Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity

Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity

Topoisomerase 3β (Top3β) solves topological stress in DNA or RNA metabolism and its mutations are linked to mental disorders. Here, the authors describe transcriptional and behavioural impairments in Top3β-knockout mice and show that these are linked to impaired neurogenesis and synaptic plasticity....

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Autores principales: Yuyoung Joo, Yutong Xue, Yue Wang, Ross A. McDevitt, Nirnath Sah, Simone Bossi, Shuaikun Su, Seung Kyu Lee, Wei Peng, Aoji Xie, Yongqing Zhang, Yi Ding, Wai Lim Ku, Soumita Ghosh, Kenneth Fishbein, Weiping Shen, Richard Spencer, Kevin Becker, Keji Zhao, Mark P. Mattson, Henriette van Praag, Alexei Sharov, Weidong Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/7cb0bb542b2744c4b8d875684f28b8e9
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spelling oai:doaj.org-article:7cb0bb542b2744c4b8d875684f28b8e92021-12-02T17:40:05ZTopoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity10.1038/s41467-020-16884-42041-1723https://doaj.org/article/7cb0bb542b2744c4b8d875684f28b8e92020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16884-4https://doaj.org/toc/2041-1723Topoisomerase 3β (Top3β) solves topological stress in DNA or RNA metabolism and its mutations are linked to mental disorders. Here, the authors describe transcriptional and behavioural impairments in Top3β-knockout mice and show that these are linked to impaired neurogenesis and synaptic plasticity.Yuyoung JooYutong XueYue WangRoss A. McDevittNirnath SahSimone BossiShuaikun SuSeung Kyu LeeWei PengAoji XieYongqing ZhangYi DingWai Lim KuSoumita GhoshKenneth FishbeinWeiping ShenRichard SpencerKevin BeckerKeji ZhaoMark P. MattsonHenriette van PraagAlexei SharovWeidong WangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yuyoung Joo
Yutong Xue
Yue Wang
Ross A. McDevitt
Nirnath Sah
Simone Bossi
Shuaikun Su
Seung Kyu Lee
Wei Peng
Aoji Xie
Yongqing Zhang
Yi Ding
Wai Lim Ku
Soumita Ghosh
Kenneth Fishbein
Weiping Shen
Richard Spencer
Kevin Becker
Keji Zhao
Mark P. Mattson
Henriette van Praag
Alexei Sharov
Weidong Wang
Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity
description Topoisomerase 3β (Top3β) solves topological stress in DNA or RNA metabolism and its mutations are linked to mental disorders. Here, the authors describe transcriptional and behavioural impairments in Top3β-knockout mice and show that these are linked to impaired neurogenesis and synaptic plasticity.
format article
author Yuyoung Joo
Yutong Xue
Yue Wang
Ross A. McDevitt
Nirnath Sah
Simone Bossi
Shuaikun Su
Seung Kyu Lee
Wei Peng
Aoji Xie
Yongqing Zhang
Yi Ding
Wai Lim Ku
Soumita Ghosh
Kenneth Fishbein
Weiping Shen
Richard Spencer
Kevin Becker
Keji Zhao
Mark P. Mattson
Henriette van Praag
Alexei Sharov
Weidong Wang
author_facet Yuyoung Joo
Yutong Xue
Yue Wang
Ross A. McDevitt
Nirnath Sah
Simone Bossi
Shuaikun Su
Seung Kyu Lee
Wei Peng
Aoji Xie
Yongqing Zhang
Yi Ding
Wai Lim Ku
Soumita Ghosh
Kenneth Fishbein
Weiping Shen
Richard Spencer
Kevin Becker
Keji Zhao
Mark P. Mattson
Henriette van Praag
Alexei Sharov
Weidong Wang
author_sort Yuyoung Joo
title Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity
title_short Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity
title_full Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity
title_fullStr Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity
title_full_unstemmed Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity
title_sort topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/7cb0bb542b2744c4b8d875684f28b8e9
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