Imaging features of histological subtypes of hepatocellular carcinoma: Implication for LI-RADS

Background & Aims: The histopathological subtypes of hepatocellular carcinoma (HCC) are associated with distinct clinical features and prognoses. This study aims to report Liver Imaging Reporting and Data System (LI-RADS)-defined imaging features of different HCC subtypes in a cohort of rese...

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Autores principales:	Roberto Cannella, Marco Dioguardi Burgio, Aurélie Beaufrère, Loïc Trapani, Valérie Paradis, Christian Hobeika, Francois Cauchy, Mohamed Bouattour, Valérie Vilgrain, Riccardo Sartoris, Maxime Ronot
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Hepatocellular carcinoma LI-RADS Histopathological subtypes Computed tomography Magnetic resonance imaging Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/7cb312b9a0884cd8b09f37225a9fa1d8
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spelling	oai:doaj.org-article:7cb312b9a0884cd8b09f37225a9fa1d82021-11-20T05:12:02ZImaging features of histological subtypes of hepatocellular carcinoma: Implication for LI-RADS2589-555910.1016/j.jhepr.2021.100380https://doaj.org/article/7cb312b9a0884cd8b09f37225a9fa1d82021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589555921001567https://doaj.org/toc/2589-5559Background & Aims: The histopathological subtypes of hepatocellular carcinoma (HCC) are associated with distinct clinical features and prognoses. This study aims to report Liver Imaging Reporting and Data System (LI-RADS)-defined imaging features of different HCC subtypes in a cohort of resected tumours and to assess the influence of HCC subtypes on computed tomography (CT)/magnetic resonance imaging (MRI) LI-RADS categorisation in the subgroup of high-risk patients. Methods: This retrospective institutional review board-approved study included patients with resected HCCs and available histopathological classification. Three radiologists independently reviewed preoperative CT and MRI exams. The readers evaluated the presence of imaging features according to LI-RADS v2018 definitions and provided a LI-RADS category in patients at high risk of HCC. Differences in LI-RADS features and categorisations were assessed for not otherwise specified (NOS-HCC), steatohepatitic (SH-HCC), and macrotrabecular-massive (MTM-HCC) types of HCCs. Results: Two hundred and seventy-seven patients (median age 64.0 years, 215 [77.6%] men) were analysed, which involved 295 HCCs. There were 197 (66.7%) NOS-HCCs, 62 (21.0%) SH-HCCs, 23 (7.8%) MTM-HCCs, and 13 (4.5%) other rare subtypes. The following features were more frequent in MTM-HCC: elevated α-foetoprotein serum levels (p <0.001), tumour-in-vein (p <0.001 on CT, p ≤0.052 on MRI), presence of at least 1 LR-M feature (p ≤0.010 on CT), infiltrative appearance (p ≤0.032 on CT), necrosis or severe ischaemia (p ≤0.038 on CT), and larger size (p ≤0.006 on CT, p ≤0.011 on MRI). SH-HCC was associated with fat in mass (p <0.001 on CT, p ≤0.002 on MRI). The distribution of the LI-RADS major features and categories in high-risk patients did not significantly differ among the 3 main HCC subtypes. Conclusions: The distribution of LI-RADS major features and categories is not different among the HCC subtypes. Nevertheless, careful analysis of tumour-in-vein, LR-M, and ancillary features as well as clinico-biological data can provide information for the non-invasive diagnosis of HCC subtypes. Lay summary: In high-risk patients, the overall distribution of LI-RADS major features and categories is not different among the histological subtypes of hepatocellular carcinoma, but tumour-in-vein, presence of LR-M features, and ancillary features can provide information for the non-invasive diagnosis of hepatocellular carcinoma subtypes.Roberto CannellaMarco Dioguardi BurgioAurélie BeaufrèreLoïc TrapaniValérie ParadisChristian HobeikaFrancois CauchyMohamed BouattourValérie VilgrainRiccardo SartorisMaxime RonotElsevierarticleHepatocellular carcinomaLI-RADSHistopathological subtypesComputed tomographyMagnetic resonance imagingDiseases of the digestive system. GastroenterologyRC799-869ENJHEP Reports, Vol 3, Iss 6, Pp 100380- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hepatocellular carcinoma LI-RADS Histopathological subtypes Computed tomography Magnetic resonance imaging Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Hepatocellular carcinoma LI-RADS Histopathological subtypes Computed tomography Magnetic resonance imaging Diseases of the digestive system. Gastroenterology RC799-869 Roberto Cannella Marco Dioguardi Burgio Aurélie Beaufrère Loïc Trapani Valérie Paradis Christian Hobeika Francois Cauchy Mohamed Bouattour Valérie Vilgrain Riccardo Sartoris Maxime Ronot Imaging features of histological subtypes of hepatocellular carcinoma: Implication for LI-RADS
description	Background & Aims: The histopathological subtypes of hepatocellular carcinoma (HCC) are associated with distinct clinical features and prognoses. This study aims to report Liver Imaging Reporting and Data System (LI-RADS)-defined imaging features of different HCC subtypes in a cohort of resected tumours and to assess the influence of HCC subtypes on computed tomography (CT)/magnetic resonance imaging (MRI) LI-RADS categorisation in the subgroup of high-risk patients. Methods: This retrospective institutional review board-approved study included patients with resected HCCs and available histopathological classification. Three radiologists independently reviewed preoperative CT and MRI exams. The readers evaluated the presence of imaging features according to LI-RADS v2018 definitions and provided a LI-RADS category in patients at high risk of HCC. Differences in LI-RADS features and categorisations were assessed for not otherwise specified (NOS-HCC), steatohepatitic (SH-HCC), and macrotrabecular-massive (MTM-HCC) types of HCCs. Results: Two hundred and seventy-seven patients (median age 64.0 years, 215 [77.6%] men) were analysed, which involved 295 HCCs. There were 197 (66.7%) NOS-HCCs, 62 (21.0%) SH-HCCs, 23 (7.8%) MTM-HCCs, and 13 (4.5%) other rare subtypes. The following features were more frequent in MTM-HCC: elevated α-foetoprotein serum levels (p <0.001), tumour-in-vein (p <0.001 on CT, p ≤0.052 on MRI), presence of at least 1 LR-M feature (p ≤0.010 on CT), infiltrative appearance (p ≤0.032 on CT), necrosis or severe ischaemia (p ≤0.038 on CT), and larger size (p ≤0.006 on CT, p ≤0.011 on MRI). SH-HCC was associated with fat in mass (p <0.001 on CT, p ≤0.002 on MRI). The distribution of the LI-RADS major features and categories in high-risk patients did not significantly differ among the 3 main HCC subtypes. Conclusions: The distribution of LI-RADS major features and categories is not different among the HCC subtypes. Nevertheless, careful analysis of tumour-in-vein, LR-M, and ancillary features as well as clinico-biological data can provide information for the non-invasive diagnosis of HCC subtypes. Lay summary: In high-risk patients, the overall distribution of LI-RADS major features and categories is not different among the histological subtypes of hepatocellular carcinoma, but tumour-in-vein, presence of LR-M features, and ancillary features can provide information for the non-invasive diagnosis of hepatocellular carcinoma subtypes.
format	article
author	Roberto Cannella Marco Dioguardi Burgio Aurélie Beaufrère Loïc Trapani Valérie Paradis Christian Hobeika Francois Cauchy Mohamed Bouattour Valérie Vilgrain Riccardo Sartoris Maxime Ronot
author_facet	Roberto Cannella Marco Dioguardi Burgio Aurélie Beaufrère Loïc Trapani Valérie Paradis Christian Hobeika Francois Cauchy Mohamed Bouattour Valérie Vilgrain Riccardo Sartoris Maxime Ronot
author_sort	Roberto Cannella
title	Imaging features of histological subtypes of hepatocellular carcinoma: Implication for LI-RADS
title_short	Imaging features of histological subtypes of hepatocellular carcinoma: Implication for LI-RADS
title_full	Imaging features of histological subtypes of hepatocellular carcinoma: Implication for LI-RADS
title_fullStr	Imaging features of histological subtypes of hepatocellular carcinoma: Implication for LI-RADS
title_full_unstemmed	Imaging features of histological subtypes of hepatocellular carcinoma: Implication for LI-RADS
title_sort	imaging features of histological subtypes of hepatocellular carcinoma: implication for li-rads
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/7cb312b9a0884cd8b09f37225a9fa1d8
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Imaging features of histological subtypes of hepatocellular carcinoma: Implication for LI-RADS

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