell-cell signaling gene regulation pheromone quorum sensing sociomicrobiology Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/7cab848a5a9c426b8190955b7dccaedd
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spelling	oai:doaj.org-article:7cab848a5a9c426b8190955b7dccaedd2021-11-15T16:00:24ZCould Positive Feedback Enable Bacterial Pheromone Signaling To Coordinate Behaviors in Response to Heterogeneous Environmental Cues?10.1128/mBio.00098-182150-7511https://doaj.org/article/7cab848a5a9c426b8190955b7dccaedd2018-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00098-18https://doaj.org/toc/2150-7511ABSTRACT Pheromone signaling (PS) underlies many important bacterial behaviors, yet its ecological functions remain unresolved. Because pheromone-mediated behaviors require high cell density, the term “quorum sensing” is widely used to describe and make sense of PS. However, while this term has unified and popularized the field, bacterial PS clearly has roles beyond census taking, and the complexities of PS circuits indicate broader functional capacities. Two common features of bacterial PS are its regulation in response to environmental conditions and positive-feedback loops. Combined, these could enable PS to coordinate quorum-dependent group behaviors in response to heterogeneous environmental cues. Particularly in PS systems where positive feedback is strong, cells that are relatively far from a stimulatory environment could be recruited to a group response. Testing this model will benefit from in situ examination of relevant environmental cues and PS outputs in cells across populations, with and without positive feedback, in heterogeneous environments.Eric V. StabbAmerican Society for Microbiologyarticlecell-cell signalinggene regulationpheromonequorum sensingsociomicrobiologyMicrobiologyQR1-502ENmBio, Vol 9, Iss 3 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	cell-cell signaling gene regulation pheromone quorum sensing sociomicrobiology Microbiology QR1-502
spellingShingle	cell-cell signaling gene regulation pheromone quorum sensing sociomicrobiology Microbiology QR1-502 Eric V. Stabb Could Positive Feedback Enable Bacterial Pheromone Signaling To Coordinate Behaviors in Response to Heterogeneous Environmental Cues?
description	ABSTRACT Pheromone signaling (PS) underlies many important bacterial behaviors, yet its ecological functions remain unresolved. Because pheromone-mediated behaviors require high cell density, the term “quorum sensing” is widely used to describe and make sense of PS. However, while this term has unified and popularized the field, bacterial PS clearly has roles beyond census taking, and the complexities of PS circuits indicate broader functional capacities. Two common features of bacterial PS are its regulation in response to environmental conditions and positive-feedback loops. Combined, these could enable PS to coordinate quorum-dependent group behaviors in response to heterogeneous environmental cues. Particularly in PS systems where positive feedback is strong, cells that are relatively far from a stimulatory environment could be recruited to a group response. Testing this model will benefit from in situ examination of relevant environmental cues and PS outputs in cells across populations, with and without positive feedback, in heterogeneous environments.
format	article
author	Eric V. Stabb
author_facet	Eric V. Stabb
author_sort	Eric V. Stabb
title	Could Positive Feedback Enable Bacterial Pheromone Signaling To Coordinate Behaviors in Response to Heterogeneous Environmental Cues?
title_short	Could Positive Feedback Enable Bacterial Pheromone Signaling To Coordinate Behaviors in Response to Heterogeneous Environmental Cues?
title_full	Could Positive Feedback Enable Bacterial Pheromone Signaling To Coordinate Behaviors in Response to Heterogeneous Environmental Cues?
title_fullStr	Could Positive Feedback Enable Bacterial Pheromone Signaling To Coordinate Behaviors in Response to Heterogeneous Environmental Cues?
title_full_unstemmed	Could Positive Feedback Enable Bacterial Pheromone Signaling To Coordinate Behaviors in Response to Heterogeneous Environmental Cues?
title_sort	could positive feedback enable bacterial pheromone signaling to coordinate behaviors in response to heterogeneous environmental cues?
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/7cab848a5a9c426b8190955b7dccaedd
work_keys_str_mv	AT ericvstabb couldpositivefeedbackenablebacterialpheromonesignalingtocoordinatebehaviorsinresponsetoheterogeneousenvironmentalcues
_version_	1718426976754073600

Could Positive Feedback Enable Bacterial Pheromone Signaling To Coordinate Behaviors in Response to Heterogeneous Environmental Cues?

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