Notch2 signaling sensitizes endothelial cells to apoptosis by negatively regulating the key protective molecule survivin.

Notch2 signaling sensitizes endothelial cells to apoptosis by negatively regulating the key protective molecule survivin.

<h4>Background</h4>Notch signaling pathway controls key functions in vascular and endothelial cells (ECs) where Notch4 plays a major role. However, little is known about the contribution of other Notch receptors. This study investigated regulation of Notch2 and further examined its impli...

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Autores principales: Thibaut Quillard, Julie Devalliere, Mathias Chatelais, Flora Coulon, Céline Séveno, Mathilde Romagnoli, Sophie Barillé Nion, Béatrice Charreau
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2009
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/7caf26718e3240c4830bb410734886a2
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