Human papillomavirus infection in HIV-1 infected women in Catalonia (Spain): implications for prevention of cervical cancer.

<h4>Background</h4>High-risk human Papillomavirus infection is a necessary factor for cervical squamous intraepithelial lesions and invasive cervical cancer. In HIV-1-infected women, HPV infection is more prevalent and a higher risk of cervical cancer has been identified. We aimed to cal...

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Autores principales: Valeria Stuardo, Cristina Agustí, José Manuel Godinez, Alexandra Montoliu, Aureli Torné, Antoni Tarrats, Carmen Alcalde, Dolores Martín, Eulalia Fernández-Montoli, Cristina Vanrell, Josefa Solé, Yolanda Canet, José Manuel Marqueta, Jadiyettu Mohamed, Isabel Cuenca, Montserrat Lonca, Guillem Sirera, Elena Ferrer, Pere Domingo, Belen Lloveras, Josep María Miro, Silvia De Sanjosé, Jordi Casabona
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spelling oai:doaj.org-article:7cac2400e5de45df8966cd0e5cfd20742021-11-18T08:10:40ZHuman papillomavirus infection in HIV-1 infected women in Catalonia (Spain): implications for prevention of cervical cancer.1932-620310.1371/journal.pone.0047755https://doaj.org/article/7cac2400e5de45df8966cd0e5cfd20742012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23118894/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>High-risk human Papillomavirus infection is a necessary factor for cervical squamous intraepithelial lesions and invasive cervical cancer. In HIV-1-infected women, HPV infection is more prevalent and a higher risk of cervical cancer has been identified. We aimed to calculate the prevalence of infection by HR-HPV, determine the factors associated with this infection and abnormal cytology findings and to describe the history of cervical cancer screening in HIV-1-infected women.<h4>Methods</h4>We enrolled 479 HIV-1-infected women from the PISCIS cohort. Each patient underwent a gynecological check-up, PAP smear, HPV AND Hybrid capture, HPV genotyping, and colposcopy and biopsy, if necessary. We applied questionnaires to obtain information on sociodemographic, behavioral, clinical, and cervical screening variables. We present a cross-sectional analysis.<h4>Results</h4>Median age was 42 years. The prevalence of HR-HPV infection was 33.2% and that of high-grade squamous intraepithelial lesions (HSIL) was 3.8%. The most common genotypes were 16(23%), 53(20.3%), and 52(16.2%). The factor associated with HR-HPV infection was age <30 years (odds ratio[OR],2.5; 95%confidence interval[CI],1.1-5.6). The factors associated with the presence of HSIL or low-grade squamous intraepithelial lesions (LSIL) were CD4T-lymphocyte count <200 cells/mm(3) versus >500 cells/mm(3) (OR,8.4; 95%CI,3.7-19.2), HIV-1 viral load >10,000 copies/mL versus <400 copies/mL (OR,2.1; 95%CI,1.0-4.4), and use of oral contraceptives (OR,2.0; 95%CI,1.0-3.9). Sixty percent of HIV-1-infected women had had one Pap smear within the last 2 years.<h4>Conclusions</h4>The high prevalence of HPV infection and cervical lesions in the HIV-1-infected population in Catalonia, as well as the low coverage and frequency of screening in this group, means that better preventive efforts are necessary and should include vaccination against HPV, better accessibility to screening programs, training of health care professionals, and specific health education for HIV-1-infected women.Valeria StuardoCristina AgustíJosé Manuel GodinezAlexandra MontoliuAureli TornéAntoni TarratsCarmen AlcaldeDolores MartínEulalia Fernández-MontoliCristina VanrellJosefa SoléYolanda CanetJosé Manuel MarquetaJadiyettu MohamedIsabel CuencaMontserrat LoncaGuillem SireraElena FerrerPere DomingoBelen LloverasJosep María MiroSilvia De SanjoséJordi CasabonaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e47755 (2012)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Valeria Stuardo
Cristina Agustí
José Manuel Godinez
Alexandra Montoliu
Aureli Torné
Antoni Tarrats
Carmen Alcalde
Dolores Martín
Eulalia Fernández-Montoli
Cristina Vanrell
Josefa Solé
Yolanda Canet
José Manuel Marqueta
Jadiyettu Mohamed
Isabel Cuenca
Montserrat Lonca
Guillem Sirera
Elena Ferrer
Pere Domingo
Belen Lloveras
Josep María Miro
Silvia De Sanjosé
Jordi Casabona
Human papillomavirus infection in HIV-1 infected women in Catalonia (Spain): implications for prevention of cervical cancer.
description <h4>Background</h4>High-risk human Papillomavirus infection is a necessary factor for cervical squamous intraepithelial lesions and invasive cervical cancer. In HIV-1-infected women, HPV infection is more prevalent and a higher risk of cervical cancer has been identified. We aimed to calculate the prevalence of infection by HR-HPV, determine the factors associated with this infection and abnormal cytology findings and to describe the history of cervical cancer screening in HIV-1-infected women.<h4>Methods</h4>We enrolled 479 HIV-1-infected women from the PISCIS cohort. Each patient underwent a gynecological check-up, PAP smear, HPV AND Hybrid capture, HPV genotyping, and colposcopy and biopsy, if necessary. We applied questionnaires to obtain information on sociodemographic, behavioral, clinical, and cervical screening variables. We present a cross-sectional analysis.<h4>Results</h4>Median age was 42 years. The prevalence of HR-HPV infection was 33.2% and that of high-grade squamous intraepithelial lesions (HSIL) was 3.8%. The most common genotypes were 16(23%), 53(20.3%), and 52(16.2%). The factor associated with HR-HPV infection was age <30 years (odds ratio[OR],2.5; 95%confidence interval[CI],1.1-5.6). The factors associated with the presence of HSIL or low-grade squamous intraepithelial lesions (LSIL) were CD4T-lymphocyte count <200 cells/mm(3) versus >500 cells/mm(3) (OR,8.4; 95%CI,3.7-19.2), HIV-1 viral load >10,000 copies/mL versus <400 copies/mL (OR,2.1; 95%CI,1.0-4.4), and use of oral contraceptives (OR,2.0; 95%CI,1.0-3.9). Sixty percent of HIV-1-infected women had had one Pap smear within the last 2 years.<h4>Conclusions</h4>The high prevalence of HPV infection and cervical lesions in the HIV-1-infected population in Catalonia, as well as the low coverage and frequency of screening in this group, means that better preventive efforts are necessary and should include vaccination against HPV, better accessibility to screening programs, training of health care professionals, and specific health education for HIV-1-infected women.
format article
author Valeria Stuardo
Cristina Agustí
José Manuel Godinez
Alexandra Montoliu
Aureli Torné
Antoni Tarrats
Carmen Alcalde
Dolores Martín
Eulalia Fernández-Montoli
Cristina Vanrell
Josefa Solé
Yolanda Canet
José Manuel Marqueta
Jadiyettu Mohamed
Isabel Cuenca
Montserrat Lonca
Guillem Sirera
Elena Ferrer
Pere Domingo
Belen Lloveras
Josep María Miro
Silvia De Sanjosé
Jordi Casabona
author_facet Valeria Stuardo
Cristina Agustí
José Manuel Godinez
Alexandra Montoliu
Aureli Torné
Antoni Tarrats
Carmen Alcalde
Dolores Martín
Eulalia Fernández-Montoli
Cristina Vanrell
Josefa Solé
Yolanda Canet
José Manuel Marqueta
Jadiyettu Mohamed
Isabel Cuenca
Montserrat Lonca
Guillem Sirera
Elena Ferrer
Pere Domingo
Belen Lloveras
Josep María Miro
Silvia De Sanjosé
Jordi Casabona
author_sort Valeria Stuardo
title Human papillomavirus infection in HIV-1 infected women in Catalonia (Spain): implications for prevention of cervical cancer.
title_short Human papillomavirus infection in HIV-1 infected women in Catalonia (Spain): implications for prevention of cervical cancer.
title_full Human papillomavirus infection in HIV-1 infected women in Catalonia (Spain): implications for prevention of cervical cancer.
title_fullStr Human papillomavirus infection in HIV-1 infected women in Catalonia (Spain): implications for prevention of cervical cancer.
title_full_unstemmed Human papillomavirus infection in HIV-1 infected women in Catalonia (Spain): implications for prevention of cervical cancer.
title_sort human papillomavirus infection in hiv-1 infected women in catalonia (spain): implications for prevention of cervical cancer.
publisher Public Library of Science (PLoS)
publishDate 2012
url https://doaj.org/article/7cac2400e5de45df8966cd0e5cfd2074
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