MicroRNA-494-3p inhibits formation of fast oxidative muscle fibres by targeting E1A-binding protein p300 in human-induced pluripotent stem cells

MicroRNA-494-3p inhibits formation of fast oxidative muscle fibres by targeting E1A-binding protein p300 in human-induced pluripotent stem cells

Abstract MYOD-induced microRNA-494-3p expression inhibits fast oxidative myotube formation by downregulating myosin heavy chain 2 (MYH2) in human induced pluripotent stem cells (hiPSCs) during skeletal myogenesis. However, the molecular mechanisms regulating MYH2 expression via miR-494-3p remain unk...

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Main Authors: Hirotaka Iwasaki, Yoshinori Ichihara, Katsutaro Morino, Mengistu Lemecha, Lucia Sugawara, Tatsuya Sawano, Junichiro Miake, Hidetoshi Sakurai, Eiichiro Nishi, Hiroshi Maegawa, Takeshi Imamura
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/7cb0a6e101154a0c8d896d9b8c7d988a
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https://doaj.org/article/7cb0a6e101154a0c8d896d9b8c7d988a

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